Beijing News (Reporter Zhang Zhaohui) Recently, the incident of “a woman was sleepy for more than 20 days and found glioma after waking up” has attracted attention. How should glioma be treated? What drugs and methods are available for glioma treatment?
Gliomas are neuroepithelial tumors derived from glial cells of the central nervous system and are a type of solid tumor, including astrocytic tumors (eg, glioblastoma GBM), the most aggressive One of the most common primary brain tumors, the median survival of patients is only 12 to 15 months, despite some curative effects through surgery, chemotherapy, and radiation therapy.
On June 20, 2020, at the GBM Summit Forum of the Glioma Professional Committee of the China Anti-Cancer Association, my country’s first tumor electric field therapy, Aipdun, was announced. The product is used in combination with temozolomide for the treatment of patients with newly diagnosed glioblastoma; as a monotherapy for the treatment of patients with recurrent glioblastoma.
In terms of drug treatment, the Insight database of Dingxiangyuan shows that at present, the drugs that have been approved and marketed at home and abroad for the treatment of glioma include temozolomide capsules, bevacizumab injection, and temozolomide for injection. kind. According to public information, temozolomide is an anti-tumor drug, which can be degraded spontaneously and quickly in the body to produce the active metabolite MTIC, which has anti-tumor effects and is used as a therapeutic drug for adult malignant glioma and malignant melanoma; bevacizumab Monoclonal antibody injection can be used for the treatment of adult patients with recurrent glioblastoma.
According to the statistics of Lilac Garden’s Insight database, currently, domestically listed products include temozolomide capsules produced by Beijing Shuanglu Pharmaceutical Co., Ltd., and bevacizumab injection produced by Suzhou Shengdia Biopharmaceutical Co., Ltd. (trade name Aeritor), bevacizumab injection (trade name Boyuno) from Shandong Boan Biotechnology Co., Ltd., bevacizumab injection from Innovent Biopharmaceutical (Suzhou) Co., Ltd. Liquid (trade name Dayutong) and temozolomide for injection from Jiangsu Hengrui Pharmaceutical Co., Ltd. The listed imported products involve pharmaceutical companies such as Merck & Co., Roche, and Bayer Healthcare.
Currently, there are 11 glioma treatment drugs under research in the world, including bevacizumab injection, ACT001 capsules, oxbitzine fumarate enteric-coated pellets, JL15003 injection, Paxalisib Capsules, ASC40 Tablets, NMS-03305293 Capsules, Enzastaurin Tablets, SDT-101 Maleate Capsules, Temozolomide Capsules, Temozolomide for Injection. Among them, the highest progress of ASC40 tablets of Ascletis Biotechnology (Hangzhou) Co., Ltd. and Enzastaurin tablets of Hangzhou Suoyuan Biopharmaceutical Co., Ltd. are in Phase III clinical stage.
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