Question | Does the mutation of the new coronavirus affect the detection ability of nucleic acid detection? National Health and Medical Commission Answers Cover News

The press conference of the Joint Prevention and Control Mechanism of the State Council on June 9. Photo by cover reporter Shao Meng

Cover reporter Shao Meng

On June 9, the Joint Prevention and Control Mechanism of the State Council held a press conference to introduce the work of nucleic acid testing . Do a good job of epidemic prevention and control. Li Jinming, deputy director of the National Health Commission’s Clinical Testing Center, said in response to a question from a cover reporter that the mutation of the new coronavirus has no effect on the detection ability of nucleic acid detection. Nucleic acid detection technology is also an important means of diagnosing hepatitis virus, HIV and other pathogens.

Li Jinming, deputy director of the National Health Commission’s Clinical Laboratory Center. Source: China Network

Why is nucleic acid testing the “gold standard” for diagnosing COVID-19? Li Jinming introduced that nucleic acid detection is a mature and internationally accepted laboratory diagnostic method. In the past, the detection of the pathogen of the virus mainly relied on culture, and it was identified by various methods such as staining, morphological observation, biochemical test, and immunological test. The virus was cultured for a long time, and some pathogens were difficult to cultivate in the laboratory. Later, nucleic acid detection methods were developed. The nucleic acid detection method is highly sensitive, and the specificity can reach 100% in terms of methodology. The positive result of nucleic acid test is equivalent to the result of pathogen culture and becomes the “gold standard” for diagnosis.

Li Jinming said that not only the new coronavirus, but also common pathogens, such as hepatitis B virus and HIV, can be diagnosed by nucleic acid detection methods, and treatment can be monitored at the same time.

Cover reporter questions. Source: CCTV News

The new coronavirus is constantly mutating. Is the sensitivity of nucleic acid detection affected by the virus mutation? Are the existing nucleic acid detection methods still effective?

Li Jinming pointed out that the nucleic acid detection reagent for nucleic acid detection of the new coronavirus is aimed at the double-target or triple-target genes of the new crown. Variation has little effect on the detection ability of nucleic acid testing.

“Judging from the national inter-laboratory quality evaluation results of the National Health Commission’s Clinical Laboratory Center for Delta and Omicron variant strains, as well as the practical application during epidemics across the country, the current nucleic acid testing It can be effectively detected, which also proves this.” Li Jinming said.

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