“1+1” injection method: firstly inject 1mg of hydromorphone, 15min later to assess the pain of the patient, if the pain is not well controlled, add another 1mg .
The study showed that patients with acute pain in the emergency department were treated with two analgesic regimens of hydromorphone: (1) a one-time injection of 2 mg of hydromorphone; ② “1+1” injection method. It was found by comparison that the two regimens had the same safety and efficacy, but the latter could achieve a more satisfactory analgesic effect. For acute severe pain patients in the emergency department, the use of a “1+1” analgesic regimen within the first hour may be prioritized.
Instructions for Use of Hydromorphone Prefill[2] sup>
The instructions for use are derived from Hydromorphone Hydrochloride Injection The (pre-filled) instructions are for reference only by clinicians. For detailed usage, please refer to the instructions.
References
< >[1]Chang AK, Bijur PE, Lupow JB, Gallagher EJ. Randomized clinical trial of the 2 mg hydromorphone bolus protocol versus the “1+1” hydromorphone titration protocol in treatment of acute, severe pain in the first hour of emergency department presentation. Ann Emerg Med. 2013;62(4):304-310.
[2]Instructions for Hydromorphone Hydrochloride Injection (Prefilled Syringe Package) p>
(Yichang Renfu Pharmaceutical Marketing Department)
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