How can 20,000 yuan of onychomycosis become severe liver damage? Zhejiang No. 1 expert: Don’t take “medicine” indiscriminately!

It’s getting hotter

Sister Wang (pseudonym) who sells electronic products for charity in Jinhua Wu

Always feel sleepy

Not only that, but she also lost her appetite and felt weak

Pee turned golden yellow

Go to the hospital for a check

It turned out to be moderate to severe liver damage

nearly progressed to liver failure

How could it be so serious?

Department of Infectious Diseases, The First Affiliated Hospital of Zhejiang University School of Medicine

Breakout

“The culprit” and Sister Wang self-treat onychomycosis

And oral “health supplements” are closely related

all of this

It will also start with the story of her being marketed in the market last October

Jinhua sister’s vegetable market was promoted and spent 20,000 yuan for the treatment of onychomycosis

Sister Wang, Jinhua Wuyiren, 51 years old this year, and her husband sold digital cameras in the local digital city when they were young, and saved some money. Now that her husband continues to do business outside, she is free, and the most important thing is her daughter’s marriage.

Seeing that her 25-year-old daughter has reached the age to talk about marriage, her boyfriend is also a talented person. According to Sister Wang’s plan – the daughter will receive the certificate in 2021, and she will have her grandson in 2022. Dedicate yourself to helping bring your child.

Last year, my daughter’s marriage was a sure thing, but Sister Wang stared at her right hand and became more and more dissatisfied. It turns out that since 2015, Ms. Wang’s right hand has two onychomycosis, which are distributed on thumb and ring finger, and her feet also have Multiple onychomycosis. “At the wedding, as soon as I stretched out my hand, I was found to be onychomycosis. I was so embarrassed that I couldn’t shake hands with people. If my grandson came out, toenail fungus would be contagious. How could I help them take care of their children!”

In August 2021, Sister Wang, who went to the vegetable market to buy vegetables, “ran into” a salesperson who came to sell the treatment of onychomycosis. Ms. Wang, who was eager for treatment, was taken to the “XX Bright Armor” store by the sales staff, where she soaked in potion, rubbed onychomycosis, applied medicine, bandaged the sick nail, and massaged her hands and feet. After the operation, the salesperson promised Sister Wang. As long as you insist on coming to the store for treatment once a week, “3 months of 2,800 yuan will be cured.”

Sister Wang recalled that after paying the money, the sales staff greeting and answering any questions on WeChat every day, and urging her every two or three days Take pictures of onychomycosis to check the recovery. She also goes to the “XX Bright Nail” shop every week to polish and apply medicine.

In October 2021, two months later, Sister Wang’s onychomycosis has not been cured, and the sales staff recommended “XX Xiao Brand XX Xiao Oral Liquid” and “XX Brand XX” to her. There are four kinds of health care products, including wolfberry and American ginseng tablets, XX brand vitamin B2 multi-mineral tablets, and XX force pumpkin seed compound protein solid drink. , thereby repairing onychomycosis”. Especially “XX Xiao Brand XX Xiao Oral Liquid”, can not only cure onychomycosis but also improve sleep. In view of Ms. Wang’s severe onychomycosis, the sales staff suggested her to eat a box of onychomycosis every day. (6 sticks), three times a day, two sticks at a time, 118 yuan per box. Buy a box of 120 boxes to get 20 boxes, buy 30 boxes to get 3 boxes.

Sister Wang’s health care products for onychomycosis

From October last year to March this year, I ate it for nearly 5 months without telling my husband and daughter, purchased 105 boxes “XX Xiao Brand XX Xiao” Oral liquid”, and several boxes of “XX brand XX wolfberry and American ginseng tablets”, “XX brand vitamin B2 multi-mineral tablets”, “XX force pumpkin seed compound protein solid drink”, spent more than 20,000 yuan before and after. , the foot, right thumb and ring finger are still not healed.

She felt distressed that the medicine was too expensive, and she also reduced the number of “XX Xiao Brand XX Xiao Oral Liquid” from 6 to 4 per day.

Sister Wang’s nail fungus

Onychomycosis is not cured, but liver function indicators are not good

In February of this year, Ms. Wang began to feel that something was wrong with her body. She was always energetic and spirited. Not only fatigued, but also loss of appetite, nausea and vomiting, yellow urine. My husband was worried about Sister Wang’s health, so he took her to a local hospital for a check-up. The results of the blood draw were astonishing – two indicators of Sister Wang’s liver function “Alanine aminotransferase” and “Aspartate aminotransferase” strong>More than twice the normal value, suspected “immune liver disease”, she was diagnosed with “abnormal liver function” and was hospitalized.

What puzzled the medical staff of the local hospital was that after treatment, Sister Wang’s liver function index did not improve, but instead increased higher and higher. Doctors who have studied in the First Hospital of Zhejiang University strongly recommended Sister Wang to come to the Department of Infectious Diseases of the First Hospital of Zhejiang University for treatment, and thoroughly investigate the cause of the “abnormal liver function”.

In mid-March, Sister Wang came to the expert clinic of Chief Physician Sheng Jifang, Director of the Department of Infectious Diseases of the First Hospital of Zhejiang University. “When she first came, her mental state was not very good. Her complexion was dark and yellow, and her skin was dark and rough, and she had no strength to walk.” Director Sheng introduced that after conducting a comprehensive liver function examination on Sister Wang again, compared with previous examinations, she “Alanine aminotransferase”, “aspartate aminotransferase” and other liver function indicators are still rising! And severe yellow urine, fatty liver and gallbladder wall thickening.

Seeing the onychomycosis on Sister Wang’s hand, Director Sheng asked Sister Wang in detail what food and medicine she had eaten recently. I immediately found the source of the problem. The instruction manual of this oral solution states that the main ingredients are Shouwu Teng (the cane of He Shouwu), Acanthopanax 5+, etc. The comprehensive medical examination of Sister Wang has never appeared in her annual physical examination. Abnormal liver function and no history of liver disease, viral hepatitis and autoimmune hepatitis were completely ruled out, and she was determined to be drug-induced liver damage, liver insufficiency.

The “culprit” was found. After half a month of a series of drugs and liver protection treatments, Sister Wang’s liver function basically improved and she was discharged from the hospital smoothly.

To treat onychomycosis, is it not possible to take oral medicine? wrong!

“XX Xiao Brand XX Xiao Oral Liquid” taken by Sister Wang is clearly marked on the cover of the box “Health food is not a medicine and cannot replace medicine to treat diseases”. As it is marked, it is a food, not a drug, and it cannot replace drugs to treat diseases. Experts have repeatedly emphasized the need to “eat health care products with caution”.

Professor Sheng Jifang introduced that this health food contains anthraquinones, phenols, flavonoids, stilbene glycosides and other ingredients. In recent years, there have been clinical cases of Shouwu teng, raw and processed Polygonum multiflorum products causing liver injury adverse reactions, so clinicians hardly use them, and it is easy to cause liver injury. strong>Drug-induced liver disease.

In recent years, the number of cases of drug-induced liver injury reported by various clinical departments in my country has increased, which has attracted industry attention. The world’s largest drug-induced liver injury database – China Drug-induced Liver Injury Professional Network, conducted a retrospective epidemiological study on the occurrence and treatment of drug-induced liver injury in hospitalized patients in my country. Drug-induced liver damage occurred in 1.75 patients.. Clinically, experts have also received more and more patients with liver damage caused by irregular use of health products, Chinese herbal medicines, and diet pills.

Q

Why do so many people choose to self-treat onychomycosis?

A: Some patients feel that it is not worth going to the hospital for minor problems, and some patients feel that onychomycosis is as difficult to eradicate as athlete’s foot, so they treat themselves. The dermatology department of a regular tertiary hospital conducts systematic treatment, onychomycosis can be eradicated.

Q

So to treat onychomycosis, is it not possible to take oral medicine?

A:The answer is no. Qiao Jianjun, deputy director of the Department of Dermatology of Zhejiang University First Hospital (in charge of the work), introduced that onychomycosis is a disease caused by lesions caused by fungal invasion of the deck and surrounding tissues. If you want to treat , it is necessary to completely kill the hidden on deck under fungi.

For mild onychomycosis: topical antifungal drugs

For moderate-to-severe onychomycosis: Under the guidance of a doctor, take orally terbinafine, itraconazole and other drugs used to treat fungus.

“During taking the medicine, please follow the doctor’s advice, and the regular use of oral medicine to treat the probability of liver damage in onychomycosis

“strong>Only 1 in 10,000 to 1 in 100,000. “Introduced by Chief Physician Qiao Jianjun.