Choosing “phosphorus” to live in a better situation | Fos propofol disodium for injection is closer to the ideal drug for induction of anesthesia

>Induction of anesthesia refers to the reversible process in which a patient goes from a awake state to a state where surgery can be performed under the action of drugs. It is the most risky stage in the process of general anesthesia. It is vividly likened to the takeoff of an airplane ^[1].

With the development of medicine and technology, clinical practice constantly puts forward new requirements for an ideal induction of general anesthesia, that is, to achieve an ideal induction of general anesthesia. Status: Simple medication without adverse reactions, stable hemodynamics, smooth breathing, stable internal environment, stable vital signs, good anterograde amnesia, complete pain relief, muscle relaxation, stable endocrine response, which is conducive to the maintenance of anesthesia ^[2].

As early as 1934, the use of sodium thiopental in clinical anesthesia marked the beginning of modern intravenous anesthesia^[3]. Propofol, which came out in 1973, has some characteristics of an ideal sedative drug, and once became the most widely used anesthesia inducer^[4]. However, the clinical application of propofol over the years has also exposed some limitations of propofol itself and its use as an emulsion: injection pain, hyperlipidemia, severe allergic reactions, risk of bacterial contamination, etc.^[5]. In order to meet the clinical needs that propofol could not achieve, fospropofol disodium came into being.

Fospropofol disodium, closer to ideal intravenous anesthetic

Fospropofol disodium for injection (fosprofen ^®) was jointly developed by Yichang Renfu Pharmaceutical and West China Hospital of Sichuan University. It is a new class 1 chemical drug and is the first water-soluble Poofol prodrug is also one of the most advanced general intravenous anesthetics in domestic research.

As a prodrug of propofol, fospropofol disodium is a “soft GABAA receptor agonist”, which can more It can control the state of anesthesia well, so it is close to the ideal sedative and anesthetics^[4]. Pre-marketing clinical studies have shown that the use of fospropofol disodium during anesthesia induction has good sedative effect and high safety, especially in improving injection pain and reducing drug addition, which is significantly better than propofol, which is more effective than propofol. Ideal intravenous anesthetic.

← Fospropofol disodium

Propofol→