Calorie restriction simulants may avoid ineffective fasting and prolong life efficiently
Keywords: fasting, healthy lifespan, simulated fasting
talk To the scientific study of the intersection of fasting and longevity, “The Longevity Diet” by Dr. Walter Longo, director of the USC Longevity Institute, has become an international bestseller. Research using fasting to improve health and prevent disease was named one of the 50 Most Influential People of 2018 by Time Magazine.
Dr. Longo and his team have conducted years of research to develop a diet that mimics fasting, showing convincing results in multi-system regeneration, enhanced cognition and healthy longevity.
Many people can realize that if fasting is too long, the body’s metabolism will actually slow down, but if fasting is not long enough, it will not go into ketogenic mode, so it must be fasted correctly to benefit from. So many of the fasting participants right now seem to be just participants and don’t really reap the health benefits. Dr. Longo also talked about intermittent fasting, arguing that the current data supports fasting for 12 hours a day, but not the popular 16-hour fast.
In addition, calorie restriction simulants, such as spermidine, rapamycin, metformin, etc., have been developed in the field of fasting. Taking spermidine as an example, the content of this substance in the body will change with There is a gradual decline with age, and although supplementation with a varied diet rich in spermidine is generally beneficial, the most effective approach is to take a spermidine supplement, which is naturally occurring, highly effective, and has low toxicity. Long-term supplementation can produce similar Beneficial effects of caloric restriction. Spermidine supplements are generally anti-aging. Although not a panacea, their overall health benefits have been proven in many fields of research.
While fasting has the potential to provide longevity benefits, it is still a practice that requires careful consideration and caution. For now, the simulated fasting approach might be worth a try.
[References]
1. Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S. et al. The positive effect of spermidine in older adults suffering from dementia. Wien Klin Wochenschr 133, 484–491 (2021).
2. Kumsta C, Chang JT, Lee R, et al. The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Nat Commun. 2019 Dec 11;10(1):5648. doi: 10.1038/s41467-019-13540-4. PMID: 31827090; PMCID: PMC6906454.