Elevated serum creatinine may be physiological in some people

Today, the senior students taught “Oliguria and Anuria”, the evaluation of renal function, the importance of creatinine, and its relationship with urea. The reliability of nitrogen comparison, but not at all, is that:

Even if serum creatinine is elevated, it does not mean that renal function is necessarily impaired.

That is to say: some people’s increase in serum creatinine is physiological.

The reason why I didn’t talk about it is:

I’m afraid of making my classmates dizzy.

Many doctors simply believe that as long as the patient’s serum creatinine increases, it must be a kidney problem.

However, in clinical practice, especially during outpatient clinics and physical examinations, many people’s serum creatinine is higher than the baseline value, but they do not have any discomfort, and there is no obvious renal injury in repeated examinations and follow-up. As the disease progressed, some patients even had kidney biopsies without finding any lesions.

What kind of people have elevated serum creatinine in the presence of normal renal function?

Serum creatinine is primarily derived from the breakdown of phosphocreatinine in the muscle and may be excreted through the glomerulus. Men who exercise regularly, are muscular, and eat meat frequently may also experience increased serum creatinine despite normal kidney function due to the increased breakdown of creatinine phosphate in the body.