No.
01
The important role of viruses in the gut-brain axis
Original: The gut-brain axis goes viral
Cell Host Microbe IF:20.813
A large number of recent studies have demonstrated the importance of the host microbiome for host neural function. Mayberis-Perxachs and Castells-Nobau et al. revealed the role of gut-parasitic bacteriophages in microbial composition and metabolism, and their downstream effects on neural gene expression and cognition.
The microbiome in an organism plays an important role in many aspects of host physiology. Among these microorganisms, the number of viruses is about 10 times that of bacteria. The basis of structure and function in humans, including symbiotic microbial populations in the human body.
While the gut microbiome has been studied for decades, the impact of phage activity in the gut on host neurological function and physiology remains to be studied.
The association of the virome with aging, disease, and/or diet has been reported.
Non-commensal viruses (that is, human pathogens in the traditional sense) are associated with neurological diseases, such as the association of EBV with multiple sclerosis.
In addition, a recent study conducted an association analysis of faecal commensal phages with a series of cognitive measures and found that levels of specific tailed phages were positively associated with measures of executive function, whereas faecal phagocytosis Elevated levels of microphages correlate with decreased executive function.
Since phages are generally not thought to directly affect human physiology, studies of the phageome, bacterial population composition, and metabolites can shed light on whether phages affect cognition or whether these associations are merely episodic.
At the same time, the phage group and the host gene expression profile can also be analyzed at the same time to find the effect of the phage group change on the host gene expression.
This paper provides a new perspective on the interrelationships between enterovirome, metabolism, and host cognitive processes.
No.
02
Longitudinal analysis reveals high incidence of EBV associated with multiple sclerosis
Original: Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
ScienceIF:47.7
Multiple sclerosis (MS) is a chronic infectious demyelinating disease of the central nervous system of unknown etiology. This study included 10 million U.S. military service members who were used to test the hypothesis that EBV infection causes MS. A 20-year follow-up study was conducted, of which 955 were diagnosed with MS during service. A total of 801 MS patients and 1566 controls had samples at different time points for EBV infection status. The age of most individuals at the time of first blood collection
The risk of MS is 32-fold increased with EBV infection, but not with other viruses, including the same circulating cytomegalovirus.
Serological levels of nerve fiber light chain, a marker of neuromyelination degeneration, increased only after EBV seroconversion. These findings could not be explained by known risk factors for MS, suggesting that EBV is the primary causative factor for MS.
This article is from: Gene Help