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Myelodysplastic syndrome is a group of heterogeneous hematopoietic cell dysplasia, and some patients can be transformed into acute leukemia. The prognosis of myelodysplastic syndrome is related to the patient’s age and physical symptoms, peripheral blood and bone marrow images, and chromosomal abnormalities.
>Why get MDS?
The causes of myelodysplastic syndromes are not well understood, such as radiation, toxic Chemical objects, paints, adhesives, major trauma, environmental pollution, etc. The disease is more common in middle-aged and older people. The prognosis of the elderly with MDS is worse than that of middle-aged people. The curative effect is also poor.
> Will peripheral blood and bone marrow images affect prognosis?
In patients with myelodysplastic syndrome-RA and RAS, nucleated red blood cells can be seen in peripheral blood , Pseudo-pelger-Huet abnormality, lymphoid small megakaryocytes, etc., accompanied by an increase in the proportion of primitive and immature cells. This situation can easily be transformed into leukemia. The presence of blasts in the blood of patients with myelodysplastic syndromes or blasts >=0.05 in the bone marrow indicates a poor prognosis. Among the RAEB-T subtypes, patients with positive Auer bodies (rod-shaped bodies) in problasts in the blood picture bone marrow have a higher complete remission rate and longer survival time than patients with negative Auer bodies.
Do chromosomal abnormalities affect prognosis?
Myelodysplastic syndrome is an abnormality of pluripotent hematopoietic stem cells. The diseased blood cells produced by abnormal stem cells are all clonal. Myelodysplastic syndrome patients with abnormal karyotype have a shorter median survival, especially those with complex chromosomal abnormalities, and the prognosis is better. Difference.
currently Objectively speaking, there is no effective treatment method in the world. The clinical treatment method of integrating traditional Chinese and Western medicine to regulate blood production has an ideal effect. Through traditional Chinese medicine syndrome differentiation, according to the patient group (low-risk group, high-risk group) and syndrome type group, the prescriptions are selected. Combined treatment and mutual cooperation can significantly improve the clinical efficacy of myelodysplastic syndrome, a chronic and severe disease.
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