Proteinuria is a mirror of renal function, which can reflect the quality of renal function to a certain extent. Almost 80% of patients with nephropathy are accompanied by symptoms of proteinuria, which is directly related to the impairment of glomerular filtration function. Proteinuria is also an independent factor affecting the progression of renal function, so it is the key “object” in the treatment of renal disease.
In order to prevent proteinuria from accelerating renal failure, kidney patients should be treated with timely medication and diet management to control the development of proteinuria. However, some patients have used some drugs, but the effect is not very obvious.
A lot of kidney friends leave a message: Medication change? Or continue to take medicine? Which drug is the best for reducing protein?
There are 3 kinds of commonly used drugs in nephrology, which can not only reduce protein but also protect kidney. The key is to use them correctly.
drop Protein drugs “big brother”——glucocorticoids
hormonal drugs are the most commonly used drugs in the treatment of nephropathy. However, because of its side effects, it is often complained by kidney disease patients, but its practical and good protein-lowering effect is very good.
The commonly used hormones in the treatment of nephropathy include prednisone, methylprednisone, betamethasone, prednisolone, etc. These drugs can be used alone or in combination, mainly by inhibiting the immune system in the kidneys. Inflammatory reaction, to achieve the purpose of eliminating kidney tissue inflammation and renal endotoxin, and at the same time play a role in protecting renal function, reducing glomerular filtration function, thereby reducing protein leakage.
It has obvious protein-lowering effect on the treatment of nephropathy with massive proteinuria, such as nephrotic syndrome: minimal change nephropathy, membranous nephropathy, lupus nephritis, interstitial nephritis, etc.
Because the hormone has an immunosuppressive effect, it will reduce the immunity of the body, and it is easy to cause a variety of side effects such as full moon face, central obesity, etc., but as long as you follow the doctor’s advice and use the amount, the side effects will not damage The body, and most of them will recover after stopping the drug. In general, the advantages outweigh the disadvantages.
“New Star” in the protein drug industry——Angiotensin-Converting Enzyme Inhibitor (ACEI)
Do nephropathy patients with hypertension feel familiar? The name, yes, the “official job” of this drug is to lower blood pressure, and the part-time job is to “lower protein and delay kidney function”. Impaired renal function can lead to renal hypertension, which in turn can lead to increased intraglomerular pressure and aggravate renal damage. ACEI drugs can inhibit the increase in renal intravascular pressure and reduce renal damage while lowering blood pressure. Thereby play a role in protecting kidney function and reduce the leakage of protein.
ACEI drugs are also known as Puli drugs, such as captopril, enalapril and benazepril commonly used by kidney friends.
——angiotensin II receptor blocker (ARB)
ARB and ACEI are both antihypertensive drugs. It also has the effect of reducing protein and delaying the progress of renal function. Mainly by blocking angiotensin 1, thereby blocking angiotensin II, reducing blood pressure while improving the permeability of the glomerular filtration membrane, reducing the leakage of proteins, and reducing the extracellular matrix in the glomerulus. accumulation to delay the progression of glomerulosclerosis.
Some side effects of these two types of drugs are also criticized by many kidney friends, mainly the side effects of increasing creatinine and blood potassium. In fact, as long as these two indicators are controlled within the normal range, there is no need to stop the drug , but pay attention to monitoring these two indicators. In addition, these two types of drugs cannot be taken at the same time.
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