In the fourth episode of the hit emergency medical TV series, a strange patient arrives at the emergency room. A man in purple pyjamas lay on a hospital bed screaming in pain but refusing to explain his medical history. The female companion who accompanied him was very embarrassed. The nurse quickly went to the male doctor for treatment. Director Liu said with a solemn expression-priapism.
Director Jiang, who returned from studying abroad, was called to the “rescue scene”. After scanning his eyes, he concluded that nine times out of ten, it was because he had taken too much “Viagra”!
I. “Viagra” – Sildenafil
Sildenafil is known as a V-phosphodiesterase inhibitor and was used in the early stages of development Medications to treat pulmonary hypertension. After sildenafil is successfully developed, it can effectively expand the large and medium arteries of the human body. Later, it was found that it also has a good therapeutic effect on male dysfunction (ED) and became the first-line drug for the treatment of ED.
It turns out that in the process of using sildenafil, sildenafil has a particularly obvious auxiliary effect, that is, it Will produce a relaxation effect similar to that of vascular smooth muscle in male patients.
Because, after the smooth muscle of the corpus cavernosum relaxes, the volume of the corpus cavernosum will increase significantly, resulting in the prolapse of the corpus cavernosum. Therefore, sildenafil has gradually become a drug for the treatment of ED.
Second, is overdose of sildenafil harmful to the body?
If you take too much sildenafil each day, it may cause some risks and severe low blood pressure. However, if you only take it regularly, for example, you take it often, but in very small doses each time, it probably won’t have much of a negative effect.
If a patient takes an overdose of sildenafil on the same day or a single day, blood vessels in other parts of the body will dilate significantly, even if the patient overcomes the vasodilation to some extent, which can lead to Severe low blood pressure, but it is very unlikely.
Taking Sildenafil regularly dilates many blood vessels in the body, which is good for cardiovascular function. Long-term use of sildenafil can help manage chronic diseases.
In short, it’s not entirely true to say that regular intake of sildenafil can harm your body and health. As long as you use it correctly, the chances of experiencing abnormal physical symptoms are relatively small.
Third, is long-term use of sildenafil addictive?
With the development of science and technology, the pressure of life is increasing day by day. Especially male friends not only have to work hard, but also consider their families. Every day we face pressure from all angles. For a long time, we will inevitably be physically and mentally exhausted, and then may be in an unhealthy state, leading to the emergence of certain diseases, which will not only affect our health, but also affect the harmony of our family.
Therefore, some men are afraid of becoming addicted before taking this drug, but in fact, this is mainly due to the consequences of drug abuse. The long-term use of certain drugs inevitably leads to a state of dependence. Stopping the medication can cause some specific symptoms, known as this reaction. In our domestic medicine, addictive substances are strictly restricted by the clinical use of drugs specially managed by the state.
Sildenafil does not contain such ingredients, and rational drug use will not produce dependence on it.
Is there any side effects after stopping the drug? What are the side effects?
Many male friends often take sildenafil secretly at home, but some people worry that long-term use of sildenafil will make people addicted, and the condition will worsen after stopping the drug. Therefore, we should also note that sildenafil can only help male friends to improve their functions, but not to treat diseases. Therefore, sildenafil treats the symptoms, not the underlying cause. The male friend’s ED function did not improve after the drug was discontinued. Of course, medicine is three-point poisonous, and there will definitely be some side effects on the body.
Sildenafil inhibits and modulates the transmission of the light pathway to the retina. Some people may experience short-term blurred vision after taking the medication, and some may experience blue light illusions when the condition is severe. Therefore, for safety reasons, working at heights or driving a car after taking the drug is not recommended. If you experience any discomfort after stopping the drug, such as recurring illness and mild symptoms, you should seek medical attention as soon as possible. It’s also important to note that some people are more sensitive. They can have allergic reactions to certain medicines. In the process of using sildenafil, we should also observe whether allergic symptoms such as rash and itching occur. If any of the above symptoms occur, stop taking the medicine immediately.
5. How to properly take sildenafil?
Let’s take a look at the mechanism of action of sildenafil. Sildenafil stimulates the corpus cavernosum of the male reproductive organs, thereby increasing the strength of the organs’ muscles, rapidly congesting blood and rapidly reaching a state of tension. Due to its remarkable curative effect, it has also been widely used in clinical practice.
Sidenafil is widely used in the elderly population, the elderly should pay attention to the frequency of taking sildenafil. The dose of sildenafil is determined according to individual constitution, and the usual dose is 50 mg. Also, sildenafil is more effective when fasted. People should start taking small doses of sildenafil for the first time. The dose may be increased appropriately with continued use of this medication. If long-term patients find little effect, they may increase the dose to 100mg.
Patients taking sildenafil for a long time should pay attention to the frequency of use, and can only take sildenafil at most twice a week. If you take two doses in a short period of time, be sure to take them more than 24 hours apart. Patients over the age of 65 should take lower doses.
Six, follow three principles to use scientific medicine
1. Do not take it with nitrates
Patients should not take any form of sildenafil concurrently. Sildenafil itself is a drug used to treat cardiovascular disease. This is a strong acid antihypertensive drug. When taken with nitrates, it can cause vasodilation and low blood pressure. Therefore, sildenafil is not recommended for patients with cardiovascular and cerebrovascular diseases (such as myocardial infarction, stroke, and angina pectoris).
2. Do not eat too much the first time
The recommended maximum daily dose for an average healthy male is 100 mg. Based on this data requirement, is the recommended dose of 25 mg per dose repeated on the same day for middle-aged and elderly men? the answer is negative. In fact, adults, young and middle-aged or older and middle-aged cannot take effective doses of sildenafil (25 mg, 50 mg and 100 mg) on the same day (i.e. within 24 hours) Repeated use of sildenafil.
This mainly depends on the plasma half-life of sildenafil, as sildenafil is basically a foreign compound. Once a drug enters the body, it takes a specific absorption and metabolism time to be excreted. Half-life is when this process is considered. Based on the pharmacokinetic studies of sildenafil, it can be found that the drug enters the body (absorbed in the blood) with a half-life (half-life) of 4 hours at the highest concentration. After about six half-lives, the drug can be metabolized in the body. Therefore, sildenafil should only be used every 24 hours. If it is 25 mg, 50 mg or 100 mg, it is the effective dose. That is, it can only be used once per day.
3. Pay attention to the time of taking the medicine
Because sildenafil will be satiety Therefore, try not to drink alcohol or eat high-fat foods while taking the medicine, and try to take the medicine 2 hours after meals. When it comes to alcohol, we all know that alcohol stimulates the body’s blood vessels. The action of sildenafil in the body will also have a certain dilation effect on peripheral blood vessels. Therefore, when alcohol is used with sildenafil, it can easily cause low blood pressure. At the same time, alcohol also has a certain stimulating effect on the heart, so we should be vigilant.
Summary:
In general, the incidence of ED has increased significantly in recent years due to the combined effects of an aging population, poor health, and chronic diseases. Sildenafil is a drug commonly used in the treatment of ED in middle-aged and elderly men. Due to the decline of liver and kidney function in middle-aged and elderly people and the decline of human metabolic capacity, the potential risk of injury caused by this drug to these groups is great. Therefore, we should take care to prevent the adverse health risks caused by sildenafil.
It is worth noting that, in addition to the three situations not described in this article, in the initial stage of drug treatment, attention should be paid to the route of use, Contraindications and precautions in order to greatly improve the condition. Both Chinese and Western medicines have some side effects. Long-term use can have some negative effects on the body. Whether to take it requires detailed analysis. If the benefits of the treatment outweigh the disadvantages, you can continue to take it. As long as you have the relevant knowledge and take it under the guidance of a professional doctor, there will usually not be too many side effects.
References:
Sildenafil package insert (including FDA package insert)
< strong>2010 Edition “Guidelines for Diagnosis and Treatment of Pulmonary Hypertension in China”