I took antipyretics for a cold, but my kidneys failed. The doctor reminded me: Be sure to take medicines as prescribed by the doctor

內容目錄

Source: The Second Hospital of Zhejiang University

Recently, the Department of Nephrology of the Second Hospital of Zhejiang University admitted a 65-year-old male patient. The patient from other places had a severe stomach bloating, but the urine output decreased after the onset. Gradually decreased, and after 3 months of treatment in the local township, prefecture, and provincial capital hospitals, the effect was not good, and the last drop of urine was gone. The patient and his family did not give up and were transferred to the Second Hospital of Zhejiang University.

The examination found that the serum creatinine exploded to 1718 (normal reference value <132). After understanding the condition, the initial diagnosis was acute renal failure.

Ma Kunling, director of the Department of Nephrology of the Second Hospital of Zhejiang University, carefully reviewed the medical records of other hospitals. All the causes of acute renal failure were basically found in the examination, and no problems were found. The emergency blood routine and B-ultrasound examination at the Second Hospital of Zhejiang University were normal. Dr. Ma Kunling decided to perform a renal puncture examination for the patient.

Because the patient’s serum creatinine is very high, there is a certain risk of renal biopsy. After fully understanding the condition, Ma Kunling decided to give daily dialysis until the serum creatinine dropped to about 200, and then kidney biopsy was performed. . The results showed that the renal tubules showed moderate-severe pathological changes. The tubular epithelial cells had vacuolar degeneration, shedding, necrosis, renal interstitial edema and inflammatory cell infiltration.

Kidney biopsy pathology ( Light microscope and electron microscope)

The reason is self-administration of antipyretics

It is obvious that this is acute renal failure caused by acute tubular necrosis, and it is most likely related to drugs. Repeatedly asking the patient about the medical history, we made an unexpected discovery – 3 months ago, the uncle took the antipyretic acetaminophen because of a “cold”. After taking it for 1 week, he developed anorexia and abdominal distension, but he didn’t care at that time. After the symptoms gradually increased, and chest tightness, shortness of breath, oliguria, to the local hospital for treatment.

The pathological damage to the kidneys was clarified. Since there was no major problem with the glomerulus, Dr. Ma Kunling judged that the kidneys might be saved. On the basis of maintaining hemodialysis, the nephrology team of Zhejiang University Second Hospital gave glucocorticoid therapy. After a period of hospitalization, the patient’s urine output finally increased, and soon a polyuria phase occurred, and he was removed from hemodialysis treatment. Two months later, when I came to my clinic for a re-examination, my serum creatinine had dropped to about 100, and other indicators had basically returned to normal. This case has always been fresh in my memory. I did not expect the kidneys to recover after suffering an extreme blow. Although the condition was tortuous, the outcome was beautiful and the patient was lucky.

Be sure to take medicines as prescribed by the doctor

Dr. I have encountered many in clinical work. For example, acute renal failure occurs after taking liver-protecting health products; acute renal failure occurs due to improper use of traditional Chinese medicine, antipyretic analgesics, antibiotics and other drugs, and so on. Such things can be said to be bloody lessons.

Here to remind everyone! ! ! In the absence of professional medical guidance, it must be used with caution.

Most of the drugs are metabolized by the kidneys, and the drug concentration further accumulates after reaching the renal tubules. There are many drugs with certain nephrotoxicity, which can induce acute interstitial nephritis and acute tubular necrosis. In addition, the use of traditional Chinese medicine or decoction of Chinese herbal medicine, remedies, etc. must be taken under the guidance of professional doctors. Acute renal failure induced by the use of traditional Chinese medicine is very common.

How to self-assess renal function

Changes in urine output: The daily urine output of healthy people is generally between 1000ml-2500ml, which varies due to changes in water intake. If the urine volume is less than 400ml, it is medically called oliguria, and less than 100ml is called anuria. If the urine does not increase significantly after increasing the water intake, or continues to be oliguria or anuria, you should be vigilant at this time. the possibility of acute renal failure.

Observe the accompanying symptoms: With the progression of acute renal failure, patients often have some accompanying symptoms, such as swelling of the lower limbs and eyelids, fatigue, anorexia, nausea, chest tightness, palpitation, dizziness, increased blood pressure , chest tightness at night often has to sit up, etc. The above changes may be related to the rapid progression of acute renal failure.

Pay attention to the results of physical examination and test: a simple examination can quickly help clarify renal function, blood routine, urine routine, renal function electrolytes, urinary B-ultrasound, do these tests, it will be clear soon .

Review: Xinya

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