Does drinking water affect the efficacy of medicine? Drink more or less water, the effect of medicine is very different

Text/Yangcheng Evening News All Media Reporter Xue Renzheng Correspondent Wang Wenyu

Many people take their medication with a glass of water. In fact, some medicines have requirements on the amount and temperature of water. Some medicines should drink more water when taking them, while others should drink as little or no water as possible, and some medicines cannot be taken with hot water. So when taking medicine, how to drink water can not only be beneficial to health, but also protect the efficacy of the medicine? The pharmacist, deputy director of the Department of Pharmacy, Guangzhou Medical University Affiliated Hospital of Traditional Chinese Medicine, answered.

Take your medication with normal water

Normal tablet: drink 150ml of water when taking the medicine

Capsule: drink 300ml of water when taking the medicine

Effervescent tablet: dissolve in 150ml warm water

Pill: drink 150ml of water when taking the medicine

Drink plenty of fluids after taking this medicine

Stomach irritating drugs: mainly include aspirin, prednisone and other drugs. Drinking more water can dilute its concentration in the stomach and protect our stomach.

Capsule-type drugs are easy to adhere to the stomach wall, and the melted drugs cannot be dispersed evenly, resulting in high local concentration to stimulate the gastric mucosa. Drink plenty of water to help the medicine work.

Antibacterial drugs: mainly include synthetic sulfonamides, aminoglycoside streptomycin, gentamicin, kanamycin, amikacin and other drugs. Its metabolites are mainly excreted by the kidneys, and the higher the concentration, the greater the toxicity to the kidneys. If its concentration in urine is high, insoluble crystals are easily precipitated in urine, causing urinary system damage, crystalluria, hematuria, dysuria, etc. Therefore, it is advisable to drink a lot of water during taking the medicine, so that the daily urine output should be controlled at more than 2000 ml, so that the crystals can be washed away with urine.

Salt laxatives, antipyretic analgesics: mainly include magnesium sulfate and cold medicines containing paracetamol. After taking these medicines, the body will sweat a lot and become dehydrated. Replenish water in time to prevent water and salt metabolism disorders.

Bisphosphonates: mainly include alendronate, pamidronate and other drugs. When used in the treatment of hypercalcemia, fluid replacement should be noted due to electrolyte disturbance and water loss.

Protease inhibitors: mainly include saquinavir, atazanavir and other drugs. Such drugs can lead to the formation of urethral or kidney stones. During treatment, adequate hydration therapy should be ensured to avoid the occurrence of urinary stones, and daily water intake should be increased.

Anti-gout drugs: Drink more water when taking uricosuric drugs, such as benzbromarone or allopurinol. In order to reduce the risk of uric acid stone formation in gout patients, the amount of fluid intake Not less than 2000ml, and supplement with sodium bicarbonate to keep urine alkaline, or supplement with potassium citrate to prevent kidney stones.

Anti-asthmatic drugs: mainly include theophylline, aminophylline, dihyprophylline and other drugs, because they can increase renal blood flow, have a diuretic effect, and increase the amount of urine, which is easy to cause Dehydration, dry mouth, polyuria or heart palpitations occur; therefore, it is advisable to replenish water in moderation.

choleretic drugs: choleretic drugs can promote bile secretion and excretion, but ursodeoxycholic acid in choleretic drugs can cause excessive bile secretion and diarrhea after taking Drink as much water as possible to avoid dehydration from excessive diarrhea.

Limited or no water after serving

Antiacid and gastric mucosal protection drugs:

1. Traditional Chinese Medicine. Taking traditional Chinese medicine is not recommended to be diluted with water. The amount of traditional Chinese medicine liquid is 150-200 ml per time, twice a day. If the amount of liquid is too much, drinking water again will cause the concentration of the liquid to be insufficient, and it will also cause the stomach to be full. If the liquid is small and strong, and the taste is extremely bitter, you can take it with a small amount of warm water, or rinse your mouth directly to reduce the irritation of the bitter taste to the oral cavity.

2. Mainly include sucralfate, potassium bismuth citrate, colloidal bismuth pectin and other drugs. Generally, only 50ml of water is required for administration, and it is not advisable to drink or eat within half an hour before and after taking the medicine.

3. Stomach medicines that are directly chewed and swallowed, mainly including aluminum hydroxide and other medicines. Prevents damage to the protective film that the drug forms on the damaged gastric mucosa.

Antidiuretics: mainly include drugs such as desmopressin. Limit drinking water 1 hour before and 8 hours after taking the medicine, otherwise it is easy to cause water and sodium retention, edema, etc.

Peripheral cough suppressants:

1. Mainly include more viscous drugs such as compound licorice mixture, cough syrup, etc. It will stick to the throat, and drinking a lot of water will reduce the local drug concentration and affect the efficacy of the drug. Therefore, it is not advisable to drink water immediately after taking the medicine, in order to facilitate the formation of the protective film, and drink water at least half an hour after taking the medicine.

2. Lozenges, etc. Drinking too much water will weaken its throat moisturizing effect and protective effect on the throat mucosa.

Drugs for the prevention of angina pectoris: mainly include nitroglycerin tablets, Shexiang Baoxin Pills and other drugs that can be absorbed by the sublingual vein and cannot be swallowed. No need to take with water.

Do not take hot water

Vitamins: mainly include vitamin C, vitamin B1, vitamin B2, etc., because of their unstable nature, they are easily destroyed by heat and lose their efficacy.

Digestive aids: mainly include pepsin mixture, trypsin, multi-enzyme tablets, etc.

Containing active bacteria: mainly including compound lactic acid bacteria nutrients, bifidobacteria triple viable bacteria capsules, etc. Active bacteria are destroyed when exposed to heat.

Live vaccines: mainly include polio sugar pills, etc. (For more news, please pay attention to Yangcheng Pie

Source | Yangcheng Evening News·Yangcheng Pie

Photo | Yangcheng Evening News Data Map

Editor | Lin Qingqing

Proofreading | Peng Jiye