What are the main functions of statins?

1, hypolipidemic function

It is mainly reflected in lowering cholesterol, which can effectively reduce low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, which are one of the main culprits of arteriosclerosis. increase high-density lipoprotein cholesterol.

Statins are a relatively common drug in clinical medicine and life, and can also reduce triglyceride levels. The role of esters.

2. The role of stabilizing arteriosclerotic plaque span>

Atherosclerotic plaque on the wall of each person’s blood vessel is composed of a very thin layer of fibrous tissue and some localized substances on the surface , this thin layer of fibrous tissue is very easy to rupture, causing the material in the plaque to gradually fall off.

As the blood flows to the distal end, it is easy to form myocardial infarction and cerebral infarction, so statins are Clinically, it has the functions of stabilizing arteriosclerotic plaque, avoiding plaque rupture and emboli shedding.

3. Anti-inflammatory function

This effect is reflected in long-term stable oral statin patients. After taking statins for 2 to 4 years, patients will find that the atherosclerotic plaques on the skin are significantly reduced. There are even many patients with sclerotic plaques disappearing.

Can statins be taken long-term?

Statins are a common drug for many patients with cardiovascular and cerebrovascular diseases. This drug has the effects of lowering blood lipids and anti-arteriosclerosis. When your body does not have any adverse reactions, you can take it for a long time according to the doctor’s advice.

If there are no adverse reactions, patients with cardiovascular and cerebrovascular diseases also need long-term use. Adverse reactions should be strictly monitored during the process.

Similar to the common adverse reactions of statins, if there is damage to liver function, it is necessary to observe whether the patient will have this aspect. damage.

Many people also experience symptoms such as yellow skin or eyes and liver discomfort, or are accompanied by these symptoms. When there are signs of abnormal function, everyone should go to the hospital for examination and treatment in time, and strictly monitor the liver function to see if the long-term use of statins has caused liver damage.

In addition to the liver, many patients may experience muscle damage when taking statins for a long time , if the patient has muscle pain and muscle soreness and a feeling of general weakness.

Then everyone must go to a regular hospital for examination and treatment. The relevant indicator for examination is creatine kinase. Whether creatine kinase is elevated.

Doctor’s suggestion: During taking statin, there are 4 things that are best not to touch, eat wrong Not a trivial matter, pay attention

Rough grains

When taking statins in daily life, be sure to eat less whole grains, such as fruits, oats, corn, etc., according to the doctor’s advice.

Because whole grains contain a lot of fiber, this substance will affect the absorption and utilization of statins in the body , and also prolongs the time the drug stays in the blood.

Grapefruit

When patients take statins for a long time, they should be careful not to take them together with fruit grapefruit, because statins are eventually excreted from the body through dry metabolism and metabolized in the liver. During the process, a large amount of cytochrome enzymes is required for metabolism.

It happens that some substances contained in grapefruit can inhibit the activity of cytochrome enzymes, causing him to experience the concentration of the drug in the blood Gradually increase, compared with drugs, the adverse reactions of drugs will gradually increase, so you can’t eat grapefruit when taking statins.

Monascus products

If you want to take it according to the doctor’s advice for a long time, statins are usually best to eat less or not eat peacock products, such as red rice, red grass and other foods .

Because the process of taking red yeast rice products and statins at the same time will cause adsorption and wandering back and forth in the body, For example, muscle soreness may have very adverse effects on other tissue cells in the body, so everyone must pay attention.

Drinks

When taking statins, you must remember not to drink alcohol, because after alcohol enters the body, it needs to be decomposed and metabolized by the liver, and statins Drugs happen to need the liver to help metabolize them.

Therefore, drinking alcohol while taking the medicine will undoubtedly increase the burden on the kidneys and increase the risk of liver damage. For the sake of health, everyone takes this medicine. Do not drink alcohol while taking the medicine.

Best time to take a statin

Short-acting statins

Short-acting statins, doctors recommend that general patients take these drugs at night. Patients taking these drugs at night can gradually reduce their total cholesterol levels. In addition, taking statins at night has the best effect because at this time The activity of cholesterol-producing liver enzymes gradually increases.

Long-acting statins

It takes longer for the human body to process long-acting statins, which generally have a half-life of about 19 hours.

Therefore, long-acting drugs work well whether they are taken in the morning or in the evening, so patients who take statins for a long time can choose the time of day that suits them best. .

How to choose a drug under different circumstances?

1. Patients with abnormal liver function: Choose pravastatin and rosu Vastatin, atorvastatin and fluvastatin should be carefully selected.

2. Patients with abnormal renal function: Atorvastatin and fluvastatin can be selected, and pravastatin and rosuvastatin can be selected carefully.

3. Diabetic patients: can choose general vastatin and pitavastatin.

4. Patients with myalgia after taking medication: can be changed Use pravastatin or fluvastatin.

5. Patients with insomnia and headache: Choose pravastatin or rosuvastatin.

6. Gout patients: Ato is preferred Vastatin, rosuvastatin can also be selected, lovastatin is contraindicated.

Concluding remarks:As people’s living standards increase, With the continuous improvement, the number of people with high blood lipids and high cholesterol has become more and more, so statins have become a commonly used drug in clinical medicine. Therefore, it is important for everyone to know some knowledge about statins. Very important, even if the individual does not have hypercholesterolemia, but this can also be a good reminder to family members to pay attention to this aspect.

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