Source:Voice of Medicine
“Cefs just drink, just walk away”, many people don’t take it seriously, but sometimes it’s really not a joke!
Why can cephalosporin + wine kill people? The culprit behind it is the disulfiram reaction!
Recently, the verdict of an extramarital murder case has sparked heated discussions among netizens.
Huang, a woman from Henan, colluded with her lover to murder her husband. The reason was to achieve the purpose of living together with her lover.
During April to May 2021, Huang and his lover bought cephalosporins several times, and then let their lover and their husband drink alcohol, and took the opportunity to secretly put the cephalosporin in. During the meal of the husband, he wants to die. Then he put cephalosporin into her husband’s diet many times, trying to cause her husband’s death.
After the incident, the two were arrested. Recently, the court sentenced both of them to two years in prison for intentional homicide.
How much hatred is this? “Cef and wine, go away” has never been a false name! All because when the two collide, a disulfiram reaction occurs!
What is disulfiram reaction?
Disulfiram reaction A series of reactions lead to “accumulation of acetaldehyde” in the body, resulting in a poisoning reaction.
Symptoms of poisoning appear within 15-30 minutes of usually taking alcohol or taking alcohol, including facial flushing , Eye congestion, blurred vision, headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, etc.
Severe cases can lead to myocardial infarction, acute heart failure, acute liver injury, convulsions (convulsions) and death, etc. . The elderly, children, patients with cardiovascular and cerebrovascular diseases and those with alcohol allergies are at greater risk.
Which drugs may cause this reaction
Drugs that have been confirmed to cause disulfiram reactions include:
1. Cephalosporins: some drugs with the word “cephalosporin” in their names, such as cefoperazone, cefamandole, cefotiam, cefnicil, cefotetan, cefmethan oxime and so on.
＊ Some cephalosporins do not react with disulfiram, but it is difficult for non-professionals to distinguish them, so it is best not to interact with alcoholSame service.
2, nitroimidazoles (belonging to antibiotics): metronidazole, tinidazole , ornidazole, etc.
3. Nitrofurans (belonging to antibacterial drugs): nitrofurantoin, furazolidone, etc.
4. Antidiabetic drugs (including insulin injections): Glibenclamide, Glipizide, Gliclazide, Gliquidone, Glimepiride, Phenformin, etc.
＊ Taking hypoglycemic drugs with alcohol may also cause hypoglycemia
5, Others: chloramphenicol, isoniazid (anti-tuberculosis drug), warfarin (anti-coagulant drug), ketoconazole (anti-fungal drug), etc.
Precautions for medication: Do not take the above drugs within 24 hours after drinking alcohol. Among them, do not drink alcohol during the course of taking antibiotics such as cephalosporins and within 7 days after stopping the drug. For drugs that require long-term use, it is best to abstain from alcohol.
It’s not just about alcohol. If you are not careful in life, you may encounter some foods and medicines that contain alcohol. We should also pay attention to:
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Alcohol-containing foods: Drunken shrimp, drunken crab, boozy chocolate, fermented bean curd, beer duck, egg yolk pie, etc.
Alcohol-containing drugs: Compound Licorice Oral Liquid, Huoxiangzhengqi Water, some drug injections, some skin-applied cosmetics, ointments, etc. There is “alcohol” or “ethanol”).
> What other medicines cannot be taken with alcohol?
In addition to drugs that may cause disulfiram reactions, there are also drugs that may be taken with alcohol. May increase adverse reactions or even dangerous:
1, sleeping pills + alcohol – be careful of “wake up”
Including: phenobarbital, chloral hydrate, diazepam, chlordiazepoxide, estazolam, zolpidem, etc.
Reason: sedative and sleeping pills are originally It has an inhibitory effect on the brain, and alcohol will aggravate this inhibition, which may cause patients to suffer from critical conditions such as coma, shock, and respiratory failure.
2, analgesics + wine – “stomach bleeding” beckons to you
Including: aspirin, paracetamol, ibuprofen and other drugs with “pain relief” or “fever reduction” effects.
Reason: This kind of “NSAIDs” mainly irritates the gastric mucosa. With the synergy of alcohol, the superposition of the two may cause gastric ulcers , gastritis, and even stomach bleeding.
3. Antihypertensive drugs + alcohol — beware of “hypotensive shock”
Including: reserpine, captopril, nifedipine Equal
Reason: Some antihypertensive drugs and alcohol may cause vasodilation, hypotension, and even shock, which is life-threatening. Some antihypertensive drugs and alcohol may cause blood pressure to soar, which can seriously lead to cerebral hemorrhage.
4. Antidepressants + alcohol–use alcohol to drown your sorrows and make your sorrows worse
Including: sertraline, imipramine, amitripty Lin, doxepin, fluvoxamine, citalopram, foxetine, paroxetine, etc.
Reason: Similar to sleeping drugs, taking it with alcohol will Increase the inhibitory effect on the brain center, and produce adverse reactions, and even reduce the efficacy of the drug and aggravate the disease.
Do you feel that you can’t remember so many medicines? It doesn’t matter, as long as you remember “drinking without taking medicine, taking medicine without drinking” is enough, and resolutely do not drink while taking medicine, in order to ensure that everything is safe.
Eating cephalosporin and accidentally drinking?
3. Drink plenty of water to dilute it.
Alcohol concentration, accelerates alcohol metabolism.
* The premise of inducing vomiting and drinking water is mild. If you have difficulty breathing, blindly inducing vomiting or drinking water may cause suffocation.
4. V-shaped position
For patients with dyspnea or even coma shock, people around them should unbutton their clothes while calling for help in time. Or scarf, so that it is lying on its back with head raised 10 to 15 degrees, feet 20 to 30 degrees, and head turned to one side.
In clinical practice, there are not many cases of death due to disulfiram reaction. Because no one can guarantee that they must be the “majority” who can save themselves from danger…
If you don’t know or want to know about medication, please go to the medication consultation center of the hospital Consult a pharmacist.
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