Professor Li Jun
The Fifth Medical Center of PLA General Hospital (No. 302 Hospital) )
The Fifth Voluntary Learning Center of the PLA General Hospital (302 Hospital), the former director of the Hepatology Diagnosis and Research Center of Integrative Chinese and Western Medicine, Jumei Doctor Group, Distinguished Chief Expert, Chief Physician, Doctoral Supervisor, Academic Successor of the First National Famous Old Chinese Medicine Experts.
Academic part-time job: Executive director and deputy secretary of the World Federation of Chinese Medicine Societies Association for Liver Diseases Chairman, Chang Dong, member of the Hepatobiliary Disease Professional Committee of the Chinese Association of Traditional Chinese Medicine, deputy director of the Infectious Disease Professional Committee of the Beijing Association of Integrative Medicine, member of the Standing Committee of the Liver Disease Professional Committee of the China Tunnel Medicine Education Association, academic advisor of the Liver Disease Prevention Branch of the China Society of Traditional Chinese Medicine, and a member of the Beijing Chinese Medicine Association. He is an expert of the Expert Steering Committee of the Hepatology Professional Committee of the Medical Association, an expert of the Evaluation Committee of the Science and Technology Award of the Chinese Society of Traditional Chinese Medicine, and an expert of the Science and Technology Project Evaluation of the Beijing Municipal Science and Technology Commission.
Honor:Published more than 120 academic papers, contributed or participated in editing 16 academic monographs, won the national, 10 Military Science and Technology Progress and Medical Achievement Awards. An advanced individual in Beijing’s health system and a third-class military honoree.
Q1
When can a hepatitis B patient become pregnant?
Professor Li Jun: If the liver function of the chronic hepatitis B virus carrier is normal, the e-antigen is negative, and the DNA is also negative, they can get pregnant. High level but stable liver function, you can also get pregnant, but this e-antigen is positive, especially for women of business age who have a relatively high level of hepatitis B virus DNA. Glycolic acid antiviral drugs, the use of nucleotide antiviral drugs with high pregnancy safety level, can reduce the level of hepatitis B virus to a minimum, which can reduce the vertical transmission of mother to child.
Q2
If the father has hepatitis B, will it be transmitted to the baby?
Professor Li Jun: Mother-to-child vertical transmission is an important transmission route of hepatitis B virus. If the father is chronic hepatitis B or hepatitis B virus carrier, especially the high level of e-antigen positive hepatitis B virus DNA, then there is also a chance that he will pass it on to the baby. Therefore, for newborns, hepatitis B vaccination and hepatitis B virus immunoglobulin injection should also be carried out according to the plan.
Q3
What precautions should hepatitis B patients pay attention to when pregnant?
Li Prof. Yun: Hepatitis patients are not suitable for pregnancy if the liver is in active inflammation. However, if the liver function is normal before pregnancy or in the early stage of pregnancy, and the condition is stable, it cannot be completely ruled out that the liver function fluctuates during pregnancy. Therefore, it is necessary to review liver function regularly to detect changes in liver function in time, so that measures can be taken as soon as possible. Of course, virological testing should also be carried out in time before pregnancy. If the level of hepatitis B virus DNA is high, in the middle and late pregnancy, antiviral treatment should be timely to reduce the vertical transmission rate of mother to child. There are also some pregnant women or women of childbearing age who may have already been treated with antiviral therapy before pregnancy, so we recommend continuing to use nucleotide drugs with high pregnancy safety levels to continue antiviral therapy, and at the same time, review them regularly.
Q4
What are our interventions for babies after birth?
Professor Li Jun: Hepatitis B vaccine should be given as soon as possible within 24 hours of the baby’s birth, especially within 12 hours. If the child is born to a mother with hepatitis B virus e-antigen positive and DNA positive, or a baby born to a mother with chronic hepatitis B virus, on the basis of timely and standardized hepatitis B vaccination, do not forget to receive high-titer hepatitis B immune globulin ,This is very important.
Q5
Should pregnant women stop taking antiviral drugs while breastfeeding?
Professor Li Jun: In the past, we didn’t advocate breastfeeding babies for nucleotide-based antiviral drugs, but now the latest research shows that women on antiviral therapy are breastfeeding During the period, if taking tenofovir, the child can breastfeed normally, because the content of this kind of medicine into breast milk is very low, so it can be assured.
Q6
Can chronic hepatitis B patients be vaccinated against COVID-19?
Li Prof. Jun: This is one of the most frequently asked questions by patients. In fact, we have also promoted many times, what kind of chronic hepatitis B patients can be vaccinated against the new crown vaccine. Generally speaking, First, ordinary patients with chronic hepatitis B and compensated cirrhosis, as long as their condition is stable, can safely inject the new crown vaccine. Second, hepatitis, even if chronic hepatitis is not at the stage of liver cirrhosis, liver function is in a fluctuating stage, or some complications associated with liver cirrhosis are not well controlled, the new crown vaccine is temporarily not vaccinated.
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