On July 24, 2022, hosted by China Pharmaceutical Enterprise Management Association and China Children’s Drug Research and Development and Industrialization Alliance (hereinafter referred to as “Pediatric Drug Alliance”), Beijing Children’s Hospital Affiliated to Capital Medical University, National Children’s Medical Center Co-organized with China Pharmaceutical Industry Information Center and supported by Jiangsu Kangyuan Pharmaceutical Co., Ltd., a symposium on innovation and clinical application of traditional Chinese medicine preparations for children was successfully held. 20,000 people in the industry who are concerned about children’s medicines attended the conference simultaneously through online live broadcast.
Traditional Chinese medicine is a unique medical and health resource in our country, with huge cultural energy and economic potential . Children’s traditional Chinese medicine preparations are also an important part of pediatric clinical medicine. In order to better promote the innovation and clinical application of traditional Chinese medicine preparations for children, the meeting invited representatives of medical institutions, pharmaceutical R&D and production enterprises, scientific research institutes, parents and other groups to discuss the current situation and challenges of traditional Chinese medicine preparations for children.
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my country’s effective prevention and control of the new crown epidemic is recognized worldwide, and traditional Chinese medicine has played a unique role. In children’s health protection, traditional Chinese medicine is still indispensable! Facing the entire industry chain, the Hope Alliance focuses on solving common key technologies that are stuck in the neck, raises the sails of health for children, and continuously launches good medicines and new medicines, so that hundreds of millions of children can continue to enhance their sense of gain, happiness and security! The alliance has been established for nearly two years, and its achievements are obvious to all, and its influence in the industry has gradually expanded. It is expected that the alliance will give full play to the role of the communication platform, promote consensus among government departments, and form policy synergy; give full play to the role of the information platform, accelerate the construction and improvement of the database, effectively connect clinical needs with R&D and production, and bring information sharing to a new level. Strengthen international comparative analysis, learn from each other’s strengths and complement each other’s weaknesses, and continuously improve the global competitiveness and influence of my country’s children’s medicine!
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The material basis for the clinical efficacy of traditional Chinese medicine – the unclear group of functional components is the key problem to be solved urgently in the research of traditional Chinese medicine. The group is the core to enhance the connotation of Chinese patent medicine. Through the construction of research platforms such as the discovery, screening and evaluation of innovative Chinese medicines, quality control of the whole production process, formulation technology, and intelligent manufacturing technology, we will overcome the identification technology of functional components of traditional Chinese medicine, the large-scale preparation technology of traditional Chinese medicine components/ingredients, the “high-throughput- “High-content” verification focus technology and traditional Chinese medicine efficacy component dose-response range evaluation technology will help the high-quality development of the traditional Chinese medicine industry and contribute to the construction of a healthy China.
Thanks to the National Health and Health Commission, the Ministry of Industry and Information Technology and the Food and Drug Administration for their care and support for the work of the Pediatric Drug Alliance. Traditional Chinese medicine is an important part of the excellent culture of the Chinese nation and plays an important role in the treatment of pediatric respiratory, digestive, common and frequently-occurring diseases. During the 13th Five-Year Plan period, the major project of “Children’s Drug Variety and Key Technology Research and Development” led by Beijing Children’s Hospital Affiliated to Capital Medical University, supported the development of a number of traditional Chinese medicine products and accelerated It has achieved the modernization, industrialization and high-quality development of traditional Chinese medicine! We look forward to more TCM products to be launched in the future to meet the actual clinical drug needs!
At present, traditional Chinese medicine products, especially Chinese patent medicines, are widely used in the field of pediatrics, but children’s traditional Chinese medicines are faced with taste Many problems such as bitterness, poor taste, and large dosage are urgently needed by clinical institutions, scientific research institutes, R&D enterprises and other advantageous resources to cooperate and solve together. It is expected that the Pediatric Medicine Alliance will continue to promote multi-party linkage, carry out multi-disciplinary exchanges, and gradually solve the key technical problems faced by the development of children’s traditional Chinese medicine!
Children’s Chinese patent medicine is a combination of the holistic view of traditional Chinese medicine and individualized and precise treatment. It is convenient to take, has few adverse reactions, high safety, and avoids the resistance and resistance of western medicine treatment. Side effects, a reasonable combination of Chinese and Western medicines can have the effect of enhancing efficacy and reducing toxicity, and children have better compliance than traditional Chinese medicine decoction. However, there are still problems in the classification of Chinese patent medicines for children, dosage form specifications, instruction information, packaging, odor and taste, preparation technology and quality control. It is expected that under the continuous guidance of national policies, children’s Chinese patent medicine can develop according to law, inherit the essence, and keep upright and innovate!
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Traditional Chinese medicines should be precisely positioned from the three aspects of disease combination, syndrome combination, and integration of Chinese and Western medicine, carry out post-marketing evaluation, and at the same time. When choosing a dominant disease in drug research and development, it is necessary not only to study the macroscopic syndrome of traditional Chinese medicine, but also to discuss the disease, and to try to narrow it down to a certain stage of the disease, so as to achieve precise research and development. The purpose of precise positioning, evaluation, and research and development of Chinese patent medicines is precise treatment, but this is only one aspect of improving the efficacy. Synergism and avoiding overlapping (over) treatments are one of the issues that need to be studied and discussed in the future.
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Children’s traditional Chinese medicine preparations lack special dosage forms for children, special specifications, extremely bitter taste, easy precipitation during storage, and difficulty in granulation. become a key scientific problem to be solved urgently. “Improving and innovating” the existing traditional Chinese medicine preparations is an advantageous strategy to solve the problem of children’s medicine. Looking forward to the improvement and innovation of traditional Chinese medicine in the future, such as changing the dosage form, changing process, changing the route of administration, adding new indications, and adding new drug users, in-depth cooperation between industry, academia and research, breakthroughs in key technologies, construction and improvement of various evaluation systems, and exploration of existing human experience. The clinical research model of traditional Chinese medicine, research and development of children’s special traditional Chinese medicine products, improve the quality of traditional Chinese medicine products, and give full play to the role and advantages of traditional Chinese medicine in the field of children’s disease treatment!
Chinese patent medicine is the treasure of our Chinese nation and the cultural crystallization of thousands of years! In recent years, the state has also issued a series of policies to support the development of traditional Chinese medicine. I look forward to exploring the methods and paths of traditional Chinese medicine innovation with the joint efforts of colleagues in the industry, not only looking for innovative inspiration from ancient classic medical books, but also learning and drawing on modern advanced science and technology, and applying the results to clinical practice in a timely manner. Help to improve the clinical treatment effect!
The application and development of traditional Chinese medicine for children is inseparable from the popularization and education of a well-established system of traditional Chinese medicine theory, technology and knowledge, including for doctors of traditional Chinese medicine. , Western medicine doctors, pharmacists, the public, etc. clinical science popularization work. It is hoped that in the future, traditional Chinese medicine will integrate scientific research and clinical practice experience in many aspects such as clinical research, complete instruction information, and clinical precision treatment, and use modern technical means to better promote the application of traditional Chinese medicine in pediatric clinics!
p>The innovative development of traditional Chinese medicine is inseparable from the positive progress of clinical needs and basic theory of traditional Chinese medicine. The confidential combination of clinical and scientific research will be conducive to promoting the inheritance and innovative development of traditional Chinese medicine. With the advancement of new technologies and new means, the development of new preparations of traditional Chinese medicine has great potential for development and room for improvement.
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In the national “Major New Drug Creation” Science and Technology Major Project – “Children’s Drug Varieties and Key Technology Research and Development”, the exploration of improved new drugs for children’s traditional Chinese medicine is also Some results have been achieved. In the pharmaceutical development stage, it is necessary to ensure good stability, controllable quality, and intellectual property protection of drugs; at the same time, clinical trials need to be pioneered and innovative, and to strengthen communication with CDE; in the process of industrialization, the feasibility of improved preparations of traditional Chinese medicines for children should be considered as a whole. Comprehensive evaluation of the whole process of new drug development will greatly improve the success rate of drug development. It is believed that with the further improvement of the policy system and laws and regulations in the future, the innovative preparations of traditional Chinese medicine for children will usher in a faster and better development.
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Chinese medicinal preparations generally have problems of poor taste and poor patient compliance. This has become one of the pain points restricting the high-quality development of traditional Chinese medicine preparations for children. Based on the “shotgun theory”, Yi Poinsettia Pharmaceutical’s strategy of suppressing bitterness and masking tastes, from changing the phase composition, cutting off the source of the formation of bitter taste signals (blocking the contact between receptors and ligands) to interfering with the formation and conduction process of signals (competing for the formation of bitter taste signals) and the target in the conduction pathway), to achieve a multi-level overall effect of suppressing bitterness and masking taste, and developed a series of products, looking forward to children’s medication-friendly traditional Chinese medicine products to provide more choices for clinical medication!
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In the actual use of traditional Chinese medicine, the public often faces two major problems. It is difficult to obtain professional knowledge of traditional Chinese medicine, and it is difficult to carry out extensive use without professional guidance. At the same time, how to choose between traditional Chinese medicine and western medicine is also one of the difficulties that troubles the public. Looking forward to more professional popular science education and public exchange activities in the future, to improve the public’s understanding of traditional Chinese medicine for children, and to further strengthen the popularization of knowledge of traditional Chinese medicine!
The development of traditional Chinese medicine for children is inseparable from the support of policies, technologies and funds. The alliance is willing to join hands with all walks of life to promote the linkage of “government-industry-university-research-medicine-funding”, continue to give full play to the advantages of the platform, integrate resources, strengthen communication between relevant departments and enterprises, and jointly promote academic exchanges in the field of children’s traditional Chinese medicine.Through the docking of flow and industrialization, create a closed-loop industrial ecosystem of traditional Chinese medicine for children, and benefit more children patients!
At present, the Pediatric Medicine Alliance has started the recruitment of the second batch of member units, and looks forward to cooperating with more outstanding industry colleagues, working together to create Efforts are made to promote the efficient, high-quality and innovative development of children’s medicines in my country!
Click “[Pediatric Drug Alliance] Second Batch of Member Unit Recruitment Notice” for more recruiting information.
Next notice
The August Symposium of China Children’s Drug R&D and Industrialization Alliance will be held on August 24, 2022< /span>Held online, focusing on the theme “Application and Development of Children’s Medicinal Excipients”, sincerely invite you to pay attention to children’s medicine colleagues to participate in the meeting to jointly protect children’s health.
How to participate:Long press the picture Scan the code to register immediately↓
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