(Health Times reporter Kong Tianjiao) The City of Hope research team recently announced that a 66-year-old AIDS patient has been “cured”, becoming the “Berlin Patient”, “London Patient” and “The London Patient”. The fourth patient to achieve long-term remission of AIDS through stem cell transplantation after the New York Patient.
Health Times compared the three previously cured AIDS patients and found that the “Berlin patient”, “London patient” and “New York patient” all received stem cell marrow transplants containing CCR5 gene mutations, but “hopefully”. Like the “Berlin patient” and the “London patient”, the “city” patient received a bone marrow transplant, while the “New York patient” transplanted stem cells from umbilical cord blood. All four patients underwent similar stem cell transplants, all of whom were “cured” from AIDS and blood cancers after stem cell transplants.
Relevant institutions distributed AIDS prevention materials to various key groups for free. Photo courtesy of China Association for the Prevention and Treatment of STDs and AIDS
“According to the relevant report of the research team of these four cured AIDS patients, CCR5 is a receptor on CD4-positive immune cells, and HIV The virus enters immune cells through this receptor and reproduces in it, and CCR5 gene mutation can prevent HIV virus from entering cells.” On July 31, an unnamed chief physician of the Department of Infectious Diseases of Beijing’s top three hospital pointed out, “According to existing This brings new hope to patients with AIDS and cancer.”
On July 27, the City of Hope research team announced that a 66-year-old The 20-year-old AIDS patient has been “cured” and has been off antiretroviral drugs for more than 17 months. Doctors have found no signs of HIV replication. After the “Berlin Patient”, “London Patient” and “New York Patient”, he became the fourth patient to achieve long-term remission of AIDS through stem cell transplantation.
Screenshot of the relevant research report of the US City of Hope research team
The research team pointed out that this patient He was diagnosed with HIV in 1988, diagnosed with acute myeloid leukemia (AML) in 2018, and received a stem cell transplant in 2019. The patient, who had been HIV-positive for more than 31 years at the time of treatment, was the oldest in three previous similar cures to be “cured” from HIV and blood cancer after a stem cell transplant.
Because the patient was 63 years old at the time of treatment and had a higher risk of complications after a stem cell transplant, the researchers designed a reduced-intensity pretransplant chemotherapy regimen. The researchers specifically selected a donor for him who carried a rare genetic mutation, the CCR5 gene deletion. Following treatment, the patient was in complete remission of leukemia and AIDS.
Before this, three AIDS patients were declared “cured”.
In 2009, German Gero Hütter and other research teams published in the “New England Journal of Medicine” and pointed out that after hematopoietic stem cell transplantation, the “Berlin patient” not only cured the leukemia, but also completely cured the HIV virus in the body. Disappeared. For more than a decade since then, he has not been tested for HIV and is considered cured of AIDS. In September 2020, he died of a relapse of leukemia.
On March 5, 2019, a study by Ravindra Gupta’s treatment team at University College London published in the top international academic journal “Nature” showed that the A “London patient” diagnosed with advanced Hodgkin lymphoma, the research team transplanted bone marrow stem cells from a donor with HIV-resistant gene for him in 2015. After stem cell transplantation, the HIV virus was completely removed from the patient’s blood. Disappeared. After 16 months, the patient was no longer taking anti-AIDS drugs. In February 2019, he had been successfully “discontinued” for 18 months, and there was still no sign of the virus. Become the second “cured” AIDS case.
Screenshot of related research published in Nature
February 15, 2022, University of California, Los Angeles A research team from UCLA and Johns Hopkins University reported at the Conference on Retroviruses and Opportunistic Infections (CROI) an AIDS treatment case: a female AIDS patient who underwent cord blood stem cell transplantation for acute myeloid leukemia Stop AIDS medicine. HIV has been undetectable for 14 months after drug treatment. Become the third “New York patient” to be cured.