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Ibuprofen is an antipyretic and analgesic non-steroidal anti-inflammatory drug that can be used for pain relief, antipyretic, and treatment of various arthritis.
In clinical practice, what are the symptoms of ibuprofen overdose? How to deal with it? Follow Jie Xiaoyao, let’s take a look together!
Suspension drops, tablets
Overperformance
Do not exceed the recommended dose, otherwise it may cause headache, vomiting, fatigue, low blood pressure and rash, etc.[1].
Solution
In the case of an acute overdose, gastric lavage should be performed by vomiting or lavage, but there is little recovery by gastric lavage more than an hour after taking the drug. Because this drug is acidic and is excreted in the urine, it is theoretically beneficial to take a base and induce a diuresis.
In addition to supportive care, oral activated charcoal can help reduce the absorption and reabsorption of ibuprofen tablets [2-3].
Sustained-release capsules, injections, suspensions
Overperformance
Ibuprofen overdose toxicity depends on the amount of drug ingested and the time elapsed since ingestion, and individual responses may vary, making it necessary to evaluate each case individually.
Although the medical literature on ibuprofen overdose reports serious toxicity and death from overdose, these are uncommon.
The most common symptoms of an ibuprofen overdose include abdominal pain, nausea, vomiting, lethargy, and lethargy. Other CNS symptoms include headache, tinnitus, CNS depression, and seizures. Metabolic acidosis, coma, acute renal failure, and apnea (mainly in very young children) may rarely occur.
Cardiovascular toxicities, including hypotension, bradycardia, tachycardia, and atrial fibrillation, have also been reported [4].
Solution
Because there is no known antidote for ibuprofen, symptom relief and supportive care should be used in the event of an overdose. Diuresis, urine alkalization, hemodialysis or blood perfusion may be useless due to the high protein binding of ibuprofen [5].
Treatment of acute ibuprofen overdose is primarily supportive. Hypotension, acidosis, and gastrointestinal bleeding in overdose may need to be treated. In cases of acute overdose, the stomach should be emptied by induced emesis or lavage. It is most effective to induce vomiting within 30 minutes after ingestion. Oral activated charcoal may help reduce the absorption and reabsorption of ibuprofen.
In children, estimated ibuprofen intake by weight may help predict the likelihood of developing toxicity, although a Evaluate.
Ingestion of less than 100 mg/kg is unlikely to be toxic; 100-200 mg/kg in children can be managed by induction of vomiting and a minimum observation period of 4 hours; ingested by children Immediate gastric emptying should be performed at 200-400 mg/kg ibuprofen and observed in a medical facility for at least 4 hours; children ingesting more than 400 mg/kg require immediate medical attention, careful observation, and appropriate supportive care. Overdose over 400 mg/kg is not recommended to induce vomiting due to the risk of convulsions and the possibility of aspiration of gastric contents.
Historical data on reported overdose do not appear to predict toxicity in adult patients. The need for referral and follow-up must be judged based on the situation at the time of overdose. Symptomatic adult patients should be carefully evaluated, observed, and supported [4].
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