As of now, monkeypox cases have been reported in many countries and regions around the world, and until April 2022, human infections are rarely reported outside of endemic areas in Africa monkeypox virus, so the disease is mainly endemic. At present, the transmission route, risk index and clinical symptoms of the disease are still unclear. July 26, 2022, New England Journal of Medicine (NEJM) published the article “Monkeypox Virus Infection in Humans across 16 Countries—April –June 2022”,The research object of this study mainly includes 528 cases of infection from 16 countries in four regions of WHO (Europe, America, Western Pacific and Eastern Mediterranean), as shown in Fig. 1 shown. The results of the article indicate:98% of monkeypox virus infections occur in gay and some bisexual men, the transmission route is mainly sexual transmission, but the nine heterosexual men with monkeypox found in the study also deserve our attention. Therefore, vigilance is required when examining anyone for unusually acute rash, especially when the rash is combined with systemic symptoms, to avoid this Disease is underdiagnosed in heterosexuals. Scientists point out that in addition to sexual transmission, the virus can be transmitted through any close physical contact, respiratory droplets, and possibly through clothing and other surfaces. These results add to our understanding of how and who it spreads, which will help to rapidly identify new cases and provide preventive strategies, such as vaccination, to high-risk groups vaccine. 
Fig. 2 Penile injuryArticle in monkey pox strong>Monkeypox virus was found in semen samples, but whether semen can be transmitted to cause infection remains to be studied, as it is unclear whether the virus detected in these specimens is capable of replication, Further research needs to be done. The authors suggest that most cases of the disease are clinically mild and self-limiting, and no deaths have been noted, but this also This means that asymptomatic, milder or less symptomatic people may be missed, allowing the disease to spread. Conclusions1. This study identifies the populations most at risk of infection, which will help the world better respond to the virus. Public health interventions targeting at-risk groups help detect and slow the spread of the virus, identify disease, trace contacts and isolate scientifically will be the key measure. 2. The current international case definition needs to be expanded to add symptoms not currently included, such as oral ulcers, anal mucosa andSingle genitalsulcers. Refining the clinical symptoms will help doctors more easily identify the infection and thus prevent transmission. Given that there are currently no widely available treatments or preventive measures, rapid case identification is critical to containing the spread of the disease, prevention > remains a key measure to limit the global spread of human monkeypox infection. 3. Monkeypox is recommended in the presence of any “unusual” rash, recommended in the presence of traditional< /span>venereal disease Consider monkeypox in the diagnosis of high-risk populations with symptoms. >Anal pain or proctitis, anal or rectal swab testing should be considered.
