Use the right medicine, don't "pa" | Xueba Notes · Xiehe Eight

Editor’s note:

When studying pharmacology, are you also interested in the intricate mechanism of action of various drugs, various clinical applications, various Headaches from adverse reactions and contraindications? Don’t worry, Xiehe 8 will launch a series of academic notes to review and sort out the pharmacology content with you.

Parkinson’s disease (PD) is a common neurodegenerative disease Symptoms include tremor, bradykinesia, and muscle rigidity. As the disease progresses, the symptoms will gradually worsen, and the patient may have difficulty maintaining posture and balance, reduced facial expressions, slurred speech, difficulty in writing, and writing too small… It is often accompanied by problems such as difficulty in thinking, emotional changes, and sleep disturbances.

my country is the largest country with PD, and Parkinson’s disease has plagued a large number of patients and families, bringing a heavy burden. Drug therapy is the treatment of choice for Parkinson’s disease. This issue of Xueba’s notes will start from the mechanism of Parkinson’s disease and sort out anti-Parkinson’s drugs. Let’s learn together~

(Some pictures need to be viewed horizontally)

I. Understanding the treatment ideas from the pathogenic mechanism

The balance of dopamine-choline at the level of striatum and substantia nigra is disrupted, the relative lack of dopamine and the relative function of acetylcholine hyperactive.