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A new study showed that choroid plexus volume and permeability correlated with the severity of cognitive impairment on brain MRI.
< /p>News from the Radiological Society of North America on May 17
According to recently published in ” A new study in the journal Radiology shows that increased volume of a vital structure in the brain called the Choroid Plexus> is associated with greater cognitive impairment and greater cognitive impairment. Alzheimer’s disease.
Research published in “Radiology” on May 17, 2022 (latest impact factor: 11.10
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The choroid plexus is a network of blood vessels, connective tissue, and cells that reside in brain spaces called ventricles. The choroid plexus plays an important role in brain health. It is the passage of immune cells from the blood to the brain. As the primary site for the production of cerebrospinal fluid, it is critical for removing waste and toxic proteins from brain cells. This role is particularly important in Alzheimer’s disease. Recent studies have shown that disease progression is associated with the accumulation of abnormal proteins called amyloid and tau and subsequent neurodegeneration.
“Researchers believe that impaired clearance of abnormal amyloid and tau, not overproduction is responsible for Alzheimer’s disease ,” said the study’s senior author Won-Jin Moon, MD, professor of radiology and chair of the department of radiology at Konkuk University School of Medicine in Seoul, South Korea, “so we hypothesized that the abnormal state of the choroid plexus is related to the failure of clearance. Associated with accumulation of waste and toxic proteins in the brain and neuroinflammation due to failure of immune surveillance.”
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Little is known about the imaging features of the choroid plexus in cognitive impairment.
To learn more, Dr. Moon and colleagues performed brain magnetic resonance imaging on 532 participants at various stages of cognitive impairment imaging. Of the 532 participants, 132 underwent permeability imaging using dynamic contrast-enhanced MRI.
Choroid plexus volume and permeability are associated with severity of cognitive impairment on brain MRI. The choroid plexus volume is larger in dementia patients with Alzheimer’s disease than in non-demented patients. Higher choroid plexus volume was negatively correlated with memory. It also negatively affects executive function, a set of mental skills that govern things like self-control and planning.
“Our study found that enlarged choroid plexus volume was independently associated with increased cognitive impairment,” said Dr. Moon. strong>There was no relationship between choroid plexus volume and amyloid pathology, but there was a significant relationship between choroid plexus volume and the severity of cognitive impairment.”
< img class="content_title" height="300" layout="responsive" sizes="(min-width: 320px) 320px, 100vw" src="https://mmbiz.qpic.cn/mmbiz_png/tCafVcBJEEaE1XK6W7qc6B0oic6DiahANiczY2tUAS8sqNBSibiatVEwZ8wh2sr1NaWopgTuK9B243OwtIKZopgTuK9B2ibAgwwidth" ="600">Comparison of choroid plexus (CP) volume (red) from four representative 3.0-T brain MRI scans according to disease stage on the cognitive impairment spectrum. Patients with Alzheimer’s disease (AD) have greater CP volume than patients with subjective cognitive impairment (SCI) or mild cognitive impairment (MCI). All patients were 75-year-old women
The findings point to new possibilities for the role of MRI in the diagnosis of Alzheimer’s disease.
“I think our findings on the choroid plexus suggest that it can serve as a new potential M for clearing damaged systems and neuroinflammation.RI imaging alternatives,” said Dr. Moon.
Other potential clinical applications include helping researchers develop new targeted drugs or treatments to clear failures and neuroinflammation Ultimately, choroid plexus measurements can help speed treatment for those most in need.
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“If we combine choroid plexus volume and hippocampal volume during the screening phase, it may help us better distinguish more vulnerable patients from less vulnerable patients patients,” said Dr. Moon.
The researchers plan to follow up with a longitudinal study. As the disease progresses, they will explore how the choroid plexus volume changes over time. Change.
Founded in 1931, Konkuk University
References
Source: Radiological Society of North America< /p>
Choroid plexus volume linked to Alzheimer’s disease
Reference:
Choi JD, Moon Y, Kim HJ, Yim Y, Lee S, Moon WJ. Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum. Radiology. 2022 May 17:212400. doi: 10.1148/radiol.212400. Epub ahead of print. PMID: 35579521.
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