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Remember the Brain Age Reducing Factor—Hercules PQQ Mitochondrial Supplement that I just shared with you not long ago? (Related reading: Brain Age Reducing Factor, Hercules PQQ mitochondrial supplement, revealing its 10 major benefits…)
Many people are unfamiliar with this very unusual compound.
As everyone knows, PQQ, as a member of the quinone family, can play a very large antioxidant effect.
It can significantly improve the function of mitochondria, increase the concentration of coenzyme NAD+, stimulate the production of more mitochondria, help cells resist the attack of oxygen free radicals, and protect nerve cell development , growth, and anti-aging.
and is expected to adjuvant treatment of neurodegenerative diseases.
Today, I would like to introduce another brain age reducer that is often combined with PQQ supplements – phosphatidylserine PS.< /strong>
It also has a powerful antioxidant effect, can escort human health, and is often used with PQQ supplements.
Let’s have a look together↓
Phosphatidylserine PS, what is it?
Phosphatidylserine (abbreviated as Ptd-L-Ser or PS) is a phospholipid (fat molecule attached to phosphate) that is part of cell membranes.
It plays a key role in cell cycle signaling, especially in relation to apoptosis, and is a key pathway for viruses to enter cells by apoptosis-mimicking.
Phosphatidylserine (PS) is the major acidic phospholipid, accounting for 13-15% of human cortical phospholipids, phospholipids are a A type of fat whose structure makes it both hydrophilic (attracted by water) and hydrophobic (repelled by water).
These properties allow phospholipids to be neatly arranged in two parallel layers, called a phospholipid bilayer.
Half of the body’s total phosphatidylserine, PS, is found in the brain.
As a result, many people will be deficient in phosphatidylserine, and people of all ages can benefit from PS supplementation.
Phosphatidylserine is particularly important for brain function and is key to normal brain function, and people with Parkinson’s disease often have low levels of phosphatidylserine.
(Above: Changes in brain activity after 3 weeks of PS intake ↑)
Generally used as a supplement to improve human brain cognitive function and memory, stress relief, and more;
In mammals, phosphatidylserine is produced by phosphatidylethanolamine or phosphatidylcholine via two Ca2+-dependent head group exchange reactions in the endoplasmic reticulum Derived from one, phosphatidylserine can also produce phosphatidylethanolamine and phosphatidylcholine.
So, what are the benefits of phosphatidylserine? ↓
7 benefits of phosphatidylserine PS
→Improves cognitive function
Phosphatidylserine is the only FDA-approved brain supplement to treat age-related cognitive decline and Alzheimer’s disease.
Our neurons need phosphatidylserine to conduct nerve impulses.
PS is essential for maintaining neuroplasticity, the brain’s ability to repair existing brain cells and create new ones.
(above: the importance of PS to brain cells↑)
Phosphatidylserine increases brain cell fluidity, allowing cells to adapt and respond effectively to stressors.
In a clinical trial of 18 young adults, researchers found that a supplement containing 400 mg of phosphatidylserine (PS) increased subjects’ ability to perform mathematical calculations speed and reduce errors.
Additionally, in three clinical trials protecting 263 participants (36 children with ADHD and 227 older adults), supplementation with 200-300 mg of PS/day improves subject memory.
→Reduces symptoms of neurodegenerative diseases
Young and old alike, it can be used safely to enhance memory.
It is also a favorite supplement used by students abroad to enhance memory, concentration and test scores.
PS levels naturally decline with age, and it can lead to improved memory, even in Alzheimer’s patients.
(above: ps sleeps better, has less anxiety, and is more focused ↑)
Phosphatidylserine prevents age-related mental decline and holds promise for Alzheimer’s disease, dementia, and the accompanying depression.
Research has found that phosphatidylserine (PS) can prevent the accumulation of beta amyloid in the brain, helping to prevent or slow the progression of Alzheimer’s disease.
Phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) modulate the immune function of phagocytes, PS/PC liposomes Pretreatment of cytoplasmic cells significantly inhibits Abeta/IFN-γ-induced TNF-α, NO and *O(2)-production; has neuroprotective and antioxidant properties by inhibiting microglial activation, thereby Supports the anti-dementia effect of PS.
→Improve well-being and boost the release of neurotransmitters in the brain
Neurotransmitters are chemicals brain cells use to communicate with each other and help improve the body’s ability to be happy, sleep, relax and deal with stress.
Most people have very low levels of these chemicals in the brain.
Phosphatidylserine PS promotes the release of these 4 major neurotransmittersserotonin, norepinephrine, dopamine and acetylcholine, thereby accelerating strong>Communication between brain cells.
→Reduces cortisol levels, reduces stress, improves depression
Excessive cortisol levels increase the risk of diabetes, obesity, heart disease, immune system suppression and digestive disorders.
Research has found that phosphatidylserine may reduce the effects of physical and mental stress by lowering cortisol levels.
Also, studies have found that phosphatidylserine PS not only lowers cortisol, but also improves physical performance, speeds recovery, and reduces post-exercise muscle soreness.
PS reduces the secretion of corticotropin (corticotropin is a hormone that triggers cortisol) and improves athletic performance.
Phosphatidylserine also helps reduce depression, especially in people over the age of 65.
Theoretically, this phospholipid helps the brain regulate mood, as phosphatidylserine levels tend to decline with age.
→Reduce ADHD symptoms
Attention deficit hyperactivity disorder (ADHD) is a mental disorder characterized by impulsivity, inattention, and hyperactivity.
Phosphatidylserine PS, may be a safe and effective natural alternative for ADHD treatment.
Phosphatidylserine PSalone or in combination with omega-3 fatty acids reduces ADHD symptoms in two clinical trials of 236 children.
Children who switched from placebo to PS-Omega3 had significantly lower CRS-P and CRS-T subscale scores compared to baseline scores, and treatment was well tolerated .
Another controlled study found that PS significantly improved ADHD symptoms and short-term auditory memory in children. PS is a safe and natural nutritional strategy to improve mental performance in young children with ADHD.
So, a child with ADHD, PS+DHA fish oil, will help him a lot.
→enhances brain function and synergizes with other supplements
Phosphatidylserine, which is effectively absorbed in the human body, crosses the blood-brain barrier and safely slows, stops or reverses biochemical changes and structural deterioration of nerve cells.
It enhances brain functions including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to concentrate and Concentration, reasoning and problem-solving skills, language skills and communication skills, it also supports motor function.
Can also work with some other brain supplements to improve brain function, such as the mitochondrial enhancer PQQ we covered last time.
There’s also curcumin, another great brain booster that increases blood flow to the brain, reduces inflammation, and boosts the production of the neurotransmitters serotonin and dopamine.
Curcumin helps protect the brain, slow aging, and break down the brain plaques associated with Alzheimer’s disease.
The curcumin is easily malabsorbed, up to 85% will not be absorbed when it passes through the intestinal tract, and needs to be combined with black pepper.
Studies have found that one way to increase the bioavailability of curcumin is with phosphatidylserine.
Studies found that curcumin-loaded nanostructured lipid carriers significantly inhibited lipid accumulation and promotion in cultured macrophages compared to curcumin or phosphatidylserine alone inflammatory cytokine production, and significantly promote the release of anti-inflammatory cytokines.
curcumin-loaded nanostructured lipid carriers significantly inhibited lipid accumulation and pro-inflammatory factor production in cultured macrophages, and evidently promoted release of anti-inflammatory cytokines, when compared with curcumin or phosphatidylserine alone.
p>
So, what are the sources of this phosphatidylserine supplement?
Then look down↓
Main source of phosphatidylserine
The average modern human diet now contains one-third the amount of phosphatidylserine in the diet 100 years ago.
Phosphatidylserine, on the other hand, is mainly found in many animal foods, including, for example, beef brain, Atlantic mackerel, chicken heart, eel and offal, etc. .
Phosphatidylserine is found in many foods, but mostly in animal foods that few of us eat — top sources are cow brains, Atlantic mackerel, chicken hearts, eel, and offal.
Above: Foods with high PS content perfect keto↑
Tuna, chicken thighs, and white beans contain 194 mg, 134 mg, and 107 mg of phosphatidylserine per 3.5 ounces, respectively.
→Supplemental dosage of phosphatidylserine
Phosphatidylserine has no corresponding RDA (recommended dietary intake) and no optimal dosage for specific conditions.
The standard intake is 100mg. You can eat so much at the beginning to find your feelings. The general recommended dose for patients with memory impairment is 200-300mg or more per day;< /p>
For
children and adolescents, the recommended dosage does not exceed 200 mg per day.
→Side Effects of Phosphatidylserine Supplements
The most common side effects of phosphatidylserine supplements are indigestion and insomnia, especially when the daily dose is more than 300 mg.
Phosphatidylserine should be avoided if taking blood thinners or anti-inflammatory drugs.
Also, phosphatidylserine cannot be taken with certain anticholinergic drugs (such as antihistamines and antidepressants) and may reduce the effectiveness.
Since phosphatidylserine also increases acetylcholine levels, it may alter the effectiveness of these drugs and magnify side effects.
Finally, pregnant or breastfeeding women should try to avoid phosphatidylserine supplements.
Key Thin Dragon Says
Modern people, we are all overusing our brains, causing our brains to be very active all the time, which is the main reason for tension, anxiety, and poor sleep.
Long-term, the brain degenerates very seriously, causing serious problems. If you want to calm down, we need some nutritional help. PQQ and PS are both called brain degeneration. age.
If you find yourself losing concentration, memory loss, nervousness, anxiety, insomnia, try supplementing them.
Phosphatidylserine is a component of healthy brain cell membranes and can normalize levels of important neurotransmitters and stress hormones.
is one of the few brain supplements that is beneficial for older adults and children.
It is also the only FDA-approved brain supplement for the treatment of age-related cognitive decline and Alzheimer’s disease.
Use in conjunction with other antioxidants, such as PQQ, curcumin, resveratrol, fish oil supplements, etc., phosphatidylserine will have a better effect on the brain.