Every patient who has gout will ask himself why it is me who has gout. I am still so young and I don’t drink alcohol. My family No one has the disease of gout, why is it my turn to have such a troublesome disease? Is it because of my character? Please don’t have such a feeling of complaining, friends of gout. Today I will tell you the reasons for gout, and analyze why you have gout through three questions.
1. Genetic problems
The occurrence of many diseases is actually related to heredity The factors are highly correlated. It can be said that the information code of human beings is hidden in this nucleus. It can be said that the genetic characteristics have been determined from the gestation period of life. Likewise, heredity determines much of your future health.
Similarly, as a disease, gout also has certain heredity. If there are people with gout in both parents or in the family, then the descendants of the same family will have gout. This Genetic factors are like a brand that penetrates deeply into the family, so if you have gout, you must find someone who is not gout when looking for a partner, otherwise the offspring will basically be unable to escape the trouble of gout. , of course, there will be special cases, which may be a small probability event.
Although genetic factors play an important role in whether or not to get gout in the later stage, it does not mean that genetic factors determine the disease. In addition to genetic factors, many diseases also have various external factors. The result of interaction, so everyone should not have negative thoughts, thinking that as long as the family has gout, you will definitely get gout. This is actually a matter of probability. It only indicates that the possibility of developing gout is relatively high, not that you will definitely get gout. this disease.
2. Metabolic problems
The current key point in the occurrence of gout is located in the excessive uric acid in the blood. High, because uric acid has a certain solubility, beyond this limit, crystals will be precipitated and deposited all over the body, causing inflammation, so where does this uric acid come from? A metabolic problem needs to be introduced here, which is what we often call purine metabolism.
Purine metabolism refers to a process of synthesis or decomposition of purine derivatives of nucleic acid bases in the human body. The human cell nucleus contains a large amount of genetic information, which is required for information recording. The material basis of these nucleic acids is these nucleic acids. The metabolism of nucleic acids involves the problem of purine metabolism. Eventually, these substances will form uric acid through various metabolic processes. The process is very complicated and involves multiple organs. , tissues, cells, etc. are completed together, but the core process is the formation of uric acid, a process in which most of the substances are excreted through the kidneys or intestines, except for part of the recycling.
In this complex process, as long as there is an error or omission in one link, the final result may be disordered in purine metabolism, resulting in the continuous accumulation of uric acid in the blood beyond the normal range. Eventually a gout attack occurred. For example, the human body needs a lot of oxygen during strenuous exercise, and due to some special reasons, the oxygen supply is insufficient, and the human body cannot maintain balance through compensation, which will inevitably lead to metabolic problems in some cells in the body. Often a terrifying cascade, the final consequence may be partial apoptosis.
Dead cells need to be cleaned up after they become inactive, and this cleaning process involves the decomposition of the nucleus, so the purine metabolism becomes active, and this active Once the degree exceeds the range that the human body can bear, it may eventually lead to the formation of a large amount of uric acid. After it is formed, it needs to rely on the kidneys or the gastrointestinal tract for further metabolism. If these functions are normal, then the human body can excrete this excess uric acid from the body, but what if there is a problem with these excretion systems? The final consequence may be the rapid accumulation of uric acid in the body, which exceeds the normal range, so the metabolism in the body has a very large impact on the onset of gout, which involves genetic problems, various organ problems, and even the metabolic process. Various proteins, enzymes, molecules, etc. interact with each other.
3. Diet problems
Many people would say that gout is a disease that comes from eating , because once you have gout, there will be a process of diet control. Gradually, everyone thinks that the disease of gout is caused by eating too many things that should not be eaten. Among them, the most concernedIt is a high-purine diet. There is no problem with this concept, but what I want to tell you is that the purine intake in the diet has little effect on the entire purine metabolism of the human body. If there is no problem with the normal metabolism in the body, then even a large amount of purines Dietary intake in the body does not necessarily lead to excessive uric acid in the body, so I remind everyone here that diet is an important issue in the cause of gout, but it is not the only key issue.
When the body’s own purine metabolism has problems, or when the current balance is barely maintained, the diet exceeds the standard again. At this time, the increase of uric acid may seem to be higher than the diet. For example, a patient who was found to have high uric acid in a physical examination, but who has not suffered an acute gout attack, may not have any discomfort at this time, and even sometimes the blood uric acid is still in the normal range. This is what we often call the tolerance stage. That is to say, the human body can still bear the increase of uric acid. At this time, if you don’t pay enough attention to continue a high-purine diet, then I am sorry, your uric acid may explode due to dietary factors, so it is said that diet is important for increased uric acid and gout attacks If there is a certain promotion effect, you can find a promotion effect, which is also a certain premise.