For medical professionals only
Evidence-based medicine, rational drug use
Flunarizine is a selective calcium antagonist, which can improve cerebral microcirculation and neuronal metabolism, inhibit cerebral vasospasm, platelet aggregation and increase blood viscosity [1].
What are the special uses of flunarizine for dizziness and headache? How should the dose be adjusted in elderly patients? Which groups of people need to be banned? Let’s follow Jie Xiaoyao and have a look~
How to take flunarizine? How long will it take?
Tinnitus, dizziness
Usage
Capsules, Tablets:
Idiopathic tinnitus, 10 mg, once a night, 10 days as a course of treatment[2-3].
Starting dose: 2 capsules per night may be given to patients under 65 years of age when starting treatment. If depression, extrapyramidal reactions and other serious adverse reactions occur during treatment, the drug should be discontinued in time. If there is no obvious improvement after 2 months of treatment, it can be considered that the patient does not respond to this product, and the drug can be stopped.
Maintenance treatment: If the curative effect is satisfactory and the patient needs maintenance treatment, it should be reduced to every 7 days for 5 consecutive days (same dose as above) and 2 days off . Even if preventive maintenance therapy is effective and well tolerated, it should be discontinued for observation after 6 months of treatment, and should be restarted only in the event of relapse.
The drug should be stopped promptly after symptoms are controlled, and the initial course of treatment is usually less than 2 months. If there is no improvement in symptoms after 1 month of treatment for chronic vertigo or 2 months for sudden vertigo, the patient should be considered unresponsive and the drug should be discontinued [1,4].
Migraine Prevention
Usage
Capsules, Tablets:
Migraine prevention, 5-10 mg twice daily [2-3].
Starting dose: 2 capsules per night may be given to patients under 65 years of age when starting treatment. If depression, extrapyramidal reactions and other serious adverse reactions occur during treatment, the drug should be discontinued in time. If there is no obvious improvement after 2 months of treatment, it can be considered that the patient does not respond to this product, and the drug can be stopped.
Maintenance treatment: If the curative effect is satisfactory and the patient needs maintenance treatment, it should be reduced to every 7 days for 5 consecutive days (same dose as above) and 2 days off . Even if preventive maintenance therapy is effective and well tolerated, it should be discontinued for observation after 6 months of treatment, and should be restarted only in the event of relapse [1,4].
How do I adjust the dose in elderly patients?
Initial dose: 5mg per night in patients over 65 years of age. If depression, extrapyramidal reactions and other serious adverse reactions occur during treatment, the drug should be discontinued in time. If there is no significant improvement after 2 months of treatment, it can be considered that the patient does not respond to this product, and the drug can be stopped.
Maintenance treatment: If the curative effect is satisfactory and the patient needs maintenance treatment, it should be reduced to every 7 days for 5 consecutive days (same dose as above) and 2 days off . Even if preventive maintenance therapy is effective and well tolerated, it should be discontinued for observation after 6 months of treatment, and should be restarted only in the event of relapse [1,4,5].
Because the nervous system of elderly patients is more sensitive and the metabolic capacity is weak, it should be used with caution, and the dose should be reduced as appropriate[1-5].
Category 3 is prohibited
Contraindicated in acute cerebral hemorrhage.
This product is contraindicated in patients with a history of depression, Parkinson’s disease, or other extrapyramidal disorders symptomatic patients.
Contraindicated in patients allergic to flunarizine or any of its excipients [1-4,6].
More Corey’s popular drugs, where to learn?
You just entered the department, where do you want to master the commonly used drugs in the department? In what situations does the dosage need to be adjusted? Do you want to double it for the first use? Whether the solvent is prepared with salt or sugar…
As a veteran of Corey, what is the difference between injections and tablets? What foreign usage can be used for reference? How to deal with drug overdose calmly? In the face of newcomers, how to elegantly throw a link to let Xiaobai learn the knowledge of medicine?
Dry food you want
Doctor’s Station”Evidence-Based Medication” columns all have