Since the launch of the human papillomavirus (HPV) vaccine in 2006, the data published so far have been observed for 8 to 10 years, confirming that HPV vaccine is effective in 8 Effective for ~10 years and continuing to observe the effectiveness of the HPV vaccine. The latest report from Denmark has observed that the HPV vaccine is still effective for 12 years, and the effectiveness of the HPV vaccine is still being observed.
HPV vaccination can induce the body to produce specific antibodies. Studies have shown that the two vaccines have little difference in the prevention of HPV16, 18-related CIN (cervical intraepithelial neoplasia) 2 and CIN3, showing that the antibody response of the two is good, and the antibody titer remains stable after 9 years. s level. Pre-market immunogenicity data for bivalent and quadrivalent HPV vaccines in mainland China also showed that the antibody titers in serum reached effective immunogenicity.
Long-term follow-up studies confirmed the 10-year protective effect of the quadrivalent vaccine and showed a 12-year protective trend.
The HPV vaccine has been included in the national immunization plan in northern Europe, and a follow-up study of 8 to 10 years in adolescent girls aged 16 to 26 years, as well as the latest report in Denmark In a 12-year follow-up observation in adolescent women, no HPV16/18-related CIN2 or more severe lesions were found after quadrivalent vaccination in a population not previously infected with HPV.
A 10-year follow-up study of women aged 26 to 45 in Colombia found that only one patient with CIN 2 and 3 appeared in the 4-year basic research period, and no other patients with CIN 2 and 3 were found after that. HPV16/18-related CIN2 or more severe lesions. Therefore, the vaccines that have been marketed have a protective effect for 10 to 12 years for women who have never been infected with the vaccine type HPV.
How long the immune protection will last after the final injection of HPV vaccine is not fully understood. The reason is that the HPV vaccine has only been used in the world for more than ten years, and the protective effect of the vaccine remains to be seen.
A mathematical statistical model was used to predict the protective effect of the vaccineup to 50 years, for the final HPV vaccination can protect How many years, we need to continue to observe and summarize, and draw more meaningful conclusions from time.
Source:Human Health
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