Adiponectin secreted by adipocytes, its importance for metabolic health, and how to increase adiponectin levels

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I share a concept that Being fat is a sign of health because your fat cells can also get bigger and store excess calories that help your body share, without causing heat poisoning.

(Above: The video screenshot of the human body getting fat is shared↑)

If you’re getting older and not gaining weight, it means your metabolism is compromised because your fat cells are degraded and can’t store more calories strong>.

It can only be stored around the internal organs, diabetes, and heart disease.

We all know that fat people are more likely to develop diabetes and thin people are less likely to look healthier.

However, it cannot be said with absolute certainty, some fat people are healthier than thin people.

Someone once did an experiment to turn a mouse into a giant mouse by a method, equivalent to 800 pounds of human beings.

However, the mice were found to be healthy and had no metabolic problems.

Many people think it’s incredible that being so fat is still healthy. In today’s article, let’s talk about:

Adiponectin secreted by adipocytes is important for metabolic health.

Adipose cells, adiponectin: key to metabolism

Speaking of fat cells, I have to mention this expert. He is the recipient of the Banting Award (ADA’s highest honor), Dr. Philipp Scherer, director of the University of Texas Diabetes Research Center, and a well-known Expert in fat cell research.

He has been studying fat cells for the past 20 years.

In 1995, he discovered that a specific molecule secreted by fat cells called adiponectin, this protein affects various metabolic processes and protects Cells are protected from inflammation and apoptosis (programmed cell death).

By making fat cells larger and helping the body store calories, it enables the body to adapt to excess caloric supply and ensures metabolic flexibility.

Adipose cells are very active and secrete numerous signaling molecules that affect every tissue.

White fat cells, which produce and release adiponectin (Other types of cells can also be skeletal muscle cells, cardiomyocytes, and endothelial cells.)

White adipose tissue is the main type of fat in the body, and it is located under the skin (subcutaneous fat), around internal organs (visceral fat), and bones (bone marrow fat).

Most people think that if you gain weight, the fat cells become larger, and the higher the adiponectin.

And our common sense thinking, in general, obese people have lower levels of adiponectin.

→High adiponectin, mice are fat, but healthy

Dr. Scherer’s lab injected large amounts of adiponectin into mice, and theyIt was initially expected that the mice would not get too obese, because adiponectin would decline as the mice became obese.

But, on the contrary, the number of fat cells in the mice skyrocketed, resulting in the fattest mice ever, roughly equivalent to a 800-pound ( 363 kg).

What’s even more amazing is that despite their fatness, the mice were remarkably healthy and free of diabetes!

So, this simple study tells me that metabolic health doesn’t seem to have much to do with being fat or not, but rather adiponectin and insulin sensitivity.

Adiponectin has been studied for the last two decades, it is responsible for signaling between organs, it can improve increase insulin sensitivity, Reduce inflammation.

→Adiponectin and insulin sensitivity, inflammation

How are dead cells damaged? In the process of ordinary people getting fat, fat cells expand and become larger, and blood vessels must develop accordingly to provide oxygen.

Insufficient local oxygen supply prevents blood vessels from keeping up with expanding tissue, causing various problems in its development.

Fibrosis caused by hypoxia, leads to increased cellular pressure and tissue necrosis (dead cells).

The remnants of dead fat cells attract white blood cells (macrophages) to clean up the mess, but this can trigger tissue inflammation.

This inflammation, if not addressed, can lead to insulin resistance.

Metabolic health, the ability to tolerate a high-sugar or high-fat diet, is associated with healthy adipose tissue.

Mice with the aforementioned artificially increased adiponectin levels had adipose tissue The fibrosis level was low and the blood vessels were normal.

Adiponectin plays its role in improving insulin sensitivity in the following ways:

Therefore, improving adiponectin levels is key to adipocyte and metabolic health.

How to increase adiponectin levels?

Adiponectin is secreted by adipocytes, however, not more fat means more adiponectin.

Actually, as we’ve seen, the larger the fat cells, the fatder you are, and the lower adiponectin levels.

However, some obese people also have high adiponectin levels and healthy metabolism, because there are ways to increase adiponectin levels.

Therefore, the relationship between obesity and metabolic health is not so absolute, your adiponectin level is the key.

How to increase adiponectin level?

→High-intensity exercise

We see that although many people are fat, they are not high in fat, and various metabolic indicators are normal, even healthier than those who are not fat.

The main reason is that they love to exercise, and exercise can increase adiponectin levels.

A study of 26 overweight men found that adiponectin levels rose 260% after 1 week.

In addition, you can passReducing body fat, especially visceral fat, through exercise can increase adiponectin levels.

→Fasting increases adiponectin levels

Fasting helps with insulin sensitivity, everyone knows that.

A study found that fasting during Ramadan led to increased levels of adiponectin, which may help improve metabolic stress caused by insulin resistance in men with predisposing factors for type 2 diabetes.

Therefore, proper hunger is very important for metabolic health.

→Cold exposure increases adiponectin levels

Chilling is exposing oneself to cold temperatures, and studies have found that adiponectin levels increased by about 70% during chilling after low and high carb diets.

120 minutes of chilling resulted in a significant increase in adiponectin levels in young healthy men, and the increase in adiponectin levels observed during chilling was suppressed by sugar intake.

Low temperature increases adiponectin levels, inducing the conversion of white fat to beige fat, which improves metabolism and increases adiponectin levels.

Adiponectin is one of the few signal transduction factors that induces “rice degeneration” in white adipose tissue.

→Omega-3 supplementation increases adiponectin

Omega-3 can reduce inflammation and increase adiponectin levels, and the study found that 61 polycystic patients who supplemented with omega-3 had significantly higher levels of adiponectin.

→Low-sugar and ketogenic diets increase adiponectin levels

Glucose control is particularly critical to fat cell health, and has been a major means of improving metabolic health in recent years.

Studies have found that adiponectin levels are greatly increased in adolescents and children after a ketogenic diet.

→Other adiponectin-boosting supplements

Some ingredients can increase the level of adiponectin. Now studies have found that berberine, curcumin, resveratrol, astaxanthin, vitamin D and other ingredients can increase the level of adiponectin. Adiponectin.

Key Thin Dragon Says

Adiponectin is a protein secreted by adipose tissue that has been studied for over 20 years for its anti-inflammatory, anti-atherosclerotic and anti-diabetic properties.

It’s important for metabolic health. If you want your fat cells to be metabolically healthy, you can find ways to increase adiponectin levels, so it doesn’t matter if you are a little fat.

Adipose cells function well and excess calories are stored in adipose tissue.

If not, there is energy poisoning and impaired metabolism.

In addition to storing energy, fat cells secrete adiponectin, which affects metabolic processes in the body, increases insulin sensitivity, and reduces inflammation.

We don’t have to blindly pursue being too thin. There are healthy fat people and unhealthy thin people. Metabolic health is more important than body shape.

We look forward to more research on adiponectin in the future, and even products that can be injected into our fat cells to directly help us improve metabolic health.