An elderly friend told Hua Zi that the doctor prescribed him a drug called indobufen, which was said to be anti-platelet and prevent blood clots. He asked Huazi, is indobufen and aspirin the same drug, or is it the same drug as warfarin, what is the difference between them?
Hua Zi told him that indobufen is a new antiplatelet drug. From a pharmacological point of view, it is not the same as warfarin, and is a similar drug to aspirin.
First, the similarities and differences between indobufen and aspirin
Effects: Both indobufen and aspirin are antiplatelet drugs, which can inhibit the aggregation function of platelets and can be used for the prevention of thrombotic diseases.
Pharmacological mechanism: The pharmacological mechanism of aspirin is relatively simple, only through irreversible inhibition of cyclooxygenase > The effect produces an antithrombotic effect. While indobufen has more effects, it can reversibly inhibit cyclooxygenase, and has a negative effect on adenosine diphosphate (ADP), epinephrine and platelet activating factor , collagen and arachidonic acid-induced platelet aggregation also inhibited.
Number of doses: Aspirin irreversibly inhibits platelets and is sufficient to take once a day. Indobufen reversibly inhibits platelets and requires twice-daily dosing.
Adverse Effects: Both increase the risk of bleeding. Aspirin can affect the secretion of prostaglandins in the human body, which can easily lead to digestive tract damage. While indobufen has little effect on the secretion of prostaglandins, it is less likely to cause gastrointestinal symptoms. Even if there are adverse reactions, they are very mild.
Cost-effective: Aspirin is an old drug that has been on the market for more than a century, and the daily drug price can be a few cents. Indobufen is a new drug, the price is more expensive, the daily drug price is more than ten yuan.
Application: It takes 7 days after aspirin is stopped for platelet function to fully recover, which is more suitable for daily long-term prevention of thrombosis. Platelets can return to normal 24 hours after indobufen is discontinued, making it more suitable for short-term antiplatelet therapy in patients requiring surgery.
Second, the difference between antiplatelet drugs and warfarin
Aspirin, indobufen, and warfarin all affect the body’s blood clotting function, but by different mechanisms. Among them, aspirin and indobufen are antiplatelet drugs, which inhibit the aggregation function of platelets. And warfarin is an anticoagulant drug, which inhibits the function of coagulation factors.
Anti-platelet drugs are used to prevent cerebral infarction, myocardial infarction and other diseases caused by atherosclerosis. Anti-coagulant drugs are mainly used to prevent cerebral infarction caused by atrial fibrillation, pulmonary embolism caused by lower extremity venous thrombosis and other diseases. The indications of the two types of drugs are different, can not replace each other, but can be used in combination.
Third, rational drug use to avoid excessive treatment
The benefits of drug efficacy coexist with the risks of adverse reactions, and drug therapy is recommended when the benefits outweigh the risks. Generally speaking, only people who have experienced cerebral infarction, myocardial infarction, coronary heart disease, carotid artery stenosis of more than 50%, peripheral arterial occlusive disease and other diseases need antiplatelet therapy.
People with atrial fibrillation, if they cannot be converted to a normal heart rhythm; or those who need long-term immobilization of the lower limbs (such as trauma, surgery, etc., resulting in limited movement of the lower limbs), long-term treatment is required. Anticoagulant therapy can avoid the formation of thrombus in the atrium and lower extremity veins, and prevent serious complications such as cerebral infarction and pulmonary embolism.
People without relevant indications are not advised to use the drug.
To sum up, indobufen and aspirin are similar drugs that inhibit platelet aggregation and prevent blood clots. However, there are few clinical studies on indobufen, and there is not much clinical evidence, so aspirin still occupies the main position among antiplatelet drugs. The medicine should be used under the guidance of a doctor. If you have any doubts about the medicine, please consult your doctor or pharmacist. I am Huazi, a pharmacist. Welcome to follow me and share more health knowledge.