A buddy with high blood pressure complained to Hua Zi that he was taking nifedipine sustained-release tablets. The high pressure can be controlled, but the low pressure is too difficult to drop. He asked Hua Zi, what medicine can control the low pressure? Huazi told him that all antihypertensive drugs are used to lower high pressure and low pressure together, and there is no single drug to control low pressure.
However, from a pharmacological point of view, elevated low pressure can be tried with a sartan drug, but the drug should be adjusted under the guidance of a doctor.
One, low pressure is produced by the aortic system
Blood discharged from the heart during systole first enters the large arteries, and then gradually flows to the small arteries and capillaries. However, the blood discharged from the heart cannot flow into the small blood vessels all at once, so it can only be stored by the expansion of the large arteries. When the heart dilates, the large arteries elastically recoil, pushing blood to the peripheral arterioles.
That is, the aortic system acts like a “balloon” that puts pressure on the blood as it retracts. The lowest value of this pressure is the diastolic pressure, commonly known as the low pressure.
There are two main factors that affect low pressure, one factor is the elasticity of the aorta, the greater the elasticity (this is a good thing), the higher the low pressure; also One factor is the resistance of the peripheral arteries, the greater the resistance, the higher the low pressure.
Second, increased peripheral arterial resistance is the main reason
In people with elevated low pressure, it is primarily due to increased peripheral arterial resistance. A common factor is increased sympathetic tone, leading to increased release of epinephrine and norepinephrine, resulting in peripheral arterial constriction.
There are many reasons for increased sympathetic tone, such as excessive work and life pressure; or long-term anxiety, depression, tension, and fear; or obesity , lack of exercise; or irregular work and rest, often staying up late, etc., are common factors.
The elasticity of the great arteries in the young population is normal, so the common feature of hypertension is normal high pressure, but simply elevated low pressure.
Three, sartans can be used to control low pressure
Sartans are first-line antihypertensive drugs and are pharmacologically classified as angiotensin 2 receptor (AT receptor) blockers. The mechanism of action is to block the angiotensin 2 receptors on the blood vessels to avoid binding with angiotensin 2, thereby producing the effect of dilating blood vessels (effective on arteries and veins) and lowering blood pressure .
Sartans can also block AT receptors on the presynaptic membrane, reducing the release of norepinephrine, reducing sympathetic tone and restoring Sensitivity of the carotid sinuses (baroreceptors) can also contribute to a reduction in blood pressure.
So sartans have a better control effect on low pressure.
Fourth, most people need a combination of drugs
Many people have reported to Huazi that when treating high blood pressure, taking only one drug is not effective, and increasing the dose will increase adverse reactions. Therefore, about 70% of hypertensive patients need to use two or more antihypertensive drugs to form a combined drug regimen in order to control their blood pressure.
Sartans are often used in combination with dipines, which not only increases the effect of blood pressure control, but also reduces the side effects of lower extremity edema caused by dipines.
If the heart rate exceeds 80 while the low pressure rises, lorols can also be used to lower the heart rate while controlling the blood pressure. It is also possible to combine dolols with dipines.
To sum up, from the perspective of pharmacological mechanism, sartans have better effect on low pressure control. But blood pressure should not only rely on drugs. Along with medication, a healthy diet with low salt, low fat, and low sugar should be taken, and weight loss, increased exercise, and reduced emotional stress should be taken. The medicine should be used under the guidance of a doctor. If you have any doubts about the medicine, please consult your doctor or pharmacist. I am Huazi, a pharmacist. Welcome to follow me and share more health knowledge.