Uncle Zhao has suffered from high blood pressure for many years, and his blood pressure has been poorly controlled. Renal function must be monitored outside the hospital. Why should kidney function be monitored while taking sartans?

Sartans are one of the most commonly used antihypertensive drugs in clinical practice and are angiotensin receptor antagonists, including losartan, valsartan, telmisartan and irbe Shatan and others. It has the effect of reducing proteinuria and delaying the deterioration of renal function, but it will reduce the glomerular filtration rate when initially administered, which may lead to an increase in serum creatinine.

Hypertensive patients need to recheck their serum creatinine level within 1 to 2 weeks of taking the drug. If the serum creatinine increases by more than 30% from the baseline, the dosage should be reduced or the drug should be discontinued. If the serum creatinine increases by more than 50% compared with the baseline, it is recommended to interrupt the sartan therapy and find out whether there are other reasons for the increase of serum creatinine, such as hypovolemia, renal artery stenosis, etc., until the inducement is removed and the serum creatinine level returns to normal. Initiate sartan therapy. For patients with bilateral or unilateral renal artery stenosis, sartans are contraindicated to lower blood pressure.

Source: Medicine Huluwa