There is a key indicator in the treatment of renal disease, which has a profound impact on renal function, which is proteinuria quantification. From the early stage to the middle stage of kidney disease, proteinuria can be said to run through the entire development process of kidney disease. Therefore, patients with persistently low levels of proteinuria tend to have stable renal function and better prognosis.
However, what worries many kidney friends is that proteinuria does not seem to come down as easily as expected, and sometimes it even “rebounds” after a long time. How can kidney friends break this deadlock?
Why some proteinuria is difficult to drop? To clarify these two issues first:
Differentiation of pathological types of kidney disease
There are many types of chronic kidney disease, each Different pathological types of nephropathy have different severity, proteinuria, and the degree of difficulty in naturally reducing protein.
Nephrotic syndrome patients are often accompanied by massive proteinuria, including membranous nephropathy, minimal change nephropathy, mesangial proliferative glomerulonephritis, Focal segmental glomerulosclerosis, etc. Taking membranous nephropathy as an example, in the first two stages, the disease is generally milder and the proteinuria is less. At this time, active treatment with hormones and immunosuppressive agents will generally be better controlled, and after the progression to stage 3 renal insufficiency Obviously, proteinuria generally exceeds 3.5g/24h, and it is difficult to completely turn negative for proteinuria, mainly maintenance therapy. In addition, patients with minimal change disease are more sensitive to hormones, and urine protein is easy to turn negative, but if the recurrence rate of focal segmental glomerulosclerosis is high, protein reduction is often not very optimistic.
Differentiation of kidney disease treatment stages
Simply put, even if the same pathological type of kidney disease, the stage of development Different, taking the same drug, the final treatment results are definitely different. Generally speaking, the treatment of proteinuria in the first period of various pathological types of nephropathy has better effect, the proteinuria is more stable, and the recurrence rate is lower. However, once renal insufficiency occurs and the entire internal environment is unstable, it is not so easy to completely turn negative for proteinuria.
Therefore, kidney patients should seize the opportunity of treatment, and early treatment is the key to reducing protein.
After understanding these two points, kidney patients will be much more relaxed in protein-lowering therapy. In addition, protein-reducing therapy also needs to remember these four “mantras”:
Remember a controlled diet to avoid heavier proteinuria;
< p data-track="12">The second control drug should not be forgotten, to prevent excessive treatment;
The third prevention and infection should be adhered to to reduce the recurrence rate of the disease;
< p data-track="14">Four stable complications, comprehensive kidney protection protein is more stable.
The first point to reduce protein is to adhere to the principle of a low-protein diet. On the one hand, avoid consuming too much protein and increase the burden on the kidneys, which is not conducive to the stability of the disease. On the other hand, avoid protein leakage aggravated, and then aggravated renal damage, forming a vicious circle;
The second point is protein-lowering drugs such as hormones, immunosuppressants, and other drugs such as sartans, Prily These drugs need to be taken consistently to be more effective, but we must also be careful not to over-treat, so as not to cause a decline in immunity and increase the risk of recurrence such as infection, which is not worth the loss.
The third point is to avoid infection. Patients with kidney disease have low immunity. Coupled with the use of immune preparations, infections are more likely to occur. In order to reduce the risk of recurrence, kidney friends It’s best to be prepared for infection.
The fourth point is to reduce protein and do not ignore the treatment of other symptoms. Including edema, hypertension, hematuria, anemia, etc., all of which will affect the overall condition and the quality of renal function. The so-called “involvement affects the whole body”, kidney friends should adhere to comprehensive treatment, do not focus on one or the other, and favor any indicator. .