People take food as their priority, and food directly affects human health. Good and reasonable healthy eating habits are an important aspect of health care, which enables the body to grow and develop healthily. Unhealthy eating habits can lead to the disorder of normal physiological functions of the human body and the infection of diseases.
In recent years, fasting has become a new favorite in the scientific community, including time-restricted fasting, calorie-restricted diets, and more. Fasting has been shown to lose weight and prolong life in animals, in fact, a growing body of research shows that fasting has many health benefits, improving metabolic health, preventing or delaying diseases that come with ageing, and even slowing tumor growth .
On October 20, 2022, researchers from Northwestern University published an article online in the top international journal “Science” Research paper titled “Time-restricted feeding mitigates obesity through adipocyte thermogenesis.”
This study shows that eating when you should and fasting when you shouldn’t make it difficult to eat fat, consistent with a circadian rhythm, night-fed mice, through fat Cellular thermogenesis consumes more calories, thereby protecting them from diet-induced obesity. The findings help explain the mechanisms behind the benefits of time-restricted eating and how circadian rhythm disturbances can lead to metabolic diseases.
In the study, researchers divided mice into three groups and exposed them to a daytime, nighttime, and all-day high-fat diet (HFD) and found that compared with nighttime mice, exposure to Daytime and all-day mice gained more body weight and consumed less oxygen. This suggests that feeding the mice during periods of inactivity leads to weight gain, in part due to reduced energy expenditure.
Due to increased energy expenditure in mice fed at night, researchers analyzed whether adipose tissue metabolism might vary with the timing of feeding and found that nocturnal-fed mice had glycogenase in adipose tissue More metabolites and more fat cells produce more heat.
The researchers analyzed whether feeding at different times affected the circadian clock in fat, and found that only mice fed at night had the highest expressed circadian clock, while Day-fed mice had a reduced magnitude of circadian clock expression in fat, which would directly affect adipocyte thermogenesis rhythms, which reduced body weight gain during nighttime feeding.
Mice lost more weight only if they ate at night
In order to understand the metabolic mechanism of adipocyte thermogenesis, the researchers performed bioenergetics and metabolomic analysis of adipocytes,found that creatine plays a key role in the process of adipocyte thermogenesis. A metabolite was significantly increased. Creatine can rapidly synthesize ATP, accelerate energy turnover, and provide energy for the body quickly.
Further, the researchers demonstrated that decreased expression of the adipocyte circadian clock drives metabolic defects in mice by disrupting rhythmic creatine metabolism.
The role of creatine in fat thermogenesis