600″>600″>Hangzhou recently Bu Zhangyu, deputy director of the Dermatology Department of the First People’s Hospital, published “A rare case of condyloma acuminatum caused by HPV73 and HPV33 infection” in the authoritative journal “Journal of infection and public health” (IF 7.537 points), reporting a global Rare cases of condyloma acuminatum caused by HPV73 and 33 (the first author is He Beilei, a 21st-level master student at Zhejiang University of Traditional Chinese Medicine).
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On this day, Bu Zhangyu, deputy director of the Department of Dermatology and Venereal Diseases of Hangzhou First People’s Hospital, saidA post-00 Xiaoli came to the expert clinic.
The little girl awkwardly handed over a checklist,explained I was infected with high-risk human papillomavirus (HPV) positive by my boyfriend. Then he asked nervously, “Director Bu, I checked on Baidu, and it seems like this is very rare. What should I do?”
Bu Zhangyu took Xiaoli’s test form and found that the test results were positive for HPV73 and 33, and was surprised. Indeed, this subtype is very rare, and I have encountered it for the first time in my medical career. But fortunately,most immunocompetent young people can improve their immunity by exercising and adjusting their schedules after contracting this subtype. Self-clearing without special treatment .
However, a subsequent physical examination revealed that Lily had vaginal wall and fornix. A large number of “cauliflower-like” vegetations, further pathological biopsy to rule out cervical lesions,and confirmed that these vegetations are “condyloma acuminatum” “.
This made Bu Zhangyu ponder deeply. Based on his experience, condyloma acuminatum is mainly caused by low-risk HPV types 6 and 11, high-risk HPV types 16 and 18, and a very small proportion is related to low-risk HPV types 42, 43, and 44.
The patient in front of him broke the conventional cognition: it turned out that other high-risk subtypes of HPV other than types 16 and 18 also May cause condyloma acuminatum!
According to Bu Zhangyu’s experience, this disease will progress rapidly and urgently needs active treatment.
Bu Zhangyu led the team to formulate a complete diagnosis and treatment plan for Xiaoli. After staged treatment, Xiao Li’s wart was completely removed, and HPV was successfully turned negative.
Male and female
May also cause cancer of the oropharynx, throat, etc.
Bu Zhangyu introduced that HPV is actually very common.There are more than 200 HPV genotypes discovered so far,< /strong>HPV1, 2, 3, 4, 13, etc., which infect the skin of hands and feet, etc., are transmitted through daily contact, causing common warts, flat warts, plantar warts, verrucous epidermal dysplasia, etc. Diseases, these are common diseases in dermatology clinics.
There are more than 40 types of sexually transmitted diseases related to infection of the anogenital mucosa. They are divided into high-risk and low-risk types according to their pathogenicity. Among them, there are about 25 high-risk HPV types, including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 and 73. These subtypes are associated with tumor hyperplasia. It can lead to genital and anal malignancies, such as cervical cancer and cervical intraepithelial neoplasia (CIN), of which about 70% of cervical cancer and penile squamous cell carcinoma are directly related to HPV16 and 18 infection.
For HPV infection, the public and various media mainly focus on cervical intraepithelial neoplasia, cervical cancer and other female-related tumors. But Bu Zhangyu explained that, in fact, these subtypes of HPV can be infected by sexual contact, and both men and women can be infected. Vegetation has the characteristics of fast growth, high transmission rate, and easy recurrence.
“These subtypes of HPV not only infect the genital anal area, but also the mouth, nose, and throat. It can also be infected in special parts such as the abdomen, and can even cause oropharyngeal cancer, laryngeal cancer, vulvar and anal intraepithelial neoplasia and cancer in men and women.”BU Zhang Yu said, “Our team has also published many high-level papers on related cases in recent years.”
In addition, condyloma acuminatum in children is not uncommon in recent years, some of which are caused by HPV infection of the birth canal during childbirth, causing throat papilloma, and some are affected families Indirect contact of members to the child’s perineum.
Therefore, Bu Zhang would like to remind that if you find yourself infected with HPV, in addition to female gynecology, it is also recommended to go to the dermatology department for consultation. Professional doctors rule out whether there are abnormal vegetations and tumor risks in related parts, and both men and women and their sexual partners should also be checked simultaneously.
Have you been vaccinated against HPV and can you rest easy?
The answer is not so
Then some people may ask, if I have completed the HPV vaccination, can I avoid infection?
Bu Zhangyu affirmed that this is not the case.
He introduced that there are currently three main types of HPV preventive vaccines on the market: Bivalent vaccines: For subtypes 16, 18; quadrivalent vaccine: against subtypes 6, 11, 16, 18; nine-valent vaccine: against subtypes 6, 11, 16, 18, 31, 33, 45, 52, 58.
Current studies have shown that the HPV vaccine has better immunity protection, but the HPV vaccine only covers some common subtypes, but other HPV subtypes may also be infected, which we cannot ignore.
In addition, the protection of vaccines is definitely not 100%. In actual clinical work, the team of Deputy Director Bu Zhangyu has encountered many Patients who have been vaccinated but are still infected with the HPV subtypes included in the vaccine, even warts.
“Due to the wide range of mucous membranes and skins infected by HPV, the use of condoms can only reduce the probability of infection, but cannot completely block the transmission of HPV. He said, “Another important point is that the HPV vaccines currently on the market are all preventive vaccines and have no therapeutic effect on patients who have been infected with the relevant HPV subtypes.”
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Finally, Bu Zhangyu emphasized that the key to preventing HPV infection is to avoid unclean sexual contact. In addition to HPV, there are HIV, syphilis, genital herpes, gonorrhea, non-gonococcal urethra Inflammation and many other high-risk sexually transmitted diseases. Even if women who have been vaccinated against HPV are not 100% protected against HPV infection and cervical cancer, they should go to the gynecology department for cervical cancer screening (HPV and TCT examination) regularly to avoid missing the net of fish.
Orange Persimmon Interactive · Urban Express reporter Yu Qianqian
Correspondent Wang Wenting
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