Speaking of sildenafil, I believe that most men are familiar with it. It is often used to treat local dysfunction in men and improve men’s physical condition. It is a three-point drug, and sildenafil can also cause side effects when treating diseases. Studies have shown that sildenafil developed by Guo Pfizer can promote the deterioration of abdominal aneurysms.

Why does sildenafil worsen abdominal aortic aneurysm?

Abdominal aortic aneurysm is something that makes the abdominal aorta weakened or bulged. Ruptured abdominal aortic aneurysm is an emergency and survival is less likely. Such diseases are common in older men, especially those with chronic smoking, obesity, high cholesterol and high blood pressure, family cases of abdominal aortic aneurysm, and emphysema.

Some elderly men use sildenafil to improve local function, so the research team studied the inhibition of sildenafil Will PDE5 affect the progression of abdominal aortic aneurysm? The research team induced abdominal aortic aneurysm in mice through surgery, monitored the size of the aorta, and the mice developed abdominal aortic aneurysm 7 days after surgery.

The researchers divided the mice into two groups. Group A was given sildenafil dissolved in water every day. 60-100 mg per kilogram of body weight; group B took normal water. For 4 consecutive weeks, the changes in the size of abdominal aortic aneurysm were observed together. The experimental results showed that compared with the mice in the group B, the abdominal aortic aneurysms of the mice in the group A became larger, with an average width of about 37%, and the degeneration of the elastic fibers increased by 50%.

It can be seen that sildenafil can worsen abdominal aneurysms, possibly because sildenafil disrupts smooth muscle cell contraction and due to work ability.

What is the difference between domestic sildenafil and imported sildenafil?

Domestic sildenafil is cheaper than imported sildenafil, with similar efficacy and safety, and is effective in treating male local dysfunction Almost the same, relatively speaking, domestic sildenafil is cost-effective.

Is long-term sildenafil addictive?

An addictive drug is one that induces pleasure, or relieves pain, and produces dependence and tolerance after taking it. Taking sildenafil does not cause this problem, so you don’t have to worry about being addicted to taking sildenafil for a long time, and it will not cause dependence. However, you should pay attention to the following points during medication.

1. Medication time

It usually takes about an hour for sildenafil to take effect, so the medication time should be arranged one hour before the couple’s life. The efficacy of the drug will be affected by the diet. Eating too full, drinking alcohol and greasy food will weaken the efficacy of the drug, so it should be taken on an empty stomach. If you have just started taking small doses, if there is no effect, you need to increase the dosage appropriately according to the doctor’s instructions or instructions.

2. Cannot be used in combination with nitrates span>

Sildenafil should not be used in combination with nitrates, such as nitroglycerin and Xiaoxintong, otherwise it will cause side effects and cause a sharp drop in blood pressure , and even shock due to hypotension. If the medicine must be taken at the same time because of the disease, the time between the two medicines should be separated by more than 24 hours.

Warm Tips

After the above understanding, Sildenafil should not be taken in patients with aortic aneurysm. Hypotension, or hypertensive patients with blood pressure greater than 170/110 mHg; myocardial infarction or shock and severe arrhythmia within 6 months; unstable angina As well as heart failure, sickle cell anemia, and retinitis pigmentosa patients should not take sildenafil. It is worth reminding that sildenafil should not be taken in males with normal local function to avoid side effects.

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