Anemia due to liver disease is a complication of anemia that occurs during the course of liver disease and is common in most patients with chronic liver disease. Anemia caused by liver disease is most common in alcoholic cirrhosis, posthepatitis cirrhosis, biliary cirrhosis, postnecrosis cirrhosis, and hepatolenticular degeneration.
The pathogenesis of anemia of liver disease is not fully understood and is related to the following factors:< /span>
(1) Lack of hematopoietic raw materials: the liver is an important organ of metabolism, The maintenance of normal physiological function of the blood system also plays an important role.
including: ①reserve of hematopoietic raw materials: ②synthesis of coagulation factors; 3 Secretes some erythropoietin. Therefore, when the above-mentioned functions are impaired in liver disease, folic acid and vitamin B12 deficiency can lead to megaloblastic anemia; blood coagulation disorders can lead to hemorrhage.
(2) The survival time of red blood cells is shortened.
(3) Decreased bone marrow hematopoietic function: plasma iron in most patients with liver disease The turnover rate, erythrocyte iron utilization rate, and erythrocyte iron turnover rate were normal or decreased, indicating that the bone marrow hematopoietic function was decreased.
(4) Increased plasma volume: most patients with chronic liver disease have anemia, Its plasma volume is about 15% higher than that of normal people, and some anemia patients do not reduce the red blood cell volume, so blood dilution is also one of the reasons for liver disease anemia.
(5) Bleeding: 24%~75% of patients with liver cirrhosis complicated with bleeding %, the main site of bleeding in patients with alcoholic liver cirrhosis is the gastrointestinal tract, followed by hemorrhoids and uterine bleeding.
Bibliography: Deng Jiadong Clinical Hematology, Williams Hematology, Hematology Clinical Prescription Manual “Analysis of Difficult Problems in Hematology”, “Hematology Chief Physician’s Ward Round Record”, “Hematology Clinician Questions and Answers”, “Chinese Medicine Hematology Attending Physician Questions and Answers”, “Hematology”, “Diagnosis and Treatment of Blood System Diseases”, “Hematology Diagnosis and Curative Effect” Standard”, “Hematology of Traditional Chinese Medicine”, “Diagnostic Atlas of Blood Cell Morphology” intrusion pictures from the Internet