With the continuous improvement of living standards
< /section>
People’s eating habits and diet are starting to change
This leads to a gradual increase in the number of gout patients
and the patients are getting younger
Hyperuricemia, which causes gout, has become the second largest metabolic disease in China after diabetes
It is called
the “fourth highest” after hypertension, hyperglycemia, hyperlipidemia
gout Threats to Human Health
You may not fully understand
< /p>
01
Hyperuricemia≠Gout
Although gout is caused by hyperuricemia, gout is different from hyperuricemia disease.
Hyperuricemia:According to the “Chinese Guidelines for Diagnosis and Treatment of Hyperuricemia and Gout ( 2019)” has redefined the diagnostic criteria of hyperuricemia, whether it is male or female, under normal diet conditions, blood uric acid is greater than 420 μmol/L twice on different days, which is called “hyperuricemia”.
Gout:Gout refers to that when the level of uric acid in the human body is too high for a long time, urate crystals will gradually deposit in the joints, and induce inflammation or prevent destruction, resulting in aseptic arthritis, which is characterized by redness, swelling, heat, Painful situation. Generally speaking, the first gout attack will gather in the first metatarsophalangeal joint, that is, the big toe joint. With the aggravation of gout, joints such as the dorsum of the foot, heels, ankles, knees, wrists and elbows will also be affected.
Although hyperuricemia is the root cause of gout, it does not mean that hyperuricemia Hyperemia will definitely cause gout. Some people have chronically high levels of uric acid without having a gout attack, and some people have a gout attack whose uric acid levels are not too high.
Therefore, in addition to hyperuricemia, gout attacks also require other incentives, such as high uric acid in the presence of alcoholism, overeating, cold, joint damage, etc., it is easy to attack gout. On the other hand, a gout attack can also be triggered when uric acid levels drop suddenly, such as with heavy use of uric acid-lowering drugs.
02
Why gout sufferers are getting younger change?
The middle-aged and elderly people are indeed more likely to suffer from gout than the young and middle-aged people, but in recent years, the group of gout patients has gradually become younger. According to statistics in the “2021 White Paper on Hyperuricemia and Gout Trends in China”, the overall prevalence of hyperuricemia in my country is 13.3%, of which nearly 60% are young people aged 18-35.
This is because with the continuous development of the social economy, the lifestyle of the younger generation is also changing, and some unhealthy eating habits and work and rest behaviors are unknowingly. Lay the fuse for the gout attack.
03
Common triggers for gout attacks
< /section>
Although 80% of the production of uric acid in the human body comes from the purine metabolism of its own cells, and only 20% comes from food, if Ingesting a large amount of high-purine foods at one time, such as liver, kidney and other animal offal, seafood, beef and mutton and other foods, will lead to a rapid increase in blood uric acid in a short period of time, and ethanol in alcoholic beverages will also accelerate the decomposition of purines in the body It promotes the rapid increase of blood uric acid concentration, which brings a great burden to the metabolic system of human uric acid.
< span>Current medical research believes that gout is a genetically related disease. Although the specific genetic method is still unclear, in general, gout patients with a family history of onset age earlier, more severe disease, and easier Develop tophi and gouty nephropathy.
< /section>
Regular exercise can effectively reduce the level of uric acid, but many young people do not exercise for a long time. Occasionally a vigorous and large amount of exercise will not only cause joint damage and muscle damage, but also produce lactic acid, reducing uric acid. The excretion of blood leads to an increase in the level of blood uric acid, and the increased urate is also more likely to be deposited in the injured joint, which eventually induces gout.
Excessive fatigue and disorder of work and rest will lead to a large amount of energy consumption in the body, and the accumulation of metabolic wastes will interfere with the normal metabolism and excretion mechanism of uric acid and induce gout attacks.
other than that , Gout also has the characteristics of “preference to women”. Estrogen is beneficial to the excretion and metabolism of uric acid, and premenopausal women have higher estrogen levels, so women in this age group rarely develop gout, and after women menopause, estrogen levels in the body decrease, and women suffering from gout at this time are more likely to suffer from gout. The probability is basically the same as that of men.
04
Hazards of gout to human health
Gout patients usually present with severe swelling and pain in the joint of the big toe. In addition to the toe joints, the dorsum of the foot, ankles, knee joints and other parts are also easily affected parts during gout attacks, and are relatively rare in the waist and hip joints.
The urate formed by the excessively high blood uric acid level will not only deposit in the joints, but also deposit in the blood vessels and organs to form tophi. Without active treatment and control, in advanced stage patients will not only suffer from loss of joint function, abnormal kidney function, but also many health problems such as high blood pressure, diabetes, and heart disease.
Tan Guifeng
Wenshang County People’s HospitalDepartment of Endocrinology and Metabolism Attending Physician
Good at: diabetes and its complications, growth and development, thyroid disease, pituitary, gonadal disease, hyperuricemia Diagnosis and treatment of endocrine and metabolic diseases such as
Add WeChat communication
Wenshang County People’s Hospital span>
News|Information|Disease|Medical|Services
Third-level general hospital | Second-level charging standard
< /section>
