Everyone must be familiar with AIDS.
As for the research of AIDS, medical experts and scientific research staff have never given up to stop the exploration of AIDS.
Ahead of the 24th International AIDS Conference (AIDS 2022) on July 29 in Montreal, Canada.
Recently, the City of Hope research team in the United States announced that a 66-year-old HIV-infected patient was cured , the patient was diagnosed in 1988, later developed leukemia, and received a bone marrow transplant in 2019.
Following, the patient got remission of leukemia and HIV after transplantation, and in the follow-up observation No sign of HIV replication was found, making it the fourth AIDS cure in the world.
And all of this is mainly due to the fact that the bone marrow donor has a rare genetic mutation – the deletion of the CCR5 gene— —CCR5del32 encoding gene.
After transplantation of hematopoietic stem cells with CCR5 gene mutation, the HIV virus cannot replicate in the body, thus gradually eliminating HIV and achieving HIV cure.
What is CCRdel32?
Chemokine receptor CCR5 is an on-cellular receptor for HIV-1 virus to invade human immune leukocytes.
In the gene encoding CCR5, If the 32bp gene is deleted, the newly generated immune cells will lack the CCR5 receptor, and the natural HIV virus will not be able to infect the immune leukocytes generated in the patient .
This means that during the treatment of leukemia, the patient first killed cancer cells through chemotherapy, and then transplanted hematopoietic stem cells with CCR5 gene mutation to achieve long-term remission of AIDS, and even cure.
Compared with previously cured AIDS patients, this patient is the oldest patient who has been cured of AIDS so far, and is expected to provide new hope for elderly AIDS patients and cancer patients.
How long can someone with AIDS live without treatment?
Most people know that AIDS is often not directly lethal. The most critical reason for AIDS to cause death is that HIV infection attacks the body’s immune system, which will eventually completely destroy the human body. immune system.
At this time, it may only take a common fever and a cold, which is very likely to endanger the patient’s life.
AIDS has a very long incubation period, that is, the period of illness without obvious symptoms, which varies from 2 to 20 years. Physical condition will deteriorate sharply.
In the process of deterioration, the immune cells in the human body will be violently attacked, and the immune system of the human body will be useless. Died inside.
Can AIDS be cured?
Although AIDS has a very high mortality rate, it does not mean that if a patient has AIDS, he should give up treatment and wait for death.
According to today’s medical conditions, AIDS can achieve ideal effects through treatment, but the current treatment methods cannot immediately resist the spread of HIV infection in the human body.
Current methods are usually by minimizing the amount of virus in the patient’s body and trying to restore the human immune function of AIDS patients, through this method to increase the lifespan of patients , Reduce the various complications caused by AIDS in patients.
AIDS treatment, the sooner the better
Once a patient is tested positive for HIV, they need to go to a regular hospital to complete the corresponding treatment. Only by cooperating with the treatment can the risk of death of the patient be minimized and the impact of AIDS be minimized.
AIDS treatment is a tough challengeDuring the war, the patient must adhere to the treatment, and the treatment cannot be interrupted in the middle of the treatment. Usually, it is necessary to insist on taking the medicine, and it is also necessary to go to the hospital for review on time.
Generally, after 3-6 months of treatment, the patient’s immune ability can gradually recover.
When taking medicine, sometimes there will be various adverse reactions, and the patient will think that taking the medicine will aggravate their own disease. At this moment, the patient cannot stop the medicine at will, and needs to go to the hospital for review, according to the doctor’s suggestion , adjust the usual medication regimen.
In addition, in order to ensure the actual effect of the treatment, the patient needs to take the correct treatment according to the doctor’s advice, and it is recommended to use effective and efficient medicines when taking the medicine. secondary.
Can AIDS patients be cured?
The medical standard to define AIDS recovery is that the patient’s AIDS-related symptoms basically disappear, and the patient’s condition does not continue to deteriorate.
It can be seen that the recovery of AIDS patients does not mean that the patient’s AIDS will be “completely cured”, and this kind of cure does not mean that the “cured patient” will not relapse completely, nor does it mean that there will be no recurrence of AIDS. infect others.
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