Longevity is the goal of everyone, and diet greatly affects our health. For example, people who like sweet are easy to gain weight, and people who like salty are prone to high blood pressure. What about people who like spicy food? Are peppers beneficial?
First of all, let’s talk about what ingredients are in peppers. There is capsaicin, the active ingredient in capsicum, the chemical name of capsaicin is trans-8-methyl-N-vanillyl-6-nonenamide, and C18H27NO3 is the active ingredient in capsicum. Capsaicin is the main reason for the spiciness in peppers. Capsaicin mainly includes dihydrocapsaicin, nordihydrocapsaicin, high dihydrocapsaicin and high capsaicin. Different degrees of capsaicin bring different pungency to humans.
span>What does capsaicin do? Capsaicin stimulates the brain to secrete endorphins, which can cause temporary pleasure.Eating chili can make people happy. Feel. This is one of the reasons why some people like to eat chili peppers. Secondly, it can stimulate the secretion of human saliva and gastric acid, and promote human digestion and absorption. “Food Materia Medica” records that pepper has the effect of warming the spleen and stomach. In addition, pepper is also rich in vitamins, which can promote the metabolism of the human body and improve the antioxidant capacity of the human body.
Studies have shown that capsaicin contained in peppers can be anti-inflammatory, anti-oxidant, and also help relieve pain, treat muscle soreness, and fight cancer. , Regulating blood sugar, eating in moderation is good for the body.
Recently, a study titled “Anti-inflammatory Effect of Capsaicin in Helicobacter pylori-Infected Gastric Epithelial Cells” demonstratedCapsaicin inhibits the release of pro-inflammatory cytokine-interleukin-8 (IL-8) from Helicobacter pylori-infected gastric epithelial cells through nuclear factor kappaB (NF-kappaB) signaling.
Cochrane, Medline, Embase and Scopus were comprehensively searched. Studies were screened up to January 16, 2020, and inclusion criteria were all observational and randomized controlled trials reporting results of interest. All-cause mortality was studied as the primary endpoint, and cardiovascular, cerebrovascular, and cancer-related deaths were studied as secondary outcomes. RESULTS: Of the 4,729 studies screened, 4 studies (including 570,762 subjects) met the inclusion criteria.
Random-effects pooled analysis showed that was associated with those who ate less or no chili peppers. In contrast, those who ate chili peppers had a 25% lower relative risk of all-cause mortality ( RR: 0.75; 95% CI: 0.64-0.88, p = 0.0004);heart Vascular disease mortality was associated with a 26% relative risk reduction (RR: 0.74; 95% CI: 0.62-0.88, p=0.0006); cancer mortality was associated with a 26% relative risk reduction.23% reduction in risk (RR: 0.77; 95% CI: 0.71-0.84, p=0.0001); no statistical difference in cerebrovascular accident (RR: 0.76; 95% CI: 95% CI : 0.36-1.60, p = 0.47).
< 4 included in the analysis In the study, there is a prospective cohort study (nearly 500,000 people in 10 different regions) from the research team of Peking University. At 7.2 years of follow-up,observed beneficial effects even if only 1 to 2 days a week, compared to those who ate spicy food less than once a week; if eating 6 Or 7 times, the risk of all-cause death was reduced by 14% and the risk of death from ischemic heart disease was reduced by 22%.
found by researchers of hematopoietic stem cells nerves are regulated. Pain-sensing nerves secrete the neurotransmitter calcitonin gene-related peptide (CGRP), which promotes the entry of hematopoietic stem cells into blood vessels. Ingestion of chili peppers triggered the activation of pain-sensing neurons and significantly enhanced the mobilization of hematopoietic stem cells in mice. Therefore, targeting the pain-sensing nervous system may be a strategy to increase the production of hematopoietic stem cells.
The study mentioned that to enhance the mobilization of hematopoietic stem cells, it may be necessary to eat 10 jalapeno peppers a day to stimulate Pain and eat for 4 days in a row. This is the hope of prolonging life for patients with leukemia and lymphoma with abnormal hematopoietic stem cells.
Coincidentally, a study found that the synthetic capsaicin analogue arvanil enhanced the active ingredient SN38 of the first-line chemotherapy drug irinotecan. Anticancer activity in human small cell lung cancer cells, arvanil-based combination therapy may be beneficial in patients with relapsed small cell lung cancer cells.
Cisplatin-based combination chemotherapy is usually the first-line treatment for patients with small cell lung cancer. Although patients initially respond well to this chemotherapy, tumors often recur within a year, and patients with relapsed SCLC are resistant to the initial treatment and have few treatment options.
When the researchers exposed two cisplatin-resistant lung cancer cell lines to low concentrations of arvanil, the cells Growth was not inhibited. However, when cells were treated with different concentrations of SN38, the active ingredient irinotecan, the presence of arvanil greatly enhanced the ability of SN38 to inhibit cancer cell growth. Statistical analysis showed that arvanil had a synergistic effect with SN38. This work will pave the way for new treatments for relapsed and cisplatin-resistant small cell lung cancer.
ps: This article is for academic sharing and communication only, not for clinical treatment suggestions, please follow the doctor’s advice!
Although chili has so many benefits, it is not advisable to eat too much chili, and chili is not for everyone! For example, people with gastrointestinal diseases, anorectal diseases, and cardiovascular and cerebrovascular diseases should eat less spicy food! Indulging in spicy food can induce many physical injuries, such as acne, constipation, sore throat, mouth ulcers, toothache, etc.
In general, eating spicy food has both advantages and disadvantages. Although there are many advantages to eating spicy food, if you do not restrain yourself or forcefully eat spicy food, will only backfire. Especially those who are unwell, be sure to follow the doctor’s advice and keep your mouth shut!
References:
1.Abstract 12729: Impact of Chilli-pepper Intake on All -cause and Cardiovascular Mortality – A SystematicReview and Meta-analysis. Circulation. 2020;142:A12729. https://www.ahajournals.org/doi/abs/10.1161/circ.142.suppl_3.12729 p>
2. Anti-inflammatory effect of capsaicin in Helicobacter pylori-infected gastric epithelial cells. 2007 Oct;12(5):510-7.doi: 10.1111/j.1523-5378.2007.00521.x .
3. China Kadoorie Biobank Collaborative Group. Consumption of spicy foods and total and cause specific mortality: population based cohort study. BMJ 2015;351:h3942< /p>
4.Nociceptive nerves regulate haematopoietic stem cellmobilization. Nature (2020). https://doi.org/10.1038/s41586-020-03057-y
5.Capsaicin analog could help treatment-resistant lung cancer. American Society for Investigative Pathology annual meeting during the virtual Experimental Biology (EB) 2021 meeting. https://www.eurekalert.org/news-releases/890581
Written｜Edited by Ann｜Little Ear
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