“Doctor, why does my dad keep taking nifedipine, why does he still have a brain hemorrhage?”< /span>
< /p>
Uncle Wang is 68 years old this year, and he is usually in good health. However, some time ago he always felt dizzy. At first, he thought it was caused by insomnia, but after the insomnia improved, the symptoms of dizziness not only did not ease, but also tended to aggravate. As a last resort, Uncle Wang went to the hospital for treatment.
After the outpatient doctor asked about Uncle Wang’s condition, he measured his blood pressure, and the blood pressure monitor showed 164/98mmHg. In order to rule out the dizziness caused by brain factors, the outpatient doctor performed a CT scan of the head for Uncle Wang. After the test results came out, no obvious abnormality was found. Later, the outpatient doctor told Uncle Wang: If the blood pressure cannot be diagnosed based on the one measurement result, the blood pressure should be measured after returning home. If the blood pressure is too high or the blood pressure exceeds 140/90mmHg for 2 days, then come to the hospital as soon as possible.
Unconsciously, two days later, Uncle Wang’s blood pressure was still high, so he had to come to the hospital for treatment. After the outpatient doctor fully understood the situation of Uncle Wang, he prescribed nifedipine sustained-release tablets.
After a while, Uncle Wang suddenly developed a severe headache. When the family saw that the situation was wrong, they rushed Uncle Wang to the emergency department. After the receiving doctor asked some information about Uncle Wang, he asked him to do a head CT as soon as possible. After the examination results came out, it showed hemorrhage in the left basal ganglia. The initial estimate of the amount of bleeding was about 32ml, and surgery was needed as soon as possible. Uncle Wang’s son was very surprised when he heard this, so he asked the question at the beginning of the article.
Maybe many friends have similar questions to Uncle Wang’s son: Why does he insist on taking nifedipine for sudden cerebral hemorrhage? In order to clear everyone’s doubts, today the doctor’s good words will have a good chat with you about relevant knowledge.
1. How does nifedipine control blood pressure?
Before answering this question, let’s take a look at some knowledge about blood pressure.
Blood pressure, as the name suggests, refers to the pressure of blood on the lining of blood vessels. In the case of constant blood volume, vasoconstriction, increased cardiac contraction, increased heart rate, etc., can increase blood pressure.
This is actually easy to understand. Under the condition of constant blood volume, vasoconstriction will increase the pressure of blood on the inner wall of blood vessels; while cardiac contraction will increase and heart rate will increase. Fast is equivalent to adding gas to a car, so it can also cause blood pressure to rise.
heart
In essence, nifedipine is a calcium antagonist. When people take nifedipine, it can act on ion channels and inhibit calcium ions from outside the heart cells into the heart cells. In this case, the number of calcium ions in the heart will be reduced. After the number of calcium ions in the heart is reduced, the contractility of the heart will be weakened, thereby achieving the effect of lowering blood pressure.
In addition, nifedipine dilates small arteries. When the arterioles are dilated, the resistance of the blood vessels decreases. At the same time, nifedipine also slows down the heart rate. Nifedipine can control blood pressure from multiple mechanisms, and is a drug with good antihypertensive effect.
2. Since nifedipine has a good antihypertensive effect, why does Mr. Wang insist on taking nifedipine but has sudden cerebral hemorrhage? What precautions should I take while taking nifedipine?
After a careful study, I learned that during the period of taking nifedipine, Uncle Wang did not pay attention to two major details. The specific summary is as follows:
❶No formulation of nifedipine is known:
At present, there are mainly three types of nifedipine dosage forms on the market, namely nifedipine ordinary tablets, nifedipine sustained-release tablets, and nifedipine controlled-release tablets.
Nifedipine ordinary tablet is a short-acting antihypertensive drug, so the time of drug action is relatively short. Generally speaking, after people take this dosage form, the concentration of the drug will reach its peak in about 30 minutes, and it will be metabolized in about 4 hours. To stabilize blood pressure, nifedipine regular tablets need to be taken 3 times a day.
Nifedipine Sustained-Release Tablets are moderate-effect preparations, which can be used for 12 hours once taken. Generally, 2 times a day is enough.
Nifedipine controlled-release tablets are long-acting preparations, which use a special process to release nifedipine at a constant rate.
Later I learned that, in order to save some money, Mr. Wang bought a relatively cheap ordinary tablet of nifedipine. After he bought this antihypertensive drug, he did not read the instructions carefully, but took the drug according to the previous dosage of nifedipine sustained-release tablets. We all know that the action time of nifedipine ordinary tablets is relatively short. After the effect of the drug is over, the blood pressure will quickly rebound, which will increase the risk of cerebral hemorrhage.
When buying antihypertensive drugs, we must mainly look at the dosage form and dosage of the drug, try to choose long-acting preparations, and take the medicine strictly according to the instructions.
❷Dosage reduction privately:
p>
Uncle Wang had symptoms of nausea and vomiting while taking antihypertensive drugs, so he reduced the dosage of the drugs. Privately reducing the dose of antihypertensive drugs, itself will increase the risk of cerebral hemorrhage.
For patients with high blood pressure, to reduce the risk of high blood pressure, it is necessary to control blood pressure smoothly. If the dosage of antihypertensive drugs is reduced privately, it may cause blood pressure to rise and fall. Blood pressure rises and falls, just as we bend blood vessels repeatedly. When the blood vessel is bent to a certain extent, it may cause damage to the blood vessel, which may cause cerebral hemorrhage. #health star Plan#
In addition, by reducing the dose of antihypertensive drugs, blood pressure may become uncontrolled meet the target. If the blood pressure is high enough, it may cause the blood vessel to rupture, which is what everyone calls a cerebral hemorrhage. #health2022#
When we take nifedipine, we should pay attention to the dosage form and dosage. Generally speaking, different dosage forms of nifedipine may lead to different dosages. Ordinary nifedipine tablets need to be taken 3 to 4 times a day; sustained-release tablets are taken twice a day; nifedipine controlled-release tablets are taken once a day. #Health Science Contest#
In addition, women allergic to nifedipine, pregnant or during pregnancy, Nifedipine should be contraindicated in patients with cardiogenic shock. Try not to take the same type of antihypertensive drugs (such as amlodipine, felodipine, etc.) while taking nifedipine. During medication, do not add antihypertensive drugs without permission. If blood pressure control is not up to standard, you can also adjust the medication under the guidance of a professional doctor.