The treatment of this disease is a worldwide problem, involving multiple disciplines, and diseases involving genetic factors, immune function factors, inflammation of internal organs and their tendon tissues, and bone tissue necrosis. progress. The main clinical manifestations are: fatigue, weight loss, long-term or intermittent low-grade fever, anorexia, mild anemia and other mild symptoms in the early stage; in addition, there are also symptoms of arthritic pain at the lesion site, muscle spasm around the joint, stiffness, and obvious morning wake up, etc. symptom.
Pathogenesis
Gene Elements
The post-transcriptional regulation of miRNAs is reflected in the specificity of bone metabolism and cell proliferation, differentiation, apoptosis and other related abnormal expressions related to miRNAs. Combined with bioinformatics technology to analyze differentially expressed miRNAs, predict their target genes, and predict intercellular signaling pathways in high-risk groups (obesity, diabetes, hyperinsulinemia, calcium and phosphorus metabolism disorders and other metabolic diseases). , it is speculated that miRNAs involved in abnormal regulation will be reflected in serum.
genetic factors
Animal experimental studies have shown that the positive rate of HLA-B27 in AS patients is as high as 90% to 96%, while the proportion of healthy people is only 4% to 9%. In the context of bacterial infection, the inflammatory response is elicited by altered intracellular signaling by HLA-B27.
Immune factors
AS patients’ serum IgA rheumatoid factor, serum C4 and IgA levels, and circulating immune complexes in serum suggest that immune mechanisms are involved in the occurrence of this disease. Various functions of peripheral blood CD4+T cells, CD8+T cells, CD4+T/CD8+ and interleukin (IL)-2 secreted by Th1 cells can promote the progressive decline of T lymphocytes and NK cells in early stage patients. Proliferation, differentiation and expression, and even antibody production, play important roles in cellular and humoral immunity.
Endocrine factors
The ratio of male to female patients with ankylosing spondylitis ranges from 10:1 to 3.5:1. Endocrine results confirm that the immune response to sex hormones and their levels and metabolites are abnormal due to the imbalance of the internal environment. To sum up, the etiology of ankylosing spondylitis is the result of the combined effects of gene elements, genetic factors, inflammatory and infectious factors, immune factors, and endocrine factors. In terms of treatment, formulating an appropriate treatment plan according to the etiological characteristics of patients has important practical significance and value in ensuring the curative effect and improving the survival and quality of life of patients. Through strict etiological treatment characteristics and selection of appropriate Chinese and Western medicine treatment methods, the treatment effect of various methods will be highlighted, and the treatment of patients with ankylosing spondylitis will play a positive role.
