In Dr. Li’s opinion, the most effective drug for the treatment of premature ejaculation is dapoxetine. As the only prescription drug approved for the treatment of premature ejaculation in men, is it exaggerated? Today, Dr. Li will take you to understand the following it!
How does dapoxetine work?
Dapoxetine is a common clinical antidepressant in terms of its medicinal chemical structure and drug classification. They are all selective serotonin reuptake inhibitors. Similar drugs to fluoxetine and paroxetine.
How can an antidepressant treat premature ejaculation? Don’t worry, see below.
Male ejaculation is a series of reflex activities composed of sensors, motor central nervous system and spinal nervous system, an advanced neural network composed of central nervous system and spinal nervous system control. The central neurotransmitter serotonin, dopamine and other substances and their corresponding receptors are mainly concentrated on the firing nerve reflex, so they have a good regulating effect.
Dapoxetine and other drugs can effectively inhibit the intake of serotonin in the presynaptic membrane, activate the receptors associated with the posterior membrane, increase the relevant threshold, and prolong the time. In particular, dapoxetine, through the above-mentioned mechanism, can enhance the latency of neuronal reflexes in relevant parts.
In general, peak plasma concentrations of dapoxetine can be reached within 1.4 to 2 hours after administration. Twenty-four hours after a single dose, the plasma concentration was 0.5% of the peak concentration. Steady-state plasma concentrations can be reached after 4 days of continuous administration. Pharmacokinetics is not affected by multiple administrations, and dapoxetine is in an ionic state after being absorbed by the human body, and can rapidly form systemic distribution.
Therefore, in improving male-related dysfunction, dapoxetine can be taken 1 to 3 hours before activity because it has the above characteristics and can prolong the time. Therefore, it is the only drug clinically approved for related indications in many countries.
Is dapoxetine dependent?
I believe many friends are more concerned about this issue. In fact, no, relevant clinical studies have also been analyzed and found that the proportion of patients with withdrawal syndrome is about 3.0%, 1.1% and 1.3%. There was no significant difference in the different groups of patients taking dapoxetine, the possibility of withdrawal syndrome is very small, especially when it is taken on demand, there is no continuous stimulation of the relevant receptors, which can reduce the serotonin receptors. Desensitization, let alone medication dependence.
3 precautions for dapoxetine use
1. Choose long-term use or long-term use Take it as needed?
For dapoxetine, long-term daily and as-needed options are acceptable. Due to its rapid absorption and rapid removal, dapoxetine can be taken as needed prior to activity. If you need to take the medicine every day in combination with the specific situation, it can also play a role in improving the efficiency of related problems of male dysfunction.
Therefore, it is recommended to consult a doctor to determine whether to take it as needed or daily as a course of treatment according to the actual situation. Another point to point out is that diet can have a slight effect on the efficacy of dapoxetine. For friends who take it on demand, it is best to choose to take it on an empty stomach.
2. Pay attention to the risk of adverse drug reactions
Although dapoxetine is good , but it also has its own adverse effects. For friends who choose to use dapoxetine, they should also pay attention to the risk of adverse drug reactions. The most common adverse reactions of dapoxetine include abdominal pain, diarrhea, headache, dizziness, insomnia, drowsiness, fatigue, etc. Some patients will experience erectile dysfunction, but most adverse effects are mild to moderate and generally acceptable.
Relevant studies also found that with the increase of drug dose, the incidence of adverse reactions of dapoxetine will also greatly increase, and the daily use of dapoxetine is higher than that of on-demand use. , Dapoxetine should be selected according to the actual situation to suit their own drug regimen.
3. Watch out for drug interactions
Studies show that dapoxetine has a synergistic effect with trouble , can reduce trouble and analgesic use, while alcohol has less effect on dapoxetine. In general, drinking alcohol in small amounts (up to 30 grams of alcohol) will not affect the medication. However, in the process of taking the medicine, you should still pay attention not to drink alcohol as much as possible, let alone excessive drinking, so as not to cause unnecessary health problems.
For friends who take strong liver drug enzyme CYP3A4 inhibitors, such as ketoconazole, clarithromycin, amiodarone, fluconazole, atonavir, Mitidine, etc., these drugs can affect the metabolism of dapoxetine, increase its exposure, avoid taking dapoxetine, and avoid unnecessary drug risks.
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