Introduction: In real life, many people can’t tell the difference between antibiotics and anti-inflammatory drugs, and often take antibiotics under the banner of anti-inflammation without knowing it.
In fact, the fundamental reason for confusing antibiotics and anti-inflammatory drugs is that people confuse “infection” and “inflammation”. “inflamed”.
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First of all, what are anti-inflammatory drugs?
The so-called anti-inflammatory drugs, as the name suggests, can be used to eliminate inflammation, so what is As for inflammation, any of our human diseases, including infectious diseases, can show symptoms such as redness, swelling, heat, and pain.
Anti-inflammatory drugs are drugs that can eliminate the above symptoms. Why do ordinary people often use anti-inflammatory drugs as antibiotics? ? That’s because when an infectious disease occurs in the body, pathogenic microorganisms invade the body and release a large amount of inflammatory mediators, which will produce a series of inflammation-like media.
The anti-inflammatory drugs in our medical field are actually non-steroidal anti-inflammatory drugs, such as aspirin, Acetaminophen, and some glucocorticoids, like dexamethasone, prednisone.
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What is the difference between anti-inflammatory drugs and antibiotics?
1. Difference in efficacy:
Antibiotic drugs are usually in very low concentrations, which are good for all the living bacteria in our body, but also have disadvantages, blood stasis in daily life , broken skin, allergies, dermatitis and other skin diseases can be treated with anti-inflammatory drugs, which is the difference between anti-inflammatory drugs and antibiotics.
2. The difference between symptoms:
Usually speaking, anti-inflammatory drugs are used to eliminate inflammation. Usually, patients with inflammation can be treated with anti-inflammatory drugs. For example, aspirin can relieve the surface inflammation of patients and prevent Inflammation aggravates the patient’s own condition, eliminates the patient’s inflammation, and effectively prevents the reproduction of bacteria caused by inflammation.
Antibiotics can kill all bacteria, cells in the body, treat bacteria, viruses, parasites in patients, This even includes antineoplastic tablets, which are antibiotic drugs.
3. Functional differences:
Antibiotics are used to treat inflammatory diseases caused by bacteria and microorganisms. Antibiotics can kill these microorganisms and can only kill pathogenic bacteria. It cannot be used clinically to prevent infection.
If antibiotics are used too much, patients will develop drug resistance, which will not occur the next time they are used No effect, and anti-inflammatory drugs are used for anti-inflammatory, which can eliminate the hidden dangers of patients with inflammation.
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Is amoxicillin an anti-inflammatory drug?
AMoxicillin is an oral semi-synthetic penicillin and is an antibiotic drug with a broad antibacterial spectrum.
It belongs to β-lactam antibiotics, with strong ability to penetrate cell walls, strong bactericidal effect, and A variety of pathogenic gram, gram-positive bacteria and gram-negative bacteria have strong antibacterial and bactericidal effects.
Amoxicillin can be used in the treatment of various inflammatory conditions caused by susceptible bacteria, including hemolytic streptococci, Upper respiratory tract infection caused by Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus.
Urogenital infections caused by Proteus Escherichia coli Enterococcus faecalis and by various susceptible bacteria Skin and soft tissue infections, lower respiratory tract infections simple gonorrhea and typhoid fever.
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Advice: There are only 2 real anti-inflammatory drugs, don’t abuse
- One of the anti-inflammatory drugs – non-steroidal anti-inflammatory drugs
There are a variety of non-steroidal anti-inflammatory drugs clinically, which can generally be divided into selective cyclooxygenation Enzyme-2 inhibitors (COX-2) and non-selective COX-2 inhibitors, selective cyclooxygenase-2 inhibitors such as meloxicam, nimesulide, etc., ibuprofen, diclofenac sodium, etc. Nonselective COX-2 inhibitors.
Non-steroidal anti-inflammatory drugs mainly inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase To a positive effect, after combining with cyclooxygenase, the non-steroidal anti-inflammatory drug covers the active center of the enzyme, thereby blocking the arachidonic acid, which is converted into prostaglandin by epoxy and enzyme to play an anti-inflammatory effect.
But everyone should understand that the incidence of adverse reactions of non-steroidal anti-inflammatory drugs is relatively high. The clinical application of anti-inflammatory drugs is also subject to corresponding restrictions. While the carrier anti-inflammatory drugs play a role, it is also easy to induce digestive system damage, kidney damage and a series of other adverse reactions.
Gastrointestinal adverse reactions mainly include peptic ulcer, dyspepsia, gastrointestinal bleeding, mainly due to Non-steroidal anti-inflammatory drugs can inhibit the synthesis of prostaglandins and damage the mucosal barrier of the gastrointestinal tract.
The damage to the kidney is mainly manifested in glomerular filtration or function and renal perfusion, although prostaglandins are not involved, Basic renal function is maintained, but when blood volume decreases, prostaglandins can maintain renal perfusion and glomerular filtration through vasodilation.
Non-steroidal anti-inflammatory drugs increase the risk of stroke, which is related to their ability to aggregate platelets, which can lead to Increased risk of venous thrombosis.
It is recommended that people should start from a small dose when taking the drug and increase the dose, and should pay attention to adverse reactions such as upper abdominal discomfort, It is best to choose enteric-coated tablets and sustained-release pharmaceutical preparations.
On the other hand, we should pay attention to the combination of drugs, and be cautious about unreasonable combination of drugs.
- Steroidal anti-inflammatory drugs – glucocorticoids and their derivatives
Another anti-inflammatory drug is the glucocorticoid and its derivatives secreted by the adrenal cortex we mentioned. Glucocorticoid can prevent lymphocytes, granulocytes, macrophages and other inflammatory cells from moving to the inflammatory site Response to inflammatory mediators such as kinins, histamines, and slow-reacting substances.
Steroid anti-inflammatory drugs can reduce the degree of capillary congestion and permeability and cause the decline of phagocyte function, ensuring Lysosomal membrane stability.
Steroidal anti-inflammatory drugs can interfere with the complement involved in the inflammatory response and prevent the repair of tissue damage after inflammation, Therefore, glucocorticoids can effectively relieve tissue adhesion and scar formation in the late stage of inflammation.
For example, budesonide can effectively improve the smooth muscle cell lysosomal membrane and endothelial cells after body absorption stability, and reduce the release of allergic active mediators and cytokines, thereby reducing smooth muscle contraction, while reducing the impact of cytokines on inflammatory cells, thereby producing a strong anti-inflammatory effect.
But everyone must understand that long-term use of glucocorticoids will reduce their immunity.It is easy to cause water and electrolyte disorders, which will not only lead to edema and hypokalemia caused by water and sodium retention, but also accelerate protein dissimilation and calcium ion excretion, resulting in muscle atrophy, weakness, and osteoporosis.
In addition, glucocorticoids can promote protein breakdown, inhibit protein synthesis and delay the formation of granulation tissue , and lead to slow wound healing.
After taking glucocorticoids, the drug cannot be stopped suddenly, and there will be withdrawal reactions, mainly manifested as depression and anorexia , low fever, low blood pressure, low blood sugar and other symptoms.