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“Academic Lu Xun” and Rao Yi, President of Capital Medical University, fired again .
The goal this time is to top 2020 Top 100 Chinese Pharmaceutical Industry:
Green Valley Group.
This is no ordinary shot.
On May 16th, Rao Yixian posted on his personal account, pointing directly at Green Valley’s ongoing research and developmentGV-971 lacks powerful experiments, and it is very strange that it announced in a certain media in the middle of the night of May 13 that it would stop its “international phase III clinical study”.
Rao Yi used a harsh sentence:
If there is the biggest drug fraud case in my country in the 21st century, when will you have a conscience Can a person, a responsible agency, come out to stop it?
May 17, Rao Yi once again posted a review of a past event.
In 2020, he criticized Geng Meiyu, former secretary of the Party Committee of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, for his paper on 971 Forgery, the first four authors of the paper are all from the Green Valley Group. Soon after, Geng Meiyu sued Rao Yi for reputation infringement in her own name. What is strange is that Geng Fang proposed a settlement during the first trial, showing a “guilt”. After being rejected by Rao Yi, Geng Meiyu lost the first instance. Geng Meiyu refused to accept it and continued to appeal. In the second trial, she even mentioned “reconciliation”, which was rejected by Rao Yi.
A female doctor fought a “public opinion war” with Rao Yi for many times, causing uproar, but after entering the legal process, she changed her face and said “please. And”, you might as well think about what’s the story behind it.
Rao Yi directly pierced the window paper:When will Green Valley be able to Stand up like a man instead of using a female doctor as a shield?
May 18, Rao Yi posted three times , said that it was informed that foreign 971 clinical trials had stopped, but domestic 971 clinical trials continued. There are three experiments in this experiment, two of which are:
No placebo control group.
As we all know, the so-called placebo control group is to give this group of people a harmless and ineffective fake medicine that pretends to be a medicine, and compare the test group taking the real medicine to see if the real medicine is really effective. Because people often think that the drug is effective after taking the drug, out of self-suggestion, so use this method to eliminate “psychological interference”.
What makes people wonder is that in the experiment with the control group, an insider said that the experimental party had clearly told the patient that you were taking a placebo (fake drug). ), the patient suddenly realized and reported “no effect”, in other words, the smoke bomb of “psychological comfort” was gone, resulting in a sharp drop in the value of his fourth test, in order to compare the “high curative effect” of 971 “.
If the revelation is true, it is blatant fraud.
On today (May 19), Rao Yi issued a fourth article to bombard green Gu Group “only performed 12 small mice in animal experiments (and then directly experimented with humans), most of the human experiments do not need placebo control”, 971 is not fake Where is the possibility of medicine?
Revealing Rao Yi’s anger:
“This is a crime against Chinese patients! ”
GV-971, the drug name is “Ganlutner Capsule”, is an Internet celebrity drug that claims to treat Alzheimer’s disease (senile dementia).
Alzheimer’s disease, known as the “gentle terminal disease”. Over the past decades, global pharmaceutical companies have invested hundreds of billions of dollars, The complete etiology has not been determined, and only drugs to relieve some symptoms have been developed, and there is no cure.
201910< /span>Month, an article about GV971 was jointly published by Geng Meiyu and Green Valley Group staff, which shocked the country.
It claims to be able to treat AlZheimerdisease by acting on the microorganisms in the human gut, and then affecting inflammation in the brain through them
Rao Yi, who has been engaged in molecular neurobiology research for a long time, was dumbfounded.
He said that this is equivalent to overcoming three problems at once, one is to determine that gut microbiota can affect the brain, and the other is to determine the effect of brain inflammation on AlZhai The importance of disease, the third is to treat AlZheimerdisease, and there is no Side effects. In principle, there is no single drug that can do so many things.
This is a fantasy!
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Resume shows that Geng Meiyu returned from Japan in 1997 and came to work at Ocean University of China in Qingdao.
Due to the lack of medical theory and medical practice at that time, Ocean University urgently needed a major achievement to boost the school’s reputation. As a result, Geng Meiyu, a newcomer, “invented” the magic drug 971 in the first year of her work at Ocean University.
Interestingly, from 1997 to 2019, Geng Meiyu’s related papers have always emphasized 971 acts on the nervous system of the human body; later, during the approval process of 971, the State Food and Drug Administration said that its drug molecules were too large to pass through the blood-brain barrier. So a magical thing happened. In the subsequent papers, 971 quickly changed the “direction of drug effect”, from acting on the “nervous system” of the human body, and plunged into the intestinal tract of the digestive system.
Is this a magic medicine that can play “brain teasers”?
This means that a researcher develops a drug for the first time since he engaged in scientific research, and it is the first time that a university with little relationship with medicine researches a key drug , brought a rare magic medicine into the world.
Rao Yi used a metaphor:If such a drug is real Medicine, Geng Meiyu is a genius far beyond Einstein in the field of biomedicine.
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This is a story where “legend” and “legend” collide.
In May, 2006, while facing the industry’s doubts, adhere to 971 span>Nearly ten years after “R&D”, Geng Meiyu came to the Shanghai Institute of Materia Medica, Chinese Academy of Sciences to become a researcher.
Shanghai Institute of Materia Medica is also a legendary research institution.
It has 5 academicians of the Chinese Academy of Sciences and Chinese Academy of Sciences, and more than 130 national-level high-level talents such as outstanding young people. 20During the SARS epidemic in 2003, a paper by Shanghai Institute of Materia Medica titled “Research Results of Jieeryin Lotion in Anti-SARS” shocked four audiences; 2020 During the epidemic in Wuhan in 2009, the Shanghai Institute of Materia Medica was also one of the protagonists in the research turmoil of “Shuanghuanglian”.
What I want to say is that the old director of the Shanghai Institute of Pharmacy also has a similar resume to Ms. Geng. She studied in Japan in 1992. When I returned, I worked in the Shanghai Institute of Medicine. Under its leadership, Shanghai Institute of Medicine actively invests in foreign countries on the one hand, and has a strong relationship with Green Valley Group on the other hand.
In 2000, Green Valley Group cooperated with Shanghai Institute of Medicine to establish Shanghai Green Valley Pharmaceutical Co., Ltd. Company; 2011, Shanghai Institute of Materia Medica and Zhangjiang Science and Technology invested 50 million each to establish Haihe Co., Ltd., and later changed its name to Shanghai Haihe Pharmaceutical. 5 Years later, Shanghai Institute of Pharmaceuticals transferred 19.51% of Haihe Pharmaceuticals’ equity to Green Valley Group. Subsequently, Ding Jian received 1 yuan of equity. Acquired 19.51% equity held by Green Valley Group and 20.4878% equity held by Southwest Zangjiang.
Lv Songtao, chairman of Green Valley Group, is also a “legendary”.
He opened food stalls and fried land in Zhuhai in his early years. In the 1990s, as a partner , joined the giant group in Zhuhai, and was responsible for and promoted a health product “Chinese Lingzhibao” that claimed to be “anti-cancer magic drug”.
Mr. Lu is a marketing expert. In order to win the approval for health care products, just after Valentine’s Day in 1996, Shaanxi Mingde Pharmaceutical Factory sent a “favorable fee” to Zhao Sian, the then director of the Shaanxi Provincial Health Department’s Pharmaceutical Affairs Division, and the approval was obtained the next day. At that time, the Shanghai Giant Group and the Shaanxi Mingde Pharmaceutical Factory were all headed by Lu Songtao. 5month 15, Mingde Pharmaceutical Factory once again sent Zhao Sian a “thankful fee”.
This is a great deal. Only 15,000 yuan was given to Zhao twice. This miracle drug, which has not undergone pharmacological properties, toxicological toxicity and clinical trials, was launched in such a grand manner.
In 1997, when the Giant Group had an accident, Lu Songtao decided to go it alone. He changed Shanghai Giant Group to Green Valley Group and Shaanxi Mingde Pharmaceutical Factory to Xi’an Green Valley Pharmaceutical. Then he carried the “Chinese Ganoderma Lucidum Treasure” he won, and invited various “experts” and “anti-cancer warriors” to create a “conference marketing” model all over the country. He sold the Chinese Lingzhi Bao, which cost only 0.5 yuan per gram, at the same price as gold. In less than a year, it has recorded more than 4 billion and made a lot of money.
It was later discovered that:
The so-called experts and teachers are all factory workers who graduated from nursing schools.
In 2001, the marketing myth was busted. Liu Yunyi, the prosecutor of the Tengzhou Procuratorate, sued Green Valley Pharmaceuticals in court for the tragedy of her mother’s death after taking “Chinese Lingzhibao”, and Green Valley lost the case. 2002 In 2002, under the instructions of many parties, including Chen Junsheng, the former vice chairman of the National Committee of the Chinese People’s Political Consultative Conference, the batch number of Chinese Lingzhibao was cancelled and it was withdrawn from the pharmaceutical market.
Subsequently, Zhonghua Lingzhibao changed its vest and re-launched it as “Shuangling Guben Powder”.
Chen Jinsheng, the developer of China Lingzhibao and a shareholder of Green Valley Group, wrote a paper to demonstrate its effect on liver cancer cells. The inhibition rate is as high as 93.6%, and the inhibition rate of lung cancer is as high as 100%.
Green Valley said, These experimental data are in cooperation with Professor Ding Jian from Shanghai Institute of Materia Medica obtained experimentally. Professor Ding at this time has a new identity:
Director and Vice Chairman of Green Valley Pharmaceuticals, Green Valley Research Institute long.
In addition to the resurrection of Chinese Ganoderma lucidum, with the help of Professor Ding Jian, Green Valley also obtained the approval for the traditional Chinese medicine injection of salvianolate. This traditional Chinese medicine injection later helped them make 5 billion.
The good times don’t last long.
At the end of 2006, Shuangling Guben Powder, together with the original Chinese Lingzhibao, was listed in the national “Illegal Drug Advertisement Notice” for a number of 800< /span> Yu times, created the most illegal drug advertisements in China. In 2007, the State Food and Drug Administration withdrew the approval document of Shuangling Guben San, on the grounds of reporting false experimental data, and then the industry and commerce department seized the Lugu Xi’an Pharmaceutical Factory.
In 2008, CCTV’s “Weekly Quality Report” made a special report under the title of “Expose the “Green Valley” scam. Overnight, Green Valley fell to the bottom and suffered a double blow from regulation to the market.
After the accident, Lv Songtao went to the United States and “calm” for half a year, and didn’t come back until 2009.
This time, he chose his old friend Shanghai Institute of Medicine to continue the cooperation.
2 009 is the year of double happiness for Shanghai Institute of Materia Medica.
On the one hand, the director Ding Jian was elected as an academician of the Chinese Academy of Engineering; Geng Meiyu of the Shanghai Institute of Materia Medica was awarded the National Outstanding Youth in 2007, and was selected into the “Hundred Talents Program” of the Chinese Academy of Sciences in 2008. Later, Ding Jian was also able to launch their “treasure of the town hall” – the GV-971 developed by Ms. Geng.
The conversation was very enjoyable. Lv Songtao said that he was deeply moved by Professor Geng’s confidence in his conversation.Immediately decided to spend tens of millions of dollars to fund his research:
I don’t understand the drug mechanism, but I understand you.
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Then, the legend of 971 began.
It will soon be “conditionally approved for marketing” by the State Food and Drug Administration, 2021 On 3, December , GV-971 with the drug name Ganlutner Capsule was included in the new medical insurance list again, causing an uproar on the Internet.
Sina Weibo certified by Sina Weibo as a master of neuroscience at Hokkaido University and a science popularization blogger, Zhuang Shili, questioned: “971 span>A miracle has been created, that is, when other drugs /vaccines have hot news, people often argue, and 971 has so many uproaring news for so many days, I know None of the professionals came out in solidarity with 971.”
But this does not prevent Green Valley Pharma from posting on the official website Hang the red happy news.
Green Valley said that after entering the medical insurance catalog, it will be calculated as 4 boxes per month, and the patient’s medication fee will be paid by the monthly self-pay 3580 span>yuan, down to 1184yuan. According to the national average outpatient reimbursement ratio, patients pay less than 600yuan per month. The current production capacity can meet the annual drug use of 1 million million patients.
Looking at the “Chinese Lingzhi Treasure” and “Shuangling Guben San” that were banned in the past, they have been renamed Lvgu Lingzhi Treasure and continue to be sold openly.
So magical, everything advances Get smooth sailing.
The only accident is that the 971 “broken down” recently when it went international, and it was lost on 5 In the middle of the night on 13, it suddenly announced the early termination of its international multi-center 3 clinical study.
A magical medicine that was supposed to become national pride,was a high profile Say Global Program recruiting 2046patients with mild to moderate Alzheimer’s disease, expecting2025 span>Completed clinical trials in 2018, how do you give up on giving up?
We all know that foreign clinical research is very strict and the data cannot be falsified. Surprisingly, according to media reports, according to the results of related overseas websites, the current status of the clinical trial is still displayed as:
recruiting (recruiting).
In other words, At present, there are no patients who want to participate in clinical trials?
On JD.com, I saw those buying medicines The messages from patients and their families are heartbreaking.
In the user reviews of Taobao-related drugs, a user sadly left this review:
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Set the time back to December in 2021, and Caixin released information that the first instance judgment of Geng Meiyu v. Rao Yi’s reputation infringement case was dismissed, and her “apology” and other appeals were rejected.
The most eye-catching sentence is the sentence of the court, that the judiciary should set a more relaxed environment for academic criticism:
“Encourage the truth bright”.
Yes, this should be common sense in our society.
Today, when many people are advocating “being wise and protecting one’s body”, Rao Yi shot four arrows at Green Valley Group. I even thought that if Green Valley continued to pretend Stupid, Rao Yi may still shoot the fifth and sixth arrows, until the immovable iron wall is shot through!
A contemporary Yugong shovels a hoe to the mountain. I was moved by the “naive” and “tough” of such a straightforward scholar.
What do you want to say?
There have always been two kinds of “odds” in our society.
One is that Rao Yi speaks the truth like this, never follows the trend, and only defends the truth< /strong>“Wonderful People”.
One is cheating, but “Legend of Jianghu”, which can also be delicious and spicy.
There will be more of the former “strange people”, and our society will become more and more connected Be transparent, respect the rules, and make the common sense of “what is right and what is wrong” truly indestructible common sense.
There are many more “weird people” in the latter category, and society is bound to be smoky, only talking about interests has no bottom line, and lies fly with the sickle that cuts leeks, while It has caused more and more people to distort their personalities and continue to deepen the stench of the dye vat.
Which one will make our society better and be more conducive to the safety and well-being of each of us, I think the answer is no metaphorically.
And whether they can defeat the other is not their own strength, but the majority of society votes with their feet and consciously stands on which side— —Whether be to watch the liveliness on the wall, or follow the crowd to become a part of the ocean army of “profit-seeking”; or when a warrior shouts the truth, at least Say goodbye, applaud for him, cheer for him, and don’t let them who speak out for the public become a desperate and lonely army surrounded by all sides?
I think,We can all try and be brave.
As Bei Dao wrote in “I Don’t Believe”: “I don’t believe it, Ray didn’t echo”. I don’t believe that Rao Yi shouts for justice, so the surrounding is silent, and the stone sinks into the sea; I don’t believe that despicableness becomes the pass of the despicable person, just hide the sky and cross the sea like this, and continue to indulge in the carnival of the sickle.
For this reason, “Forehead God” wrote this article.
Call on more onlookers to force the truth and the truth of the “medicine god” to come out.