Kidney friends all know that the value of serum creatinine represents kidney function to a certain extent. The normal range does not exceed 140 μmol/L, usually within 100 μmol/L.
Because serum creatinine is affected by diet, physical activity, etc., there will be a small range of fluctuations, usually the fluctuation range is within 20%, and the fluctuation within 10% is the most common.
For example, for a patient with a serum creatinine of 150 μmol/L, the next time the renal function is checked, the serum creatinine may be 140 μmol/L or 160 μmol/L.
The higher the creatinine, the greater the fluctuation. For example, in a patient with a creatinine of 550 μmol/L, the next time the renal function is checked, the serum creatinine may be 500 μmol/L or 600 μmol/L. Such fluctuations are normal, and it is not certain that the condition has changed.
But if the fluctuation range of serum creatinine exceeds 20%, it is not normal. For example, a patient whose serum creatinine is 150 μmol/L, the next time the blood creatinine is checked is 200 μmol/L. L, there are additional reasons to damage kidney function. If the serum creatinine rises by more than 50% within a week, it can be diagnosed as “acute kidney injury”.
What causes creatinine to rise rapidly?
1. The most common reason is the lack of water in the body
The loss of water reduces blood volume and reduces blood supply to the kidneys , renal function decline.
Many conditions can cause dehydration in the body, such as fever, profuse sweating, vomiting and diarrhea, bleeding and blood loss, excessive diuresis, burns and scalds, working in high temperature environments, etc. .
In this case, it is necessary to take timely measures such as drinking water, fluid/blood transfusion, and stopping diuretics, and serum creatinine can basically recover.
2. The main reason for the sharp increase in serum creatinine: infection
Among the factors of acute renal failure, the infected person ranks among the factors First.
The common cold is a common infection caused by a cold virus that is usually minimally harmful and does not cause an increase in serum creatinine. Colds caused by viruses and bacteria are often more harmful, such as influenza, with severe symptoms, such as redness, heat, swelling and pain in the respiratory tract. In addition, gastrointestinal infections such as enteritis and gastritis, and urinary tract infections such as ureteral and renal pelvis infections can also cause increased serum creatinine.
When the patient has symptoms such as cold, gastroenteritis, urinary tract infection, etc., they need to go to the hospital to check the blood routine, urine routine, etc. If there is bacterial infection, they need to use antibiotics and other antibacterial drug.
3. Improper use of medication
The most common drugs that lead to increased serum creatinine in patients with renal disease are diuretics and antihypertensive drugs. If drug-induced renal damage occurs, the drug should be discontinued in time.
There are many kinds of diuretics, which are commonly used in patients with renal disease. In addition, the dose of diuretics is too large and the diuresis is too fast, resulting in a lack of water in the human body. As mentioned above, this is also a kind of kidney damage.
Among the antihypertensive drugs, the most commonly used antihypertensive drugs in patients with renal disease are Pril and Sartan. There is no damage to the kidneys, and it has the effect of protecting the kidneys. However, it may occur that the serum creatinine increases by more than 30% or even 40% after taking Puli or sartan, so the renal function should be closely monitored during initial treatment, especially in patients with renal failure whose serum creatinine has already exceeded the standard.
In addition, compared with the kidney damage caused by antihypertensive drugs, the kidney damage caused by high blood pressure is more common, and not taking antihypertensive drugs is more harmful. inappropriate medication.
In short, when the increase in serum creatinine reaches 20%, the cause should be sought. This cause is usually reversible, and the renal function can be basically restored to the original level.