Text/Yangcheng Evening News All-Media Reporter Xue Renzheng
Correspondent Ling Weiming
Photo/Provided by the hospital
Recently, the Southern Hospital of Southern Medical University (hereinafter referred to as “” The Department of Infectious Medicine of Nanfang Hospital”) successfully performed autologous hematopoietic stem cell transplantation for a patient with HIV complicated by lymphoma. Fill the gaps in related fields.
Can I just give up if HIV is combined with other diseases?
AIDS (AIDS) is a highly harmful infectious disease caused by infection with human immunodeficiency virus (HIV), which can attack the immune system of the human body, destroy a large number of immune cells, and make the human body lose immunity. .
According to the introduction of Peng Jie, chief physician of the Department of Infectious Medicine of Nanfang Hospital, HIV-infected patients are more likely to develop opportunistic infections and opportunistic tumors than the general population due to the destruction of their immune systems. Since HIV targets CD4+ T lymphocytes in the human immune system, lymphoma patients are the most common in HIV patients with malignant tumors.
“During the past period of scarcity of antiviral drugs, HIV-infected patients were 100-500 times more likely to develop lymphoma than the general population. Even now that we have excellent drugs to control AIDS, HIV-infected patients are more likely to develop lymphoma than the general population. The total risk of lymphoma is also 11 times higher than that of the general population, with an estimated incidence of 193/100,000.” Peng Jie told reporters that among the surviving HIV-infected patients in China, the number of patients with lymphoma is very large. However, these patients have been difficult to receive effective treatment for a long time.
Patients undergoing peripheral blood stem cell reinfusion
“Most hospitals are more concerned about the Antiviral therapy is often helpless for the treatment of combined tumors. This is a medical problem and a social problem.” Peng Jie said that HIV-infected patients have poor immune function themselves, and combined with lymphoma, resulting in double immune deficiency, compared with the general population, Tumors are more aggressive, have a higher risk of infection, have a worse prognosis, and are more difficult to treat. Therefore, in the past, many patients with AIDS and tumors were abandoned, which made him feel particularly distressed.
“In order to solve the treatment problems of HIV-combined lymphoma patients, the Department of Infectious Diseases of Nanfang Hospital has set up a multidisciplinary treatment team. The ability to diagnose and treat.” Peng Jie said, “In order to avoid the spread of the virus, strict infection prevention and anti-infection management are required during diagnosis, treatment and transplantation, which is also the strength of our department of infection medicine.”
Patients re-transfused hematopoietic stem cells
In April 2022, the Department of Infectious Medicine of Southern Hospital successfully performed autologous hematopoietic stem cells for HIV patients with lymphoma Transplantation is the first related treatment performed by the infectious disease department in China, and also the first HIV-associated lymphoma autologous hematopoietic stem cell transplantation in South China.
The biggest difficulty faced by HIV-infected people is discrimination
“HIV-infected people are a vulnerable group, and some hospitals, considering the infectivity of the virus and the uncertainty of the patient’s physical condition, do not I am willing to provide them with treatment,” Peng Jie said.
“We have been preparing for this surgery for HIV patients with lymphoma for more than a year.” Chen Juanjuan, chief physician of the Department of Infectious Medicine, Nanfang Hospital, introduced: “In the process of preparation, we felt that the most difficult thing was social discrimination. Problem.” It is understood that before transplantation, the patient’s hematopoietic stem cells need to be taken out as “seeds”, frozen in a low-temperature environment, and after the patient’s bone marrow has been removed, the “seeds” are sowed and waited for it to “root” and “germinate” ”, allowing the patient’s immune system to rebuild. In the process of freezing the “seed,” they ran into big trouble.
Doctors cryopreserve hematopoietic stem cells for patients
“Many third-party cryopreservation institutions are reluctant to accept In the end, we can only invest heavily in virus specimens and make our own.” Chen Juanjuan said, the medical team spent a long time purchasing and debugging a lot of related equipment and reagents, and finally found an optimal solution that can It is guaranteed that the “seed” has almost no loss during the freezing process.
“It costs us a lot to solve the various problems encountered during the operation, but life is paramount, no matter how much effort we put in, it’s worth it,” said Peng Jie.
Finally, this patient’s autologous hematopoietic stem cell transplantation was very successful. “Usually it takes about 15 days for the recovery of leukocytes after surgery, but this patient had granulocyte reconstruction in 12 days. The reconstruction of platelets was also significantly earlier than the 39 days reported in the literature, and it took only 21 days, the most difficult reconstruction. The platelets were also implanted successfully.” Peng Jie said with a smile.
Patients were successfully cured and discharged
It is understood that the Department of Infectious Diseases of Southern Hospital has been devoted to treating HIV-infected patients for many years. To help vulnerable groups, a lot of academic research and technology sharing have been carried out, striving to “benefit patients across the country” with relevant medical achievements.