The 39-year-old Xiao Li wanted a second child, but she still couldn’t get pregnant after trying for a long time. After seeing the doctor, she prescribed avanafil in combination with other medicines, but this medicine is I used it before married life. I wanted to know if this medicine would affect pregnancy preparations after use, so I came to consult.
Infertility is a global problem affecting couples and families, affecting approximately 15% of couples of reproductive age, and male factors account for approximately 50% of infertility. There are many factors that affect male infertility, such as endocrine abnormalities, genetic diseases, testicular and epididymal diseases, erectile dysfunction (ED), lifestyle, dietary habits, environmental factors, obesity, smoking, mental and psychological factors, etc. In the treatment of male infertility, if the patient has difficulty in erection, auxiliary drugs can be appropriately used to assist pregnancy. Xiao Li has mild erectile dysfunction (ED), so the doctor prescribed avanafil .
How common is erectile dysfunction (ED) in male infertility?
Analysis of the basic situation and ED prevalence of 896 infertile patients in two hospitals in Beijing, the age of the patients was 25-35 age. The results showed that 416 cases of male infertility suffered from ED, accounting for 46.43%, of which 246 cases were mild ED, accounting for 27.46%, showing a high incidence.
What is Avanafil?
Avanafil belongs to a class of inhibitors called phosphodiesterase type 5 (called PDE5 inhibitors) that are used to treat erections Dysfunction (ED), its mechanism of action is to restore its physiological function by relaxing the corpus cavernosum smooth muscle, filling the blood flow and restoring its physiological function, then it can be easier to conceive smoothly at this time.
In addition to avanafil, similar drugs include tadalafil, sildenafil and vardenafil. According to the individual situation of the patient, the appropriate drug is selected for adjuvant therapy.
How is avanafil different from other drugs in its class?
Avanafil is a new-generation PDE5 inhibitor, which has been improved compared to other drugs, such as adverse drug reactions From the above point of view, avanafil does not significantly increase the incidence of adverse reactions as the dose increases, and its side effects will be relatively lower. For example, the incidence of dizziness is only 0.6%, while others are more than 1%, even as high as 2.3%; the incidence of headache, vardenafil, is as high as 16%, while that of avanafil is 9.3%; There will be troublesome myalgia and back pain, and some people will still have it the next day after taking the medicine, resulting in a poor experience and some inconvenience to life.
For another example of visual abnormalities, avanafil will not appear, while the incidence of sildenafil, the first PDE5 inhibitor that came out, is 1.9%, which means that after eating Seeing is blue, so it is absolutely contraindicated in patients with retinitis pigmentosa, and visual abnormalities are more common at higher doses.
Beginning of the drug There are also differences in the effect of avanafil in 15 minutes, sildenafil in 30-60 minutes, vardenafil in 25-60 minutes, and tadalafil in 120 minutes; here I have to mention Take tadalafil, it is the only long-acting PDE5 inhibitor, the effect can last for 36 hours, it is more suitable for patients with high demand, but the above mentioned why some people still have back pain the next day after use The side effects are caused by the long-term retention of the drug in the body, and it will be fine until the drug is completely metabolized and excreted from the body.
Will Avanafil affect my baby if I take it during pregnancy?
Experiments have shown that avanafil has no effect on sperm quality and embryonic development, but it only suggests that sperm when the single dose exceeds 11 times The quality is abnormal and gradually returns to normal after 9 weeks of drug withdrawal. Therefore, it is necessary to weigh the pros and cons under the guidance of a professional doctor.
What are the precautions for taking avanafil?
1. It can only be taken once a day at most, and it is not allowed to overdose multiple times.
2. The recommended dose for the first time is 100mg. It should be taken 15 minutes in advance according to the instructions of the instructions. Drink more water to make the medicine better absorbed. The tablet should be taken whole. , do not break apart.
3. After taking the medicine, both partners should cooperate with each other to perform intimate actions, so that the medicine can exert its curative effect. It is necessary to make adequate preparations in all aspects. One point is the key. Many people do not know that sitting and waiting after eating will cause the drug to not work.
4. If the curative effect of the drug is average and cannot reach the ideal state, the dose can be appropriately increased to 200mg under the guidance of a professional doctor or pharmacist, but the single dose should not exceed this dose to avoid the risk of drug use .
5. It is forbidden to take any nitrates together with avanafil, because there is a potential pharmacodynamic interaction with avanafil. In scientific trials, avanafil can enhance the antihypertensive effect of nitrates, causing a sudden drop in blood pressure, which can lead to life-threatening hypotension. Such drugs include Xiaoxintong (isosorbide mononitrate), nitroglycerin, isosorbide nitrate tablets, etc.
Summary: Male infertility combined with ED can appropriately use drugs such as avanafil for assisted reproduction, but special attention should be paid to the use of drugs and precautions.
References:
Prevalence and related factors of erectile dysfunction in male infertility patients[J].Chinese Journal of Andrology,2020,26(11):979-983.
< p data-track="28">Preliminary study on erectile function in male infertility patients[J].Journal of Reproductive Medicine,2016,25(9):799-804.< /span>
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