In recent years, with the sudden increase of people’s life, study, and work pressure, the prevalence, incidence and potential trend of depression in my country have been increasing. The phenomenon of severe mental disorders such as hallucinations, delusions and other adverse clinical outcomes is also increasing.
Currently, drug therapy is the most commonly used and effective treatment for patients with depression, taking anti-anxiety and antidepressant drugs can significantly improve The patient’s persistent depression, anxiety, low mood, and sleep disturbance and other symptoms.
Many studies have shown that depressed patients have low mood and decreased interest , pessimistic thinking, poor sleep quality and other primary symptoms are often combined with varying degrees of anxiety.
To a certain extent, this leads to more complex conditions and more difficult treatment for patients with depression, which has serious adverse effects on patients’ life and work, and has a negative impact on the overall psychological State and life functions all have a relatively large negative impact.
< p data-track="6">Paxil, as a 5-HT reuptake inhibitor, can selectively inhibit 5-HT by affecting the presynaptic membrane of neurons The purpose of reuptake and increase the concentration of 5-HT in serum and cerebrospinal fluid, so as to enhance the effect of nerve impulse conduction.
It can also achieve the effect of repairing apoptotic neurons and antidepressant by regulating the expression of brain-derived neurotrophic factor.It is currently clinically used to treat all ages One of the preferred medications for depression.
Clinical studies at home and abroad have shown that simple application of paroxetine The effective rate of treating depression patients can reach more than 62%, while the relief rate of depression and anxiety symptoms exceeds 30%, and compared with other The antidepressant drug, paroxetine, has relatively little effect on human cholinergic and adrenergic receptors, so paroxetine Compared with other antidepressants, the application of antidepressants has advantages in terms of curative effect and safety.
In order to further improve the effectiveness and safety of depression treatment, paroxetine is usually used in combination with other drugs or methods.
Here we have to mention its good partner: Buspirone is a new azapirone anti- Anxiety drug has selective affinity for 5-HT1A receptors and is a presynaptic 5-HT1A receptor partial agonist, which can improve the vitality of the brain nervous system and exert a good anti-anxiety effect.
Currently it has been confirmed that buspirone has certain adjuvant effect in conventional antidepressant drug treatment for depression.The effect is, plays an important role in improving the sensitivity of antidepressant treatment and the effective rate of treatment of comorbidities such as anxiety symptoms and sexual dysfunction, However, there are still some controversies about the reasonable dosage of buspirone.
There are also research results showing that using The 40 mg/d dose of buspirone can further reduce the anxiety and depression scores of patients compared with 20 mg/d buspirone while ensuring the curative effect and safety. It has important clinical significance.It can also be used in the clinical treatment of treatment-resistant depression and depression patients with severe anxiety symptoms. It will not increase the risk of adverse drug reactions of buspirone.
Overall, Buspirone Combining paroxetine in the treatment of depression can effectively improve the symptoms of anxiety and depression in patients, without significantly increasing adverse drug reactions, with reliable curative effect and good safety.
I am Director Liu, what other medicines do you want to know about? Can give or leave a message.