Lao Zhang, a hypertensive patient, has been taking nifedipine for nearly 10 years, and his blood pressure can be controlled, but in the last two years, he suddenly has dizziness and other low levels. The performance of blood pressure, after consulting a doctor in time, change the antihypertensive drug to amlodipine besylate, and Zhang’s blood pressure has remained at 130/80mmHg after changing the drug.

But another colleague of Lao Zhang was not so lucky. The colleague is 53 years old and diagnosed with hypertension relatively late. He was resistant to taking medication at first, nilfedipine did not start until his blood pressure reached 180mmHg.

My colleague not only takes medicine late, but also often does not follow the doctor’s orders, often forgets to take medicine. This is the case for a long time.He suffers from sudden The cerebral hemorrhage was sent to the hospital. Although he was rescued, he could not take care of himself in the future.

Hypertensive patients must be no strangers to amlodipine and nifedipine. Today Xiaojiu talks about the advantages and disadvantages, side effects and coping methods of these two drugs.

First, amlodipine and nifedipine are “in their own way”

“XX Dipine” is a commonly used antihypertensive drug of calcium channel blocker, which mainly reduces blood pressure by dilating blood vessels. Representative drugs include amlodipine and nifedipine.

Nifedipine is divided into ordinary tablets, sustained-release tablets, and controlled-release tablets. The most commonly used is controlled-release tablets. Nifedipine ordinary tablet is a short-acting antihypertensive drug, and it is made into sustained-release or controlled-release tablets by pharmaceutical technology, you can slow down and prolong the onset of the drug.

Amlodipine has a mild onset of action and fewer adverse reactions, so it is more widely used. As a long-acting antihypertensive drug, amlodipine has a metabolic half-life of more than 30 hours. Usuallyamlodipine is taken before or after a meal, not just in the early morning.

Dipine antihypertensive drugs are commonly used in hypertensive patients. These antihypertensive drugs have seven advantages:

1. If hypertensive patients need to take non-steroidal anti-inflammatory drugs, At this time, taking dipine antihypertensive drugs at the same time will not affect the efficacy.
2. Dipines can improve myocardial blood supply in addition to reducing blood pressure and dilating blood vessels, and are suitable for patients with hypertension and angina pectoris.
3. Dipine antihypertensive drugs do not affect glucose and lipid metabolism, so they are also suitable for patients with hypertension and diabetes.
4. Long-term use of dipine antihypertensive drugs also has anti-atherosclerosis effect.
5. Dipine antihypertensive drugs have good antihypertensive effect on elderly patients.
6. Suitable for hypertensive patients with high salt sensitivity or high-salt diet.
7. Under the guidance of a doctor, it can be used as one of the few optional antihypertensive drugs during pregnancy.

Second, long-term use of amlodipine and nifedipine, there may be five major Harm

Hypertensive patients generally need to take medicine for life, and although the antihypertensive drugs they take can lower blood pressure, they may have certain side effects. Generally, after taking dipine antihypertensive drugs, the following five adverse reactions may occur:

•edema

Dipine antihypertensive drugs, as calcium channel blockers, dilate the small arteries before the capillaries, which may cause edema of the ankles and legs.

Generally mild edema can be relieved by raising the lower limbs or reducing the drug under the guidance of a doctor, while severe edema or unbearable edema can be changed to other lower extremities under the guidance of a doctor. Press medicine.

•Constipation

Calcium channel blockers affect intestinal smooth muscle calcium levels transport, which may cause constipation in some patients.

It is recommended to drink more water, eat more cellulose-rich fruits and vegetables, and moderate exercise while taking dipine antihypertensive drugs, which can generally be relieved. If the constipation is severe, the medicine should be changed under the guidance of the doctor.

•palpitations

Dipine antihypertensive drugs can stimulate the central sympathetic The patient’s reflex heart rate is accelerated, resulting in the performance of palpitations. If the palpitations are serious, the doctor should be consulted to adjust the antihypertensive drug regimen.

•Face flushing

Dipine antihypertensive drugs lower blood pressure by dilating blood vessels. Therefore, some patients may experience facial flushing after taking them. If the symptoms are mild, you can continue to observe them. If they are serious, you should consult a doctor.

•gingival hyperplasia

gingival hyperplasia is one of the adverse reactions of most dipine antihypertensive drugs. The problem of gingival hyperplasia is usually relieved after 1 to 8 weeks after the drug is stopped. If the situation is serious, it is best to go to the dentist in time.

ThatThese side effects may occur in some people, but most are not serious. And most of the side effects occur in the first period of taking the medicine, and will not increase with the time of taking the medicine, and some of them will gradually reduce or disappear with the extension of the taking time. If the side effects are obvious, you need to ask your doctor whether to change the decompression medicine.

3. How to choose? It is very important to find the right medicine.

It is also a dipine antihypertensive drug. Who should I choose between amlodipine and nifedipine? What are the advantages and disadvantages of the two?

Amlodipine

Advantages: Because of its long half-life, patients only need to take it a day Once, the action is smooth and convenient. Another drug can be divided, the drug accumulation in the body, and occasional missed dose has little effect.

Disadvantages: Amlodipine is slow to take effect, and it may feel that the antihypertensive effect is not obvious at the beginning. Usually, the antihypertensive effect will be obvious after taking it for 1-2 weeks. Taking the medicine for 6-8 weeks has the strongest decompression effect.

Recommendation: Hypertensive patients with poor compliance and easy to miss antihypertensive drugs are more suitable for amlodipine with a long half-life.

nifedipine

Advantages: The plasma concentration fluctuation of nifedipine controlled-release tablets is relatively small, compared with amlodipine, nifedipine controlled-release tablets control The rate of blood pressure is faster, and the best blood pressure effect can be achieved after taking the medicine for 3-5 days.

Disadvantages: Nifedipine ordinary tablets have a rapid antihypertensive effect, easily stimulate the sympathetic nerve, and may produce adverse reactions. In addition, the antihypertensive action time is short and unstable, and the situation of large blood pressure fluctuations may easily occur.

Suggestions:Hypertensive patients with severe elevated blood pressure or who need rapid blood pressure reduction can choose to take controlled-release nifedipine piece.

There are differences in medication for different groups, It is contraindicated for those allergic to dipines, and for cardiogenic shock. Pregnant women, lactating women and children should use it with caution.

Hypertension, as the most common chronic disease, requires lifelong medication to keep blood pressure stable, so pay special attention to regular medication and never stop taking it by yourself! Amlodipine and nifedipine have their own advantages and disadvantages. If you experience discomfort during taking the medicine, you should consult your doctor in time.

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