Many parents of myopic children
should have heard of itlow-concentration atropine
is the “star product” in the parent group
and recently, Xingqi eyes A wholly-owned subsidiary of the company
Shenyang Xingqi Eye Hospital issued an announcement saying that
↓
Since July 22, Internet hospitals have suspended the prescription of 0.01% atropine sulfate eye drops in hospital preparations, and patients can go to physical hospitals to issue a prescription if necessary.
This announcement confirms the news that the low-concentration atropine nosocomial preparations that have been widely circulated are about to stop being sold on the Internet .
A number of experts said, In-hospital preparations may have a certain degree of side effects due to the relatively simple approval process , such personalized medicines are not suitable for Internet sales.
According to media reports, after the news came out, many parents of myopic children began to stock up. , scalpers have also taken action, and the price of atropine eye drops in Shanghai Orthopaedic Hospital has soared nearly 6 times.
low< span>Concentration atropine
Not yet approved but “bypassing” Internet sales span>
Many companies want to follow the “Xingqi Model”
< span>Southwest Securities Research Report pointed out that
a 5-year overseas study in 2016,
400 subjects were enrolled The clinical study of the patients in the study
confirmed that low-concentration atropine (0.01%)
delayed the treatment of myopia in children and adolescents
Notable safety and efficacy
The clinical research results were published in
the international authoritative ophthalmology journal “Ophthalmology”
and many domestic A clinical study also came to the same conclusion
Because of this, atropine is widely used in the market
Also received the title of “magic medicine” for myopia
In October 2021, the “Guidelines for Appropriate Technical Guidelines for the Prevention and Control of Myopia in Children and Adolescents (Updated Edition)” (referred to as the “Guidelines”) issued by the National Health and Health Commission pointed out that myopia children and adolescents should use low-concentration atropine or wear corneal plastic surgery. When the OK mirror slows down the progression of myopia, it is recommended to go to a regular medical institution, under the guidance of a doctor, according to the medical instruct to proceed.
It is understood that relevant medical institutions and listed companies have deployed “low-concentration atropine”. According to the National Drug Clinical Trial Registration and Information Publicity Platform, there are currently 8 clinical trials on “atropine sulfate eye drops” in progress, and most of its indications are “delaying the progression of myopia in children”.
However, so far
not yet available in China
FDA Approved Atropine Eye Drops
p>
Xingqi ophthalmic drug, as the company with the fastest clinical research progress of atropine eye drops in China, its phase 3 clinical trial is still in progress. However, Xingqi ophthalmic medicine did not wait for the approval of atropine eye drops, but chose to let atropine eye drops be marketed in the form of in-hospital preparations.
In January 2019, the atropine sulfate eye drops declared by Shenyang Xingqi Eye Hospital were approved by Liaoning Provincial Drug Administration The “Medical Institution Preparation Registration Approval” issued by the Administration. Patients only need to upload prescriptions, medical records and other materials, and then they can purchase atropine eye drops on the Internet hospital platform of Shenyang Xingqi Eye Hospital, realizing remote purchase of drugs. Therefore, atropine eye drops as an in-hospital preparation have achieved heavy doses nationwide in advance.
With the blessing of atropine eye drops, the performance of Shenyang Xingqi Eye Hospital has increased year by year. Xingqi Eye Medicine disclosed in its reply letter to the Shenzhen Stock Exchange in October 2021 that from January to July in 2019, 2020 and 2021, the drug revenue of Shenyang Xingqi Eye Hospital was 14.01 million yuan, 114 million yuan and 142 million yuan respectively. Yuan, accounting for 59.17%, 83.01%, and 88.67% of the hospital’s revenue, respectively, and atropine eye drops are the main source of the hospital’s drug revenue.
behind Xingqi Eyedrops
There are many imitators
such as OPCOM As announced in early June, its subsidiary Hefei Kangshi Eye Hospital has obtained the approval for the registration of medical institutions, and can begin to formulate and sell low-concentration atropine for the prevention and control of myopia in children and adolescents.
Opcon Vision said in an interview with the media that atropine eye drops are normally sold in the hospital, but the Internet Treatment has been suspended.
Parents rush to stock up
Cattle Sitting From
With Atropine Drops
< p>The news of the suspension of online sales comes out
Many myopic children haveParents
expressed on social platforms
“ Urgently need to stock up”
The price of a single box of Xingqi eye drops is 298 yuan, a box of 30 sticks (0.3ml/ sticks), can be used for one month. However, not all parents of children are able to stock up successfully. Parents’ “stocking anxiety” has also given the “scalpers” an opportunity.
A parent, Ms. Zhang, told reporters, “Last night, I kept swiping the applet and didn’t get into it. I saw that there are errands to buy, and the errands cost 100 yuan.”
On the Xianyu platform, there are already The “running errands” who claimed to be able to buy Xingqi ophthalmic drug atropine eye drops on their behalf cost 100 yuan. However, a purchasing agent added to the reporter that if you really need to buy more, the price of a box needs to be increased by 20 yuan.
A low-grade patient from the Eye and Ear, Nose and Throat Hospital Affiliated to Fudan University in Shanghai (also known as “Shanghai Otaryngology Hospital”) Concentration atropine eye drops, the specification is 5ml/piece, there are scalpers priced at 33 yuan/piece (offline transaction, excluding postage), and there are also scalpers with quotations as high as 180 yuan/piece (including free shipping) and 220 yuan/piece (including Free shipping, Shanghai local 200 yuan / piece).
The Atropine Eye Drops from Shanghai Orthopaedic Hospital can be used for one month each with a shelf life of 30 to 40 days. Some parents of children revealed on Zhihu that the daily price of the product is 32 yuan per piece, plus a registration fee of 25 yuan, which needs to be refrigerated and stored, and the hospital does not support mailing.
According to this calculation
Under scalper reselling
Shanghai Ophthalmology Hospital Atropine Eye Drops
The price of each bottle has skyrocketed nearly 6 times
Regarding the transportation and storage of preparations in the hospital, Zhang Xusheng, a toxicologist at the Chinese Society of Toxicology, pointed out that because scalpers are not professionals in the pharmaceutical industry, although the purpose of controlling the temperature and maintaining the efficacy of the medicine is achieved by placing ice packs, But how to ensure the formulation is always in the right state during transportation is out of the scalper’s control.
“It is difficult to ensure that the transportation of the preparation meets the corresponding specifications by only ordinary express delivery, and at the same time it violates the The principle of limited circulation of in-hospital preparations.”
In-hospital preparations are not suitable for Internet sales
Supervision should be strengthened in the future
According to Article 24 of the “Implementation Regulations of the Drug Administration Law of the People’s Republic of China”, preparations prepared by medical institutions shall not be used in For sale on the market or in disguised form, no advertisements for preparations of medical institutions shall be published.
Industry insiders of ophthalmic medical institutions said that a number of Internet eye hospitals have recently stopped selling atropine drops Eye drops can only be prescribed offline in physical hospitals. This suspension of sales is subject to relevant national policy requirements and does not involve the quality of the product itself.
Senior Partner, Beijing Jundu Shanghai Law Firm,
Zhang Wenbo said in an interview with reporters:
Drugs that are too personalized are not suitable for Internet sales, which is equivalent to infinitely magnifying the hidden dangers of drug safety. Based on the first consideration of patients’ interests, the suspension of Internet sales is conducive to the premise of safe medication for patients and reduces systemic risks.
Zhang Wenbo said that the current online sales of in-hospital preparations are still in a gray area, and there is no certainty. To implement strong supervision, it is necessary to clarify the legality of the sales of in-hospital preparations in Internet hospitals from the policy level or the legal level.
Source: Health Times, Times Finance, Daily Economic News, Shanghai News Broadcasting p>
Editor: Hong Meijuan