Currently in my country, the largest source of uremia is chronic glomerulonephritis (accounting for 35.81%), and among chronic glomerulonephritis, IgA nephropathy accounts for the largest proportion (45%),For every 10 kidney biopsy patients with nephritis, about 5 people have IgA nephropathy.
span>What is IgA Nephropathy?
IgA nephropathy is a kind of nephropathy with a high incidence in Asians. Some people’s gene defects bring a higher risk of IgA nephropathy, coupled with acquired infections and immune disorders. lead to kidney disease.
The huge number of patients with IgA nephropathy has brought about 1 million existing uremia patients to our country, and also brought a heavy burden to the medical system, individual patients and families.
IgA
have the following characteristics:
1. It is more common in young people, and it usually occurs after a cold;
2. It is often accompanied by hematuria;
3. Most patients have serum IgA/C3≥2.1, which can assist in diagnosis;
4. There is no specific drug, and hormones and immunosuppressants generally have limited efficacy;
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5. Progressive progression: about 20% of patients progress to uremia within 10 years; about 40% of patients progress to uremia within 20 years.
If you are no longer a child and have not entered old age, then when renal hematuria is found, IgA nephropathy should be highly suspected.
IgA> span>1. Puli/Sartan+TCM is the basis of treatment
At the time of diagnosis of IgA nephropathy, 40% of the patients are accompanied by hypertension, and as the course of the disease prolongs or As the condition worsens, the incidence of hypertension will increase.
Pril/Sartan drugs can lower blood pressure while protecting the kidneys (reduce glomerular pressure, reduce immune inflammation in the kidneys, thereby reducing urinary protein); traditional Chinese medicine Can reduce proteinuria and hematuria in IgA nephropathy, while reducing the recurrence rate.
2. Hormones/immunosuppressives against the risk of renal failure
If you have been treated with Prix/Sartan+TCM After treatment, the 24-hour urine protein quantification is still greater than 1 g; or if renal biopsy shows obvious inflammatory cell infiltration, mesangial cell proliferation, and cellular crescent formation in the kidney, hormone/immunosuppressive therapy should be initiated.
It is not advisable to use a sufficient amount of hormones, as the side effects are large and the effect is unsatisfactory. “Low-dose corticosteroid + leflunomide” is the preferred immunotherapy regimen, and comprehensive treatment of anti-platelet aggregation, anti-coagulation and fibrinolysis is carried out at the same time.
3. Fish oil
For IgA nephropathy whose treatment effect is not ideal with Puli/Sartan, fish oil is also a Options to consider, most studies have shown that fish oil can reduce urinary protein in patients with IgA nephropathy.
Most IgA kidney disease progresses slowly and does not damage your kidney function quickly, but It is more “grinding”, and it is not an overnight success to drive it away. Patients with mild disease may require treatment for half a year or a year, and patients with severe disease may require several years of treatment. If renal function is impaired, treatment may be required for life.
IgA kidney friends must be patient and follow the doctor’s advice to adhere to the treatment. The ultimate goal is to never progress to uremia for life, and the victory will belong to you in the end!
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